There are 4 ways to get from St. Louis to Indianapolis by bus (Greyhound), train (Amtrak), car, or plane
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus (Greyhound)
best- Take the bus from St Louis Bus Station to Indianapolis Union Stationbus Greyhound US0421
4h 25m$30–65Train (Amtrak)
- Take the train from St. Louis to Chicago Union Stationtrain Lincoln Service / ...
- Take the train from Chicago Union Station to Indianapolistrain Cardinal
10h 49m$71–210Drive 241.2 mi
- Drive from St. Louis to Indianapoliscar 241.2 mi
4h 3m$44–64Fly
- Fly from Lambert–St. Louis International Airport (STL) to Indianapolis (IND)plane STL - IND
5h 47m$294–554
St. Louis to Indianapolis by bus (Greyhound)
Questions & Answers
The cheapest way to get from St. Louis to Indianapolis is to bus which costs $30 - $65 and takes 4h 25m.
The fastest way to get from St. Louis to Indianapolis is to drive which takes 4h 3m and costs $40 - $65.
Yes, there is a direct bus departing from St Louis Bus Station station and arriving at Indianapolis Union Station station. Services depart three times a day, and operate every day. The journey takes approximately 4h 25m.
No, there is no direct train from St. Louis to Indianapolis. However, there are services departing from St. Louis and arriving at Indianapolis via Chicago Union Station. The journey, including transfers, takes approximately 10h 49m.
The distance between St. Louis and Indianapolis is 243 miles. The road distance is 242.6 miles.
The best way to get from St. Louis to Indianapolis without a car is to bus which takes 4h 25m and costs $30 - $65.
The bus from St Louis Bus Station to Indianapolis, Illinois St (Greyhound Bus Station) takes 4h 25m including transfers and departs three times a day.
St. Louis to Indianapolis bus services, operated by Greyhound USA, depart from St Louis Bus Station.
St. Louis to Indianapolis train services, operated by Amtrak, depart from St. Louis station.
The best way to get from St. Louis to Indianapolis is to bus which takes 4h 25m and costs $30 - $65. Alternatively, you can train, which costs $70 - $210 and takes 10h 49m, you could also fly, which costs $290 - $600 and takes 5h 47m.
What companies run services between St. Louis, MO, USA and Indianapolis, IN, USA?
Greyhound USA operates a bus from St Louis Bus Station to Indianapolis Union Station 3 times a day. Tickets cost $30–65 and the journey takes 4h 25m. Alternatively, you can take a train from St. Louis to Indianapolis via Chicago Union Station in around 10h 49m.
- Website
- delta.com
Flights from Lambert–St. Louis International Airport to Indianapolis via Detroit
- Ave. Duration
- 4h 59m
- When
- Every day
- Estimated price
- $110–700
Flights from Lambert–St. Louis International Airport to Indianapolis via Atlanta
- Ave. Duration
- 4h 30m
- When
- Every day
- Estimated price
- $140–750
Flights from Lambert–St. Louis International Airport to Indianapolis via Minneapolis
- Ave. Duration
- 4h 39m
- When
- Every day
- Estimated price
- $140–750
- Website
- united.com
Flights from Lambert–St. Louis International Airport to Indianapolis via Chicago O'Hare
- Ave. Duration
- 4h 1m
- When
- Every day
- Estimated price
- $90–600
- Website
- southwest.com
Flights from Lambert–St. Louis International Airport to Indianapolis via Chicago Midway
- Ave. Duration
- 3h 10m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $90–600
Flights from Lambert–St. Louis International Airport to Indianapolis via Nashville
- Ave. Duration
- 4h 37m
- When
- Sunday
- Estimated price
- $100–650
Flights from Lambert–St. Louis International Airport to Indianapolis via Atlanta
- Ave. Duration
- 4h 20m
- When
- Monday and Sunday
- Estimated price
- $140–750
- Website
- aa.com
Flights from Lambert–St. Louis International Airport to Indianapolis via Chicago O'Hare
- Ave. Duration
- 4h 45m
- When
- Every day
- Estimated price
- $90–600
Flights from Lambert–St. Louis International Airport to Indianapolis via Charlotte
- Ave. Duration
- 5h
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $150–800
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from St. Louis to Chicago Union Station
- Ave. Duration
- 4h 55m
- Frequency
- 5 times a day
- Estimated price
- $40–150
- Website
- https://www.amtrak.com/home.html
Train from Chicago Union Station to Indianapolis
- Ave. Duration
- 4h 54m
- Frequency
- 3 times a week
- Estimated price
- $30–65
- Website
- https://www.amtrak.com/home.html
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from St Louis Bus Station to Indianapolis Union Station
- Ave. Duration
- 4h 25m
- Frequency
- 3 times a day
- Estimated price
- $30–65
- Website
- https://www.greyhound.com/
Want to know more about travelling around United States
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More Questions & Answers
St. Louis to Indianapolis bus services, operated by Greyhound USA, arrive at Indianapolis Union Station.
Indianapolis is 1h ahead of St. Louis. It is currently 7:15 PM in St. Louis and 8:15 PM in Indianapolis.
St. Louis to Indianapolis train services, operated by Amtrak, arrive at Chicago Union Station.
Yes, the driving distance between St. Louis to Indianapolis is 243 miles. It takes approximately 4h 3m to drive from St. Louis to Indianapolis.
Book your St. Louis to Indianapolis train tickets online with Omio.
Book your St. Louis to Indianapolis bus tickets online with Omio and FlixBus.
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