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How to get fromSt. Louis to Guelphby plane, train, train (Amtrak), bus (Greyhound, Flixbus), car, shuttle or bus (Greyhound)

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There are 9 ways to get from St. Louis to Guelph by plane, train, train (Amtrak), bus (Greyhound, Flixbus), car, shuttle, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Toronto Pearson International Airport, train

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Toronto Pearson International Airport (YYZ)plane plane STL - YYZ
    2. Take the train from Bramalea GO to Guelph Central GOtrain train
    7h 6m
    $447–1,021

  2. Bus via Indianapolis

    cheapest
    1. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis, IN to Detroit, MIbus bus
    3. Take the bus from Detroit Bus Station to Kitchenerbus bus
    19h 1m
    $122–299

  3. Train

    1. Take the train from St. Louis to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Port Huron Stationtrain train
    3. Take the train from Sarnia to Guelphtrain train
    17h 26m
    $132–395

  4. Drive 1,129.8 km

    1. Drive from St. Louis to Guelphcar car 1,129.8 km
    12h 16m
    $220–318

  5. Fly to Buffalo Niagara International Airport, shuttle, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Buffalo Niagara International Airport (BUF)plane plane STL - BUF
    2. Take a shuttle bus from Buffalo Airport to Pearson International Airport Terminal 1shuttle bus
    3. Take the train from Bramalea GO to Guelph Central GOtrain train
    10h 20m
    $497–2,281

  6. Fly to Toronto Island Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Toronto Island Airport (YTZ)plane plane STL - YTZ
    2. Take the train from Toronto Union Station to Guelph Central GOtrain train
    9h 54m
    $140–832

  7. Fly to London International Airport, train

    1. Fly from Lambert–St. Louis International Airport (STL) to London International Airport (YXU)plane plane STL - YXU
    2. Take the train from London to Guelphtrain train
    11h 15m
    $388–2,129

  8. Fly to Detroit, shuttle, train

    1. Fly from Lambert–St. Louis International Airport (STL) to Detroit (DTW)plane plane STL - DTW
    2. Take a shuttle bus from Detroit Airport to London, ON - 105, Wharncliffe Road South, Manor Parkshuttle bus
    3. Take the train from London to Guelphtrain train
    11h 4m
    $358–856

  9. Bus

    1. Take the bus from St Louis Bus Station to Pittsburgh Intermodal Stationbus bus
    2. Take the bus from Pittsburgh to Buffalobus bus
    3. Take the bus from Buffalo to Mississaugabus bus
    4. Take the bus from Winston Churchill Transitway Station to Guelph Central GO Busbus bus 29
    26h 49m
    $175–591

St. Louis to Guelph by train and car

Calendar7Weekly Services
Duration17h 26mAverage Duration
Ticket$132Cheapest Price
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Questions & Answers

What companies run services between St. Louis, MO, USA and Guelph, ON, Canada?

You can take a train from St. Louis to Guelph via Chicago Union Station, Port Huron Station, and Sarnia in around 17h 26m. Alternatively, you can take a bus from St Louis Bus Station to Guelph Central GO Bus via Indianapolis, IN, Detroit Bus Station, Kitchener, Kitchener GO Bus, and University of Waterloo Terminal in around 19h 1m.

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