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How to get fromSt. Louis to Durhamby plane, bus, bus (Flixbus, Greyhound), train (Amtrak), car or bus (Greyhound)

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There are 5 ways to get from St. Louis to Durham by plane, bus, bus (Flixbus, Greyhound), train (Amtrak), car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly, bus, line 700 bus

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Raleigh-Durham International Airport (RDU)planeSTL - RDU
    2. Take the bus from RDU Airport at Terminal 2 to Regional Transit Centerbus
    3. Take the bus from Regional Transit Center to Durham Station Gate Jbus
    4h 53m
    $252–466

  2. Bus

    cheapest
    1. Take the bus from St Louis Bus Station to Atlanta Bus StationbusFlixBus N2521
    2. Take the bus from Atlanta Bus Station to DurhambusFlixBus N2471 / ...
    18h 50m
    $108–275

  3. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union StationtrainLincoln Service / ...
    2. Take the train from Chicago Union Station to CarytrainFloridian
    31h 34m
    $229–2,122

  4. Drive 755.9 mi

    1. Drive from St. Louis to Durhamcar755.9 mi
    13h 42m
    $138–200

  5. Bus via Columbus (Greyhound)

    1. Take the bus from St Louis Bus Station to Columbusbus
    2. Take the bus from Columbus to Winston Salem(Trans Center)bus
    3. Take the bus from Winston Salem(Trans Center) to Durhambus
    22h 55m
    $140–261

St. Louis to Durham by bus

Calendar7Weekly Buses
Duration18h 50mAverage Duration
Ticket$108Cheapest Price
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Questions & Answers

What companies run services between St. Louis, MO, USA and Durham, NC, USA?

You can take a bus from St Louis Bus Station to Durham via Atlanta Bus Station in around 18h 50m. Alternatively, you can take a train from St. Louis to Durham Amtrak Station via Chicago Union Station and Cary in around 31h 34m.

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