Southwest Airlines flies from St. Louis to Little Rock twice daily. Alternatively, Amtrak operates a train from St. Louis to Little Rock once daily. Tickets cost $55 - $150 and the journey takes 7 h 7 min.
From CIVIC CENTER station train to St. Louis airport, fly to Little Rock airport, then line 20 bus to Little Rock. 3 h 48 min $606. From St. Louis Gateway Station Amtrak train to Little Rock Union Station Amtrak. 7 h 7 min $108. From St. Louis, MO bus to Little Rock, AR. 9 h 45 min $47. From St. Louis drive to Little Rock. 6 h 33 min $48.