Rome2Rio

How to get fromSt. Louis to Durhamby plane, bus, bus (Flixbus, Greyhound), train (Amtrak), car or bus (Greyhound)

Find Transport to Durham

See all options

There are 5 ways to get from St. Louis to Durham by plane, bus, bus (Flixbus, Greyhound), train (Amtrak), car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly, bus, line 700 bus

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Raleigh-Durham International Airport (RDU)plane plane STL - RDU
    2. Take the bus from RDU Airport at Terminal 2 to Regional Transit Centerbus bus
    3. Take the bus from Regional Transit Center to Durham Station Gate Jbus bus
    4h 58m
    $202–466

  2. Bus

    cheapest
    1. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus FlixBus N2521
    2. Take the bus from Atlanta Bus Station to Durhambus bus FlixBus N2471 / ...
    18h 50m
    $107–237

  3. Train (Amtrak)

    1. Take the train from St. Louis to Chicago Union Stationtrain train Lincoln Service / ...
    2. Take the train from Chicago Union Station to Carytrain train Floridian
    31h 34m
    $188–1,538

  4. Drive 755.9 mi

    1. Drive from St. Louis to Durhamcar car 755.9 mi
    13h 47m
    $138–200

  5. Bus via Columbus (Greyhound)

    1. Take the bus from St Louis Bus Station to Columbusbus bus
    2. Take the bus from Columbus to Winston Salem(Trans Center)bus bus
    3. Take the bus from Winston Salem(Trans Center) to Durhambus bus
    22h 55m
    $170–347

St. Louis to Durham by bus

Calendar7Weekly Buses
Duration18h 50mAverage Duration
Ticket$107Cheapest Price
See schedules

Questions & Answers

What companies run services between St. Louis, MO, USA and Durham, NC, USA?

You can take a bus from St Louis Bus Station to Durham via Atlanta Bus Station in around 18h 50m. Alternatively, you can take a train from St. Louis to Durham Amtrak Station via Chicago Union Station and Cary in around 31h 34m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers

Trips from St. Louis

Trips to Durham

Popular routes