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How to get fromSt. Louis to Mobileby plane, car, bus, or train

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There are 9 ways to get from St. Louis to Mobile by plane, car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Lambert–St. Louis International Airport to Destin–Fort Walton Beach Airport, drive

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Destin–Fort Walton Beach Airport (VPS)plane plane STL - VPS
    2. Drive from Destin–Fort Walton Beach Airport (VPS) to Mobilecar car
    5h 28m
    $116–580

  2. Fly Lambert–St. Louis International Airport to Pensacola International Airport, bus

    cheapest
    1. Fly from Lambert–St. Louis International Airport (STL) to Pensacola International Airport (PNS)plane plane STL - PNS
    2. Take the bus from Pensacola Airport to Mobile Bus Stationbus bus
    7h 3m
    $106–520

  3. Bus, train

    1. Take the bus from St Louis Bus Station to New Orleans Bus Stationbus bus Greyhound US1173
    2. Take the train from New Orleans Union Passenger Terminal to Mobile Amtrak Statrain train Amtrak Mardi Gras Service / ...
    20h 33m
    $135–290

  4. Bus, train via Carbondale

    1. Take the bus from St. Louis to Carbondalebus bus
    2. Take the train from Carbondale to New Orleans Union Passenger Terminaltrain train
    3. Take the train from New Orleans Union Passenger Terminal to Mobile Amtrak Statrain train
    20h 36m
    $233–542

  5. Drive 642.5 mi

    1. Drive from St. Louis to Mobilecar car 642.5 mi
    11h 47m
    $118–170

  6. Fly Midamerica St. Louis Airport to Destin–Fort Walton Beach Airport, drive

    1. Fly from Midamerica St. Louis Airport (BLV) to Destin–Fort Walton Beach Airport (VPS)plane plane BLV - VPS
    2. Drive from Destin–Fort Walton Beach Airport (VPS) to Mobilecar car
    5h 49m
    $110–418

  7. Fly Lambert–St. Louis International Airport to Mobile Regional Airport

    1. Fly from Lambert–St. Louis International Airport (STL) to Mobile Regional Airport (MOB)plane plane STL - MOB
    9h 20m
    $112–602

  8. Fly Lambert–St. Louis International Airport to Northwest Florida Beaches International Airport, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Northwest Florida Beaches International Airport (ECP)plane plane STL - ECP
    2. Drive from Northwest Florida Beaches International Airport (ECP) to Mobilecar car
    6h 33m
    $130–598

  9. Fly Lambert–St. Louis International Airport to Louis Armstrong New Orleans International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Louis Armstrong New Orleans International Airport (MSY)plane plane STL - MSY
    2. Take the train from New Orleans Union Passenger Terminal to Mobile Amtrak Statrain train
    8h 24m
    $136–652

St. Louis to Mobile by bus and train

Calendar7Weekly Services
Duration20h 33mAverage Duration
Ticket$135Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Mobile.ExpandLaunch map view
  • Distance: 729.2 mi
  • Duration: 5h 28m

What companies run services between St. Louis, MO, USA and Mobile, AL, USA?

Delta, United Airlines, and American Airlines fly from Lambert–St. Louis International Airport (STL) to Mobile Regional Airport (MOB) every 2 hours.

Airlines
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Bus operators

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