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There are 6 ways to get from St. Louis to Louisville by bus, night bus, car or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Bus via Nashville, Tn  •  10h 40m

  1. Take the bus from St Louis, Mo to Nashville, Tn 1163 / ...
  2. Take the bus from Nashville, Tn to Louisville, Ky 1196 / ...

$57 - $140

Cheapest option

Night bus, bus  •  10h 5m

  1. Take the night bus from St Louis, Mo to Nashville, Tn 4711
  2. Take the bus from Nashville, Tn to Louisville, Ky 1196 / ...

$57 - $137

4 alternative options

Bus  •  11h 13m

  1. Take the bus from St Louis, Mo to Terre Haute, In
  2. Take the bus from Terre Haute, IN to Bloomington, IN
  3. Take the bus from Bloomington, IN to Louisville, KY

$64 - $112

Drive  •  4h 17m

  1. Drive from St. Louis to Louisville 260.8 miles

$25 - $40

Fly to Louisville  •  5h 56m

  1. Fly from St. Louis (STL) to Louisville (SDF) STL - SDF

$184 - $906

Fly to Owensboro, bus  •  5h 56m

  1. Fly from St. Louis (STL) to Owensboro (OWB) STL - OWB
  2. Take the bus from Owensboro, KY to Louisville, KY

$68 - $112

Questions & Answers

The cheapest way to get from St. Louis to Louisville is to drive which costs $25 - $40 and takes 4h 17m.

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The quickest way to get from St. Louis to Louisville is to drive which costs $25 - $40 and takes 4h 17m.

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No, there is no direct bus from St. Louis to Louisville. However, there are services departing from St Louis, Mo and arriving at Louisville, Ky via Nashville, Tn. The journey, including transfers, takes approximately 10h 40m.

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The distance between St. Louis and Louisville is 243 miles. The road distance is 260.8 miles.

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The best way to get from St. Louis to Louisville without a car is to bus which takes 10h 40m and costs $55 - $140.

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It takes approximately 10h 40m to get from St. Louis to Louisville, including transfers.

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St. Louis to Louisville bus services, operated by Greyhound USA, depart from St Louis, Mo station.

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The best way to get from St. Louis to Louisville is to bus which takes 10h 40m and costs $55 - $140. Alternatively, you can fly, which costs $180 - $950 and takes 5h 56m.

Mode details

There is no direct flight from St. Louis Airport to Louisville Airport. The quickest flight takes 3h 20m and has one stopover.

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St. Louis to Louisville bus services, operated by Greyhound USA, arrive at Louisville, Ky station.

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Map of how to get from St. Louis to Louisville.
Launch map view
  • Distance: 243 miles
  • Duration: 10h 40m

What companies run services between St. Louis, MO, USA and Louisville, KY, USA?

You can take a bus from St. Louis to Louisville via Nashville, Tn in around 10h 40m. Alternatively, Southwest Airlines, Delta and two other airlines fly from St. Louis to Louisville hourly.

Airlines
American Airlines
Website
aa.com
Flights from St. Louis to Louisville via Chicago O'Hare
Ave. Duration
4h 4m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$180 - $900
Flights from St. Louis to Louisville via Charlotte
Ave. Duration
4h 38m
When
Every day
Estimated price
$210 - $950
Flights from St. Louis to Louisville via Dallas/Ft.Worth
Ave. Duration
5h 2m
When
Every day
Estimated price
$240 - $1,000
Flights from St. Louis to Owensboro
Ave. Duration
1h 9m
When
Every day
Estimated price
$24 - $110
Delta
Website
delta.com
Flights from St. Louis to Louisville via Atlanta
Ave. Duration
4h 17m
When
Every day
Estimated price
$180 - $950
Flights from St. Louis to Louisville via Detroit
Ave. Duration
4h 9m
When
Saturday
Estimated price
$180 - $900
Flights from St. Louis to Louisville via Minneapolis
Ave. Duration
5h 7m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$200 - $1,000
Southwest Airlines
Website
southwest.com
Flights from St. Louis to Louisville via Chicago Midway
Ave. Duration
3h 41m
When
Every day
Estimated price
$190 - $850
Flights from St. Louis to Louisville via Tampa
Ave. Duration
5h 15m
When
Monday to Friday
Estimated price
$300 - $1,100
United Airlines
Website
united.com
Flights from St. Louis to Louisville via Chicago O'Hare
Ave. Duration
4h
When
Every day
Estimated price
$190 - $950
Flights from St. Louis to Louisville via Washington Dulles
Ave. Duration
5h 2m
When
Every day
Estimated price
$230 - $1,100
Cape Air
Website
capeair.com
Flights from St. Louis to Owensboro
Ave. Duration
1h 9m
When
Every day
Estimated price
$24 - $110
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from St Louis, Mo to Nashville, Tn
Ave. Duration
5h 40m
Frequency
4 times a day
Estimated price
$35 - $85
Website
greyhound.com
Economy
$35 - $55
Flexible
$65 - $85
Bus from Nashville, Tn to Louisville, Ky
Ave. Duration
4h
Frequency
Every 3 hours
Estimated price
$22 - $55
Website
greyhound.com
Economy
$22 - $35
Flexible
$40 - $55
Bus from St Louis, Mo to Terre Haute, In
Ave. Duration
4h 15m
Frequency
Once daily
Estimated price
$22 - $55
Website
greyhound.com
Economy
$22 - $35
Flexible
$40 - $55
Hoosier Ride
Phone
800-544-2383
Website
hoosierride.com
Bus from Terre Haute, IN to Bloomington, IN
Ave. Duration
1h 35m
Frequency
Once daily
Estimated price
$16 - $24
Book at
hoosierride.com
Bus from Bloomington, IN to Louisville, KY
Ave. Duration
2h 20m
Frequency
Once daily
Estimated price
$24 - $35
Book at
hoosierride.com
Bus from Owensboro, KY to Louisville, KY
Ave. Duration
2h 10m
Frequency
Twice daily
Estimated price
$27 - $35
Book at
hoosierride.com

Want to know more about travelling around United States

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More Questions & Answers

Louisville is 1h ahead of St. Louis. It is currently 11:15 PM in St. Louis and 12:15 AM in Louisville.

Yes, the driving distance between St. Louis to Louisville is 261 miles. It takes approximately 4h 17m to drive from St. Louis to Louisville.

Get driving directions

United Airlines, Southwest Airlines, Delta and American Airlines offer flights from St. Louis Airport to Louisville Airport.

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Book your St. Louis to Louisville bus tickets online with Greyhound and Greyhound.

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There are 191+ hotels available in Louisville. Prices start at $64 USD per night.

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The best way to get from St. Louis to St. Louis Airport is to train which takes 31m and costs $3.

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