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How to get fromSt. Louis to Key Westby plane, bus (Flixbus, Greyhound), car, bus, or bus (Greyhound, Flixbus)

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There are 6 ways to get from St. Louis to Key West by plane, bus (Flixbus, Greyhound), car, bus, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Lambert–St. Louis International Airport

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Key West International Airport (EYW)plane plane STL - EYW
    6h 41m
    $124–566

  2. Fly from Midamerica St. Louis Airport

    cheapest
    1. Fly from Midamerica St. Louis Airport (BLV) to Key West International Airport (EYW)plane plane BLV - EYW
    6h 58m
    $112–414

  3. Bus

    1. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    4. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    31h 26m
    $177–405

  4. Drive 1,350.3 mi

    1. Drive from St. Louis to Key Westcar car 1,350.3 mi
    23h 43m
    $247–356

  5. Bus to Evansville, fly

    1. Take the bus from St Louis Bus Station to Evansville Bus Stationbus bus
    2. Fly from Evansville (EVV) to Key West International Airport (EYW)plane plane EVV - EYW
    8h 56m
    $127–436

  6. Bus via Evansville

    1. Take the bus from St Louis Bus Station to Evansville Bus Stationbus bus
    2. Take the bus from Evansville Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Miami Airport Stationbus bus
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    5. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    34h 1m
    $185–412

St. Louis to Key West by bus and foot

Calendar14Weekly Services
Duration31h 26mAverage Duration
Ticket$177Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Key West.ExpandLaunch map view
  • Distance: 1,118 mi
  • Duration: 6h 41m

What companies run services between St. Louis, MO, USA and Key West, FL, USA?

American Airlines, Delta, and United Airlines fly from Lambert–St. Louis International Airport (STL) to Key West International Airport (EYW) every 3 hours. Alternatively, you can take a bus from St Louis Bus Station to N Roosevelt & 3rd Street via Atlanta Bus Station, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 31h 26m.

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