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How to get fromSt. Louis to Lexingtonby bus (Greyhound), car, plane or bus (Flixbus, Greyhound)

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There are 5 ways to get from St. Louis to Lexington by bus (Greyhound), car, plane, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus (Greyhound)

    best
    1. Take the bus from St Louis Bus Station to Indianapolis Union StationbusGreyhound US0421
    2. Take the bus from Indianapolis Union Station to Lexington Bus StopbusGreyhound US0120
    9h 27m
    $93–196

  2. Drive 337.8 mi

    cheapest
    1. Drive from St. Louis to Lexingtoncar337.8 mi
    5h 40m
    $62–90

  3. Fly to Louisville International Airport, drive

    1. Fly from Lambert–St. Louis International Airport (STL) to Louisville International Airport (SDF)planeSTL - SDF
    2. Drive from Louisville-Airport-SDF to Lexingtoncar
    6h
    $126–724

  4. Bus via Champaign

    1. Take the bus from St Louis Bus Station to Champaign Intermodal Trans Ctrbus
    2. Take the bus from Champaign to Indianapolis Union Stationbus
    3. Take the bus from Indianapolis Union Station to Lexington Bus Stopbus
    12h 27m
    $111–237

  5. Fly to Blue Grass Airport

    1. Fly from Lambert–St. Louis International Airport (STL) to Blue Grass Airport (LEX)planeSTL - LEX
    7h 46m
    $214–1,204

Lambert–St. Louis International Airport (STL) to Louisville International Airport (SDF) flights

Calendar126Weekly Planes
Duration4h 48mAverage Duration
Ticket$117Cheapest Price
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Questions & Answers

What companies run services between St. Louis, MO, USA and Lexington, KY, USA?

You can take a bus from St Louis Bus Station to Lexington via Indianapolis Union Station and Lexington Bus Stop in around 9h 27m. Alternatively, Delta, United Airlines, and American Airlines fly from Lambert–St. Louis International Airport (STL) to Blue Grass Airport (LEX) hourly.

Airlines
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Want to know more about travelling around United States

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Need to know: Greyhound

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