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How to get fromSt. Louis to Itascaby train (Amtrak), bus (Flixbus), car, plane, train or bus

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There are 8 ways to get from St. Louis to Itasca by train (Amtrak), bus (Flixbus), car, plane, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from St. Louis to Chicago Union Stationtrain train Lincoln Service / ...
    6h 15m
    $41–132

  2. Bus (Flixbus)

    1. Take the bus from St Louis Bus Station to Chicago Bus Stationbus bus FlixBus N2521 / ...
    7h 44m
    $41–69

  3. Drive 288.4 mi

    1. Drive from St. Louis to Itascacar car 288.4 mi
    4h 58m
    $53–76

  4. Fly Lambert–St. Louis International Airport to Chicago Midway International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Chicago Midway International Airport (MDW)plane plane STL - MDW
    2. Take the train from Chicago Union Station to Itascatrain train
    4h 49m
    $78–564

  5. Fly Lambert–St. Louis International Airport to Chicago O'Hare International Airport, line 331 bus, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Chicago O'Hare International Airport (ORD)plane plane STL - ORD
    2. Take the bus from Cumberland CTA Station to Thatcher/Arnold/Metra Stationbus bus
    3. Take the train from River Grove to Itascatrain train
    4h 47m
    $238–506

  6. Drive to Decatur Airport, fly to Chicago O'Hare International Airport

    1. Drive from St. Louis to Decatur Airport (DEC)car car
    2. Fly from Decatur Airport (DEC) to Chicago O'Hare International Airport (ORD)plane plane DEC - ORD
    5h 40m
    $58–265

  7. Train to Abraham Lincoln Capital Airport, fly to Chicago O'Hare International Airport

    1. Take the train from St. Louis to Springfieldtrain train
    2. Fly from Abraham Lincoln Capital Airport (SPI) to Chicago O'Hare International Airport (ORD)plane plane SPI - ORD
    5h 56m
    $67–307

  8. Bus to Williamson County Regional Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from St. Louis to Carbondalebus bus
    2. Fly from Williamson County Regional Airport (MWA) to Chicago O'Hare International Airport (ORD)plane plane MWA - ORD
    6h 45m
    $117–254

St. Louis to Itasca by train (Amtrak)

Calendar38Weekly Trains
Duration6h 15mAverage Duration
Ticket$41Cheapest Price
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Questions & Answers

What companies run services between St. Louis, MO, USA and Itasca, IL, USA?

Amtrak operates a train from St. Louis to Chicago Union Station 5 times a day. Tickets cost $35–130 and the journey takes 4h 55m. Alternatively, Flixbus USA operates a bus from St Louis Bus Station to Chicago Bus Station 3 times a day. Tickets cost $35–65 and the journey takes 6h 15m.

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