There are 6 ways to get from St. Louis to Great Smoky Mountains by plane, car or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly to Knoxville, drive  •  7 h 6 min

  1. Fly from St. Louis (STL) to Knoxville (TYS) STL - TYS
  2. Drive from Knoxville to Great Smoky Mountains

$208 - $1,112

Cheapest option

Bus, drive via Columbus, Oh  •  25 h 8 min

  1. Take the bus from St Louis, Mo to Columbus, Oh
  2. Take the bus from Columbus, Oh to Winston Salem, Nc
  3. Take the bus from Winston Salem, Nc to Asheville, Nc
  4. Drive from Asheville, Nc to Great Smoky Mountains

$111 - $278

4 alternative options

Fly to Asheville, drive  •  7 h 8 min

  1. Fly from St. Louis (STL) to Asheville (AVL) STL - AVL
  2. Drive from Asheville to Great Smoky Mountains

$220 - $1,114

Fly to Greenville/Spartanburg, drive  •  8 h 13 min

  1. Fly from St. Louis (STL) to Greenville/Spartanburg (GSP) STL - GSP
  2. Drive from Greenville/Spartanburg to Great Smoky Mountains

$176 - $432

Bus, drive  •  27 h 3 min

  1. Take the bus from St Louis, Mo to Atlanta, Ga
  2. Take the bus from Atlanta, Ga to Winston Salem, Nc
  3. Take the bus from Winston Salem, Nc to Asheville, Nc
  4. Drive from Asheville, Nc to Great Smoky Mountains

$119 - $285

Drive  •  9 h 43 min

  1. Drive from St. Louis to Great Smoky Mountains 552.4 miles

$50 - $80

Questions & Answers

The cheapest way to get from St. Louis to Great Smoky Mountains is to drive which costs $50 - $80 and takes 9 h 43 min.

More details

The quickest way to get from St. Louis to Great Smoky Mountains is to fly and drive which costs $200 - $1,200 and takes 7 h 6 min.

More details

The distance between St. Louis and Great Smoky Mountains is 427 miles. The road distance is 552.4 miles.

Get driving directions

It takes approximately 7 h 6 min to get from St. Louis to Great Smoky Mountains, including transfers.

More details

There is no direct flight from St. Louis Airport to Knoxville Airport. The quickest flight takes 3 h 37 min and has one stopover.

Search flights

Great Smoky Mountains is 1 h ahead of St. Louis. It is currently 4:22 AM in St. Louis and 5:22 AM in Great Smoky Mountains.

Yes, the driving distance between St. Louis to Great Smoky Mountains is 552 miles. It takes approximately 9 h 43 min to drive from St. Louis to Great Smoky Mountains.

Get driving directions

United Airlines, American Airlines and Delta offer flights from St. Louis Airport to Knoxville Airport.

Search flights

There are 1268+ hotels available in Great Smoky Mountains. Prices start at $69 USD per night.

More details

The best way to get from St. Louis to St. Louis Airport is to train which takes 31 min and costs $3.

More details

Map of how to get from St. Louis to Great Smoky Mountains.
Launch map view
  • Distance: 426.7 miles
  • Duration: 7 h 6 min

What companies run services between St. Louis, MO, USA and Great Smoky Mountains, TN, USA?

There is no direct connection from St. Louis to Great Smoky Mountains. However, you can take the train to LAMBERT MAIN TRML station, take the walk to St. Louis airport, fly to Knoxville, then take the drive to Great Smoky Mountains. Alternatively, you can take the train to LAMBERT MAIN TRML station, take the walk to St. Louis airport, fly to Asheville, then take the drive to Great Smoky Mountains.

