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How to get fromSt. Louis to Key Westby plane, bus (Greyhound, Flixbus), or car

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There are 5 ways to get from St. Louis to Key West by plane, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Lambert–St. Louis International Airport

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Key West International Airport (EYW)plane plane STL - EYW
    6h 2m
    $124–566

  2. Fly from Midamerica St. Louis Airport

    cheapest
    1. Fly from Midamerica St. Louis Airport (BLV) to Key West International Airport (EYW)plane plane BLV - EYW
    14h 14m
    $116–424

  3. Bus

    1. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    4. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    32h 31m
    $209–418

  4. Drive 1,350.2 mi

    1. Drive from St. Louis to Key Westcar car 1,350.2 mi
    23h 43m
    $247–356

  5. Bus via Evansville

    1. Take the bus from St Louis Bus Station to Evansville Bus Stationbus bus
    2. Take the bus from Evansville Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Miami Airport Stationbus bus
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    5. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    34h 26m
    $208–424

St. Louis to Key West by bus and foot

Calendar19Weekly Services
Duration32h 31mAverage Duration
Ticket$209Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Key West.ExpandLaunch map view
  • Distance: 1,118 mi
  • Duration: 6h 2m

What companies run services between St. Louis, MO, USA and Key West, FL, USA?

Delta, American Airlines, and United Airlines fly from Lambert–St. Louis International Airport (STL) to Key West International Airport (EYW) every 4 hours. Alternatively, you can take a bus from St Louis Bus Station to N Roosevelt & 3rd Street via Atlanta Bus Station, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 32h 31m.

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