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How to get fromSt. Louis to Durhamby plane, bus, bus (Flixbus, Greyhound), train (Amtrak), car or bus (Greyhound)

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There are 5 ways to get from St. Louis to Durham by plane, bus, bus (Flixbus, Greyhound), train (Amtrak), car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly, bus, line 700 bus

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Raleigh-Durham International Airport (RDU)plane plane STL - RDU
    2. Take the bus from RDU Airport at Terminal 2 to Regional Transit Centerbus bus
    3. Take the bus from Regional Transit Center to Pettigrew St at Parking Deckbus bus
    4h 49m
    $302–756

  2. Bus

    cheapest
    1. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus FlixBus N2521
    2. Take the bus from Atlanta Bus Station to Durhambus bus FlixBus N2471 / ...
    18h 50m
    $111–233

  3. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union Stationtrain train Lincoln Service / ...
    2. Take the train from Chicago Union Station to Carytrain train Floridian
    32h 3m
    $342–808

  4. Drive 755.9 mi

    1. Drive from St. Louis to Durhamcar car 755.9 mi
    13h 47m
    $138–200

  5. Bus via Columbus (Greyhound)

    1. Take the bus from St Louis Bus Station to Columbusbus bus
    2. Take the bus from Columbus to Winston Salem(Trans Center)bus bus
    3. Take the bus from Winston Salem(Trans Center) to Durhambus bus
    22h 55m
    $155–286

St. Louis to Durham by bus

Calendar7Weekly Buses
Duration18h 50mAverage Duration
Ticket$111Cheapest Price
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Questions & Answers

What companies run services between St. Louis, MO, USA and Durham, NC, USA?

You can take a bus from St Louis Bus Station to Durham via Atlanta Bus Station in around 18h 50m. Alternatively, you can take a train from St. Louis to Pettigrew St at Parking Deck via Chicago Union Station, Cary, Cary Depot, and Regional Transit Center in around 32h 3m.

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