There are 6 ways to get from St. Louis to Louisville by bus, night bus, car or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Bus  •  9 h 58 min

  1. Take the bus from St Louis, Mo to Champaign, Il
  2. Take the bus from Champaign, IL to Indianapolis, IN
  3. Take the bus from Indianapolis, IN to Louisville, KY

$65 - $127

Cheapest option

Night bus, bus  •  9 h 18 min

  1. Take the night bus from St Louis, Mo to Nashville, Tn 4711
  2. Take the bus from Nashville, Tn to Louisville, Ky 1196 / ...

$57 - $137

4 alternative options

Bus via Terre Haute, In  •  10 h 24 min

  1. Take the bus from St Louis, Mo to Terre Haute, In
  2. Take the bus from Terre Haute, IN to Bloomington, IN
  3. Take the bus from Bloomington, IN to Louisville, KY

$60 - $110

Drive  •  4 h 17 min

  1. Drive from St. Louis to Louisville 260.8 miles

$25 - $40

Fly to Louisville  •  5 h 50 min

  1. Fly from St. Louis (STL) to Louisville (SDF) STL - SDF

$183 - $905

Fly to Owensboro, bus  •  5 h 55 min

  1. Fly from St. Louis (STL) to Owensboro (OWB) STL - OWB
  2. Take the bus from Owensboro, KY to Louisville, KY

$68 - $111

Questions & Answers

The cheapest way to get from St. Louis to Louisville is to drive which costs $25 - $40 and takes 4 h 17 min.

More details

The quickest way to get from St. Louis to Louisville is to drive which takes 4 h 17 min and costs $25 - $40.

More details

The distance between St. Louis and Louisville is 389 km. The road distance is 417 km.

Get driving directions

It takes approximately 9 h 58 min to get from St. Louis to Louisville, including transfers.

More details

No, there is no direct bus from St. Louis to Louisville. However, there are services departing from St Louis, Mo and arriving at Louisville, KY via Champaign, IL and Indianapolis, IN. The journey, including transfers, takes approximately 9 h 58 min.

More details

What companies run services between St. Louis, MO, USA and Louisville, KY, USA?

You can take a bus from St. Louis to Louisville via Champaign, Il, Champaign, IL, Indianapolis, IN, and Indianapolis, IN in around 9 h 58 min. Alternatively, Southwest Airlines, Delta and two other airlines fly from St. Louis to Louisville hourly.

Airlines
American Airlines
Website
aa.com
Flights from St. Louis to Louisville via Chicago O'Hare
Ave. Duration
4 h 16 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$180 - $900
Flights from St. Louis to Louisville via Charlotte
Ave. Duration
4 h 30 min
When
Every day
Estimated price
$210 - $950
Flights from St. Louis to Louisville via Dallas/Ft.Worth
Ave. Duration
4 h 53 min
When
Every day
Estimated price
$240 - $1,000
Flights from St. Louis to Louisville via Reagan Washington
Ave. Duration
4 h 53 min
When
Monday to Friday
Estimated price
$230 - $1,000
Flights from St. Louis to Owensboro
Ave. Duration
1 h 9 min
When
Every day
Estimated price
$24 - $110
Delta
Website
delta.com
Flights from St. Louis to Louisville via Detroit
Ave. Duration
4 h
When
Every day
Estimated price
$180 - $900
Flights from St. Louis to Louisville via Atlanta
Ave. Duration
4 h 14 min
When
Every day
Estimated price
$180 - $950
Southwest Airlines
Website
southwest.com
Flights from St. Louis to Louisville via Chicago Midway
Ave. Duration
3 h 40 min
When
Monday to Saturday
Estimated price
$190 - $850
Flights from St. Louis to Louisville via Baltimore
Ave. Duration
4 h 35 min
When
Monday to Saturday
Estimated price
$260 - $1,000
Cape Air
Website
capeair.com
Flights from St. Louis to Owensboro
Ave. Duration
1 h 9 min
When
Every day
Estimated price
$24 - $110
United Airlines
Website
united.com
Flights from St. Louis to Louisville via Chicago O'Hare
Ave. Duration
3 h 58 min
When
Every day
Estimated price
$190 - $950
Bus operators
Greyhound USA
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from St Louis, Mo to Champaign, Il
Ave. Duration
3 h
Frequency
Hourly
Estimated price
$23 - $55
Website
greyhound.com
Economy
$23 - $35
Flexible
$40 - $55
Bus from St Louis, Mo to Terre Haute, In
Ave. Duration
4 h 15 min
Frequency
Every 4 hours
Estimated price
$22 - $55
Website
greyhound.com
Economy
$22 - $35
Flexible
$40 - $55
Night bus from St Louis, Mo to Nashville, Tn
Ave. Duration
5 h 5 min
Frequency
Hourly
Estimated price
$30 - $85
Website
greyhound.com
Economy
$30 - $55
Flexible
$60 - $85
Bus from Nashville, Tn to Louisville, Ky
Ave. Duration
4 h
Frequency
Every 30 minutes
Estimated price
$22 - $55
Website
greyhound.com
Economy
$22 - $35
Flexible
$40 - $55
Burlington Trailways
Hoosier Ride
Phone
800-544-2383
Website
hoosierride.com
Bus from Terre Haute, IN to Bloomington, IN
Ave. Duration
1 h 35 min
Frequency
Once daily
Estimated price
$14 - $24
Schedules at
hoosierride.com
Book at
hos.tdstickets.com
Bus from Bloomington, IN to Louisville, KY
Ave. Duration
2 h 25 min
Frequency
Once daily
Estimated price
$24 - $35
Schedules at
hoosierride.com
Book at
hos.tdstickets.com
Bus from Owensboro, KY to Louisville, KY
Ave. Duration
2 h 10 min
Frequency
Once daily
Estimated price
$27 - $35
Schedules at
hoosierride.com
Book at
hos.tdstickets.com

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