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How to get fromSt. Louis to Ithacaby plane, train, bus, bus (Greyhound) or car

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There are 8 ways to get from St. Louis to Ithaca by plane, train, bus, bus (Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Ithaca Tompkins Regional Airport

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Ithaca Tompkins Regional Airport (ITH)plane plane STL - ITH
    8h 28m
    $112–602

  2. Train, bus

    1. Take the train from St. Louis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Syracuse Regional Transportation Centertrain train
    3. Take the bus from Syracuse Bus Station to Ithacabus bus
    21h 2m
    $280–611

  3. Bus

    1. Take the bus from St Louis Bus Station to Harrisburg Bus Stationbus bus
    2. Take the bus from Harrisburg, Pa to Scranton, Pabus bus 770
    3. Take the bus from Scranton, Pa to Ithacabus bus 246
    27h 5m
    $191–409

  4. Drive 862.3 mi

    1. Drive from St. Louis to Ithacacar car 862.3 mi
    15h 16m
    $158–228

  5. Fly to Rochester, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Rochester (ROC)plane plane STL - ROC
    2. Take the bus from Rochester to Ithacabus bus
    8h 25m
    $192–932

  6. Fly to Greater Binghamton Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Greater Binghamton Airport (BGM)plane plane STL - BGM
    2. Take the bus from Binghamton to Ithacabus bus
    9h 54m
    $144–660

  7. Fly to Elmira/Corning Regional Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Elmira/Corning Regional Airport (ELM)plane plane STL - ELM
    2. Take the bus from Transit Center - PO Side to Tompkins County Librarybus bus
    8h 46m

  8. Fly to Syracuse Hancock International Airport, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Syracuse Hancock International Airport (SYR)plane plane STL - SYR
    2. Take the bus from Syracuse Bus Station to Ithacabus bus
    9h 1m
    $214–1,144

St. Louis to Ithaca by train and bus

Calendar5Weekly Services
Duration21h 2mAverage Duration
Ticket$280Cheapest Price
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Questions & Answers

What companies run services between St. Louis, MO, USA and Ithaca, NY, USA?

United Airlines and Delta fly from Lambert–St. Louis International Airport (STL) to Ithaca Tompkins Regional Airport (ITH) 4 times a day. Alternatively, you can take a bus from St Louis Bus Station to Ithaca via Harrisburg, Pa and Scranton, Pa in around 27h 5m.

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