There are 6 ways to get from St. Louis to Gatlinburg by plane, taxi, car, bus or night bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly to Knoxville, taxi  •  6 h 12 min

  1. Fly from St. Louis (STL) to Knoxville (TYS) STL - TYS
  2. Take a taxi from Knoxville to Gatlinburg

$402 - $1,342

Cheapest option

Fly to Tri-Cities Regional, drive  •  7 h 11 min

  1. Fly from St. Louis (STL) to Tri-Cities Regional (TRI) STL - TRI
  2. Drive from Tri-Cities Regional to Gatlinburg

$212 - $1,018

4 alternative options

Fly to Asheville, drive  •  7 h 1 min

  1. Fly from St. Louis (STL) to Asheville (AVL) STL - AVL
  2. Drive from Asheville to Gatlinburg

$220 - $1,116

Bus, Megabus, taxi  •  13 h 32 min

  1. Take the bus from St Louis, Mo to Nashville, Tn
  2. Take the bus from Nashville, TN to Chattanooga
  3. Take the Megabus from Chattanooga to Knoxville
  4. Take a taxi from Knoxville to Gatlinburg

$241 - $362

Night bus, bus, Megabus, taxi  •  13 h 46 min

  1. Take the night bus from St Louis, Mo to Nashville, Tn
  2. Take the bus from Nashville, TN to Chattanooga
  3. Take the Megabus from Chattanooga to Knoxville
  4. Take a taxi from Knoxville to Gatlinburg

$245 - $363

Drive  •  8 h 48 min

  1. Drive from St. Louis to Gatlinburg 528.7 miles

$50 - $75

Questions & Answers

The cheapest way to get from St. Louis to Gatlinburg is to drive which costs $50 - $75 and takes 8 h 48 min.

More details

The quickest way to get from St. Louis to Gatlinburg is to fly and taxi which costs $400 - $1,400 and takes 6 h 12 min.

More details

The distance between St. Louis and Gatlinburg is 422 miles. The road distance is 528.7 miles.

Get driving directions

It takes approximately 6 h 12 min to get from St. Louis to Gatlinburg, including transfers.

More details

What companies run services between St. Louis, MO, USA and Gatlinburg, TN, USA?

There is no direct connection from St. Louis to Gatlinburg. However, you can take the train to LAMBERT MAIN TRML station, take the walk to St. Louis airport, fly to Knoxville, then take the taxi to Gatlinburg. Alternatively, you can take the train to LAMBERT MAIN TRML station, take the walk to St. Louis airport, fly to Asheville, then take the drive to Gatlinburg.

Airlines
Delta
Website
delta.com
Flights from St. Louis to Knoxville via Atlanta
Ave. Duration
4 h 16 min
When
Every day
Estimated price
$200 - $1,100
Flights from St. Louis to Knoxville via Detroit
Ave. Duration
4 h 31 min
When
Every day
Estimated price
$220 - $1,100
Flights from St. Louis to Asheville via Atlanta
Ave. Duration
4 h 24 min
When
Every day
Estimated price
$210 - $1,100
Flights from St. Louis to Tri-Cities Regional via Atlanta
Ave. Duration
5 h 5 min
When
Every day
Estimated price
$200 - $1,000
Flights from St. Louis to Tri-Cities Regional via Covington, Atlanta
Ave. Duration
7 h 5 min
When
Monday to Friday
Estimated price
$210 - $1,100
American Airlines
Website
aa.com
Flights from St. Louis to Knoxville via Charlotte
Ave. Duration
4 h 15 min
When
Every day
Estimated price
$230 - $1,100
Flights from St. Louis to Knoxville via Chicago O'Hare
Ave. Duration
3 h 57 min
When
Every day
Estimated price
$220 - $1,100
Flights from St. Louis to Knoxville via Dallas/Ft.Worth
Ave. Duration
4 h 53 min
When
Every day
Estimated price
$280 - $1,200
Flights from St. Louis to Knoxville via Reagan Washington
Ave. Duration
5 h 20 min
When
Every day
Estimated price
$260 - $1,200
Flights from St. Louis to Asheville via Charlotte
Ave. Duration
4 h 31 min
When
Every day
Estimated price
$220 - $1,100
Flights from St. Louis to Tri-Cities Regional via Charlotte
Ave. Duration
4 h 49 min
When
Every day
Estimated price
$210 - $1,000
Flights from St. Louis to Tri-Cities Regional via Chicago O'Hare, Charlotte
Ave. Duration
6 h 37 min
When
Every day
Estimated price
$240 - $1,100
Flights from St. Louis to Tri-Cities Regional via Reagan Washington, Charlotte
Ave. Duration
7 h 18 min
When
Saturday
Estimated price
$250 - $1,100
United Airlines
Website
united.com
Flights from St. Louis to Knoxville via Chicago O'Hare
Ave. Duration
4 h 27 min
When
Every day
Estimated price
$240 - $1,100
Flights from St. Louis to Knoxville via Washington Dulles
Ave. Duration
5 h
When
Every day
Estimated price
$270 - $1,200
Flights from St. Louis to Asheville via Chicago O'Hare
Ave. Duration
5 h 28 min
When
Every day
Estimated price
$250 - $1,200
Flights from St. Louis to Asheville via Newark
Ave. Duration
5 h 58 min
When
Every day
Estimated price
$300 - $1,300
Bus operators
Greyhound USA
Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from St Louis, Mo to Nashville, Tn
Ave. Duration
5 h 40 min
Frequency
Hourly
Estimated price
$35 - $85
Website
greyhound.com
Economy
$35 - $55
Flexible
$65 - $85
Megabus
Phone
877-462-6342
Website
us.megabus.com
Bus from Nashville, TN to Chattanooga
Ave. Duration
2 h 37 min
Frequency
Twice daily
Estimated price
$14 - $25
Schedules at
us.megabus.com
Bus from Chattanooga to Knoxville
Ave. Duration
2 h
Frequency
Twice daily
Estimated price
$12 - $22
Schedules at
us.megabus.com
Other operators
Taxi from Knoxville to Gatlinburg
Ave. Duration
1 h 4 min
Estimated price
$200 - $240
Knoxville Taxi Service
Phone
+1 865 691 1900
Website
knoxvilletaxicab.com

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