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How to get fromSt. Louis to Lexingtonby bus (Greyhound), car or plane

Find Transport to Lexington

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There are 4 ways to get from St. Louis to Lexington by bus (Greyhound), car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus (Greyhound)

    best
    1. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus Greyhound US0421
    2. Take the bus from Indianapolis Union Station to Lexington Bus Stopbus bus Greyhound US0120
    9h 27m
    $101–170

  2. Drive 337.8 mi

    cheapest
    1. Drive from St. Louis to Lexingtoncar car 337.8 mi
    5h 44m
    $62–90

  3. Fly to Louisville International Airport, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Louisville International Airport (SDF)plane plane STL - SDF
    2. Drive from Louisville-Airport-SDF to Lexingtoncar car
    6h 15m
    $126–724

  4. Fly to Blue Grass Airport

    1. Fly from Lambert–St. Louis International Airport (STL) to Blue Grass Airport (LEX)plane plane STL - LEX
    7h 45m
    $100–554

Lambert–St. Louis International Airport (STL) to Louisville International Airport (SDF) flights

Calendar85Weekly Planes
Duration4h 39mAverage Duration
Ticket$115Cheapest Price
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Questions & Answers

What companies run services between St. Louis, MO, USA and Lexington, KY, USA?

You can take a bus from St Louis Bus Station to Lexington via Indianapolis Union Station and Lexington Bus Stop in around 9h 27m. Alternatively, American Airlines, Delta, and United Airlines fly from Lambert–St. Louis International Airport (STL) to Blue Grass Airport (LEX) every 2 hours.

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Need to know: Greyhound

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