There are 5 ways to get from St. Louis to Louisville by bus, car or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Bus via Nashville, Tn  •  9 h 53 min

  1. Take the bus from St Louis, Mo to Nashville, Tn 1163 / ...
  2. Take the bus from Nashville, Tn to Louisville, Ky 1196 / ...

$57 - $140

4 alternative options

Bus  •  10 h 21 min

  1. Take the bus from St Louis, Mo to Terre Haute, In
  2. Take the bus from Terre Haute, IN to Bloomington, IN
  3. Take the bus from Bloomington, IN to Louisville, KY

$64 - $112

Drive  •  4 h 17 min

  1. Drive from St. Louis to Louisville 260.8 miles

$25 - $40

Fly to Louisville  •  6 h 1 min

  1. Fly from St. Louis (STL) to Louisville (SDF) STL - SDF

$184 - $906

Fly to Owensboro, bus  •  5 h 56 min

  1. Fly from St. Louis (STL) to Owensboro (OWB) STL - OWB
  2. Take the bus from Owensboro, KY to Louisville, KY

$68 - $112

Questions & Answers

The cheapest way to get from St. Louis to Louisville is to drive which costs $25 - $40 and takes 4 h 17 min.

More details

The quickest way to get from St. Louis to Louisville is to drive which costs $25 - $40 and takes 4 h 17 min.

More details

No, there is no direct bus from St. Louis to Louisville. However, there are services departing from St Louis, Mo and arriving at Louisville, Ky via Nashville, Tn. The journey, including transfers, takes approximately 9 h 53 min.

More details

The distance between St. Louis and Louisville is 243 miles. The road distance is 260.8 miles.

Get driving directions

The best way to get from St. Louis to Louisville without a car is to bus which takes 9 h 53 min and costs $55 - $140.

More details

It takes approximately 9 h 53 min to get from St. Louis to Louisville, including transfers.

More details

St. Louis to Louisville bus services, operated by Greyhound USA, depart from St Louis, Mo station.

More details

The best way to get from St. Louis to Louisville is to bus which takes 9 h 53 min and costs $55 - $140. Alternatively, you can fly, which costs $180 - $950 and takes 6 h 1 min.

Mode details

There is no direct flight from St. Louis Airport to Louisville Airport. The quickest flight takes 3 h 25 min and has one stopover.

Search flights

St. Louis to Louisville bus services, operated by Greyhound USA, arrive at Louisville, Ky station.

More details

Map of how to get from St. Louis to Louisville.
Launch map view
  • Distance: 243 miles
  • Duration: 9 h 53 min

What companies run services between St. Louis, MO, USA and Louisville, KY, USA?

You can take a bus from St. Louis to Louisville via Nashville, Tn in around 9 h 53 min. Alternatively, Southwest Airlines, United Airlines and two other airlines fly from St. Louis to Louisville hourly.

Airlines
American Airlines
Website
aa.com
Flights from St. Louis to Louisville via Chicago O'Hare
Ave. Duration
4 h 15 min
When
Every day
Estimated price
$180 - $900
Flights from St. Louis to Louisville via Charlotte
Ave. Duration
4 h 44 min
When
Every day
Estimated price
$210 - $950
Flights from St. Louis to Louisville via Dallas/Ft.Worth
Ave. Duration
4 h 59 min
When
Monday to Saturday
Estimated price
$240 - $1,000
Flights from St. Louis to Owensboro
Ave. Duration
1 h 9 min
When
Every day
Estimated price
$24 - $110
Delta
Website
delta.com
Flights from St. Louis to Louisville via Atlanta
Ave. Duration
4 h 10 min
When
Every day
Estimated price
$180 - $950
Flights from St. Louis to Louisville via Detroit
Ave. Duration
4 h 11 min
When
Every day
Estimated price
$180 - $900
Flights from St. Louis to Louisville via Minneapolis
Ave. Duration
5 h 1 min
When
Every day
Estimated price
$200 - $1,000
Southwest Airlines
Website
southwest.com
Flights from St. Louis to Louisville via Chicago Midway
Ave. Duration
4 h 3 min
When
Every day
Estimated price
$190 - $850
United Airlines
Website
united.com
Flights from St. Louis to Louisville via Chicago O'Hare
Ave. Duration
3 h 52 min
When
Every day
Estimated price
$190 - $950
Flights from St. Louis to Louisville via Washington Dulles
Ave. Duration
5 h 5 min
When
Every day
Estimated price
$230 - $1,100
Cape Air
Website
capeair.com
Flights from St. Louis to Owensboro
Ave. Duration
1 h 9 min
When
Every day
Estimated price
$24 - $110
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from St Louis, Mo to Nashville, Tn
Ave. Duration
5 h 40 min
Frequency
Hourly
Estimated price
$35 - $85
Website
greyhound.com
Economy
$35 - $55
Flexible
$65 - $85
Bus from Nashville, Tn to Louisville, Ky
Ave. Duration
4 h
Frequency
Every 30 minutes
Estimated price
$22 - $55
Website
greyhound.com
Economy
$22 - $35
Flexible
$40 - $55
Bus from St Louis, Mo to Terre Haute, In
Ave. Duration
4 h 15 min
Frequency
Every 4 hours
Estimated price
$22 - $55
Website
greyhound.com
Economy
$22 - $35
Flexible
$40 - $55
Hoosier Ride
Phone
800-544-2383
Website
hoosierride.com
Bus from Terre Haute, IN to Bloomington, IN
Ave. Duration
1 h 35 min
Frequency
Once daily
Estimated price
$16 - $24
Book at
hoosierride.com
Bus from Bloomington, IN to Louisville, KY
Ave. Duration
2 h 20 min
Frequency
Once daily
Estimated price
$24 - $35
Book at
hoosierride.com
Bus from Owensboro, KY to Louisville, KY
Ave. Duration
2 h 10 min
Frequency
Twice daily
Estimated price
$27 - $35
Book at
hoosierride.com

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

More Questions & Answers

Louisville is 1 h ahead of St. Louis. It is currently 7:30 PM in St. Louis and 8:30 PM in Louisville.

Yes, the driving distance between St. Louis to Louisville is 261 miles. It takes approximately 4 h 17 min to drive from St. Louis to Louisville.

Get driving directions

United Airlines, Southwest Airlines, American Airlines and Delta offer flights from St. Louis Airport to Louisville Airport.

Search flights

Book your St. Louis to Louisville bus tickets online with Greyhound and Greyhound.

Search and book

There are 191+ hotels available in Louisville. Prices start at $66 USD per night.

More details

The best way to get from St. Louis to St. Louis Airport is to train which takes 31 min and costs $3.

More details