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How to get fromSt. Louis to Irvineby plane, bus, train, train (Amtrak) or car

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There are 8 ways to get from St. Louis to Irvine by plane, bus, train, train (Amtrak), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to John Wayne Airport Orange County

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to John Wayne Airport Orange County (SNA)plane plane STL - SNA
    7h 21m
    $232–1,102

  2. Bus, train

    cheapest
    1. Take the bus from St Louis Bus Station to Los Angeles Union Stationbus bus Greyhound US1210
    2. Take the train from L.A. Union Station to Tustintrain train OC Line
    40h 46m
    $139–514

  3. Train (Amtrak)

    1. Take the train from St. Louis to Kansas Citytrain train Missouri River Runner / ...
    2. Take the train from Kansas City to Fullerton Amtrak Stationtrain train Southwest Chief
    42h 55m
    $181–1,621

  4. Drive 1,807.2 mi

    1. Drive from St. Louis to Irvinecar car 1,807.2 mi
    28h 48m
    $330–477

  5. Fly to Los Angeles International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Los Angeles International Airport (LAX)plane plane STL - LAX
    2. Take the train from L.A. Union Station to Tustintrain train
    9h 6m
    $232–778

  6. Fly to Burbank Bob Hope Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Burbank Bob Hope Airport (BUR)plane plane STL - BUR
    2. Take the train from L.A. Union Station to Tustintrain train
    9h 29m
    $376–820

  7. Fly to San Diego International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to San Diego International Airport (SAN)plane plane STL - SAN
    2. Take the train from San Diego Old Town Transportation Center to Irvinetrain train
    9h 37m
    $300–1,336

  8. Train, bus

    1. Take the train from St. Louis to Pomona Amtraktrain train Texas Eagle
    2. Take the bus from Ring-Brea Mall to Campus-University Centerbus bus 59
    2d 14h
    $203–642

St. Louis to Irvine by bus and train

Calendar12Weekly Services
Duration40h 46mAverage Duration
Ticket$139Cheapest Price
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Questions & Answers

What companies run services between St. Louis, MO, USA and Irvine, CA, USA?

Southwest Airlines, American Airlines, and two other airlines fly from Lambert–St. Louis International Airport (STL) to John Wayne Airport Orange County (SNA) hourly. Alternatively, you can take a train from St. Louis to Tustin via Kansas City, Fullerton Amtrak Station, and Fullerton in around 42h 55m.

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