Airlines
Delta
Website
delta.com
Flights from St. Louis to Knoxville via Atlanta
Ave. Duration
4 h 28 min
When
Every day
Estimated price
$200 - $1,100
Flights from St. Louis to Knoxville via Detroit
Ave. Duration
4 h 23 min
When
Every day
Estimated price
$220 - $1,100
Flights from St. Louis to Knoxville via Minneapolis
Ave. Duration
5 h 25 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$250 - $1,200
Flights from St. Louis to Asheville via Atlanta
Ave. Duration
3 h 54 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$210 - $1,100
Flights from St. Louis to Greenville/Spartanburg via Atlanta
Ave. Duration
4 h 7 min
When
Every day
Estimated price
$300 - $460
Flights from St. Louis to Greenville/Spartanburg via Detroit
Ave. Duration
5 h 3 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$300 - $460
American Airlines
Website
aa.com
Flights from St. Louis to Knoxville via Charlotte
Ave. Duration
4 h 21 min
When
Every day
Estimated price
$230 - $1,100
Flights from St. Louis to Knoxville via Chicago O'Hare
Ave. Duration
4 h 32 min
When
Every day
Estimated price
$220 - $1,100
Flights from St. Louis to Knoxville via Dallas/Ft.Worth
Ave. Duration
4 h 57 min
When
Every day
Estimated price
$280 - $1,200
Flights from St. Louis to Asheville via Charlotte
Ave. Duration
4 h 43 min
When
Every day
Estimated price
$220 - $1,100
Flights from St. Louis to Greenville/Spartanburg via Charlotte
Ave. Duration
4 h 10 min
When
Every day
Estimated price
$290 - $450
Flights from St. Louis to Greenville/Spartanburg via Chicago O'Hare
Ave. Duration
4 h 29 min
When
Every day
Estimated price
$290 - $450
Flights from St. Louis to Greenville/Spartanburg via Philadelphia
Ave. Duration
5 h
When
Every day
Estimated price
$290 - $450
Flights from St. Louis to Greenville/Spartanburg via Reagan Washington
Ave. Duration
4 h 59 min
When
Sunday
Estimated price
$290 - $450
United Airlines
Website
united.com
Flights from St. Louis to Knoxville via Chicago O'Hare
Ave. Duration
4 h 31 min
When
Every day
Estimated price
$240 - $1,100
Flights from St. Louis to Knoxville via Washington Dulles
Ave. Duration
4 h 50 min
When
Every day
Estimated price
$270 - $1,200
Flights from St. Louis to Knoxville via Houston
Ave. Duration
5 h 25 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$290 - $1,300
Flights from St. Louis to Asheville via Chicago O'Hare
Ave. Duration
4 h 54 min
When
Every day
Estimated price
$250 - $1,200
Flights from St. Louis to Greenville/Spartanburg via Chicago O'Hare
Ave. Duration
4 h 32 min
When
Every day
Estimated price
$320 - $490
Flights from St. Louis to Greenville/Spartanburg via Washington Dulles
Ave. Duration
4 h 51 min
When
Every day
Estimated price
$320 - $490
Southwest Airlines
Website
southwest.com
Flights from St. Louis to Greenville/Spartanburg via Atlanta
Ave. Duration
4 h 35 min
When
Monday to Friday
Estimated price
$200 - $900
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from St Louis, Mo to Columbus, Oh
Ave. Duration
8 h 5 min
Frequency
Hourly
Estimated price
$40 - $110
Website
greyhound.com
Economy
$40 - $70
Flexible
$80 - $110
Bus from Columbus, Oh to Winston Salem, Nc
Ave. Duration
10 h 35 min
Frequency
Hourly
Estimated price
$40 - $110
Website
greyhound.com
Economy
$40 - $70
Flexible
$80 - $110
Bus from Winston Salem, Nc to Asheville, Nc
Ave. Duration
2 h 55 min
Frequency
Every 2 hours
Estimated price
$20 - $50
Website
greyhound.com
Economy
$20 - $30
Flexible
$35 - $50
Bus from St Louis, Mo to Atlanta, Ga
Ave. Duration
13 h 40 min
Frequency
Every 4 hours
Estimated price
$55 - $140
Website
greyhound.com
Economy
$55 - $90
Flexible
$100 - $140
Bus from Atlanta, Ga to Winston Salem, Nc
Ave. Duration
6 h 40 min
Frequency
Hourly
Estimated price
$35 - $85
Website
greyhound.com
Economy
$35 - $55
Flexible
$65 - $85

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.