There are 5 ways to get from St. Louis to Detroit, MI by plane, bus (Greyhound), train (Amtrak), car, or bus (Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly
best- Fly from Lambert–St. Louis International Airport (STL) to Detroit (DTW)plane STL - DTW
4h 34m$224–444Bus
cheapest- Take the bus from St Louis Bus Station to Indianapolis Union Stationbus Greyhound US0421
- Take the bus from Indianapolis, IN to Detroit, MIbus Cincinnati
10h 30m$61–121Train (Amtrak)
- Take the train from St. Louis to Chicago Union Stationtrain Lincoln Service / ...
- Take the train from Chicago Union Station to Detroittrain Wolverine
11h 48m$83–226Drive 516.7 mi
- Drive from St. Louis to Detroit, MIcar 516.7 mi
8h 52m$95–137Bus via Auburn Gresham (Flixbus)
- Take the bus from St Louis Bus Station to Chicagobus FlixBus N2521
- Take the bus from Chicago to Detroit Bus Stationbus FlixBus 2552
14h 20m$79–148
St. Louis to Detroit, MI by bus
Questions & Answers
The cheapest way to get from St. Louis to Detroit, MI is to bus which costs $60 - $130 and takes 10h 30m.
The fastest way to get from St. Louis to Detroit, MI is to fly which takes 4h 34m and costs $220 - $450.
No, there is no direct bus from St. Louis station to Detroit, MI. However, there are services departing from St Louis Bus Station and arriving at Detroit, MI via Indianapolis, IN. The journey, including transfers, takes approximately 10h 30m.
The distance between St. Louis and Detroit, MI is 479 miles. The road distance is 519.8 miles.
The best way to get from St. Louis to Detroit, MI without a car is to bus which takes 10h 30m and costs $60 - $130.
It takes approximately 4h 34m to get from St. Louis to Detroit, MI, including transfers.
St. Louis to Detroit, MI bus services, operated by Greyhound USA, depart from St Louis Bus Station.
The best way to get from St. Louis to Detroit, MI is to fly which takes 4h 34m and costs $220 - $450. Alternatively, you can bus, which costs $60 - $130 and takes 10h 30m, you could also train, which costs $80 - $230 and takes 11h 48m.
St. Louis to Detroit, MI bus services, operated by Greyhound USA, arrive at Indianapolis Union Station.
Detroit, MI is 2h behind St. Louis. It is currently 7:22 PM in St. Louis and 5:22 PM in Detroit, MI.
What companies run services between St. Louis, MO, USA and Detroit, MI, USA?
Delta and Southwest Airlines fly from Lambert–St. Louis International Airport (STL) to Detroit (DTW) 5 times a day. Alternatively, you can take a bus from St Louis Bus Station to Detroit, MI via Indianapolis, IN in around 10h 30m.
- Website
- southwest.com
Flights from Lambert–St. Louis International Airport to Detroit
- Ave. Duration
- 1h 40m
- When
- Every day
- Estimated price
- $80–500
Flights from Lambert–St. Louis International Airport to Detroit via Nashville
- Ave. Duration
- 3h 55m
- When
- Monday, Thursday, and Saturday
- Estimated price
- $100–600
Flights from Lambert–St. Louis International Airport to Detroit via Chicago Midway
- Ave. Duration
- 4h
- When
- Monday, Thursday, and Friday
- Estimated price
- $85–550
- Website
- delta.com
Flights from Lambert–St. Louis International Airport to Detroit
- Ave. Duration
- 1h 35m
- When
- Every day
- Estimated price
- $80–500
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from St. Louis to Chicago Union Station
- Ave. Duration
- 4h 55m
- Frequency
- 5 times a day
- Estimated price
- $35–110
- Website
- https://www.amtrak.com/home.html
Train from Chicago Union Station to Detroit
- Ave. Duration
- 5h 20m
- Frequency
- 3 times a day
- Estimated price
- $45–120
- Website
- https://www.amtrak.com/home.html
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from St Louis Bus Station to Indianapolis Union Station
- Ave. Duration
- 4h 25m
- Frequency
- 3 times a day
- Estimated price
- $30–55
- Website
- https://www.greyhound.com/
- Phone
- +1 888-378-3823
- info@baronsbus.com
- Website
- baronsbus.com
Bus from Indianapolis, IN to Detroit, MI
- Ave. Duration
- 5h 5m
- Frequency
- Once daily
- Estimated price
- $27–70
- Website
- https://baronsbus.com
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from St Louis Bus Station to Chicago
- Ave. Duration
- 5h 50m
- Frequency
- Twice daily
- Estimated price
- $35–75
- Schedules at
- flixbus.com
Bus from Chicago to Detroit Bus Station
- Ave. Duration
- 7h 30m
- Frequency
- Once daily
- Estimated price
- $40–75
- Schedules at
- flixbus.com
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Why you should take the train in the US
Read the travel guide
More Questions & Answers
Yes, the driving distance between St. Louis to Detroit, MI is 520 miles. It takes approximately 8h 52m to drive from St. Louis to Detroit, MI.
Book your St. Louis to Detroit, MI bus tickets online with Omio.
There are 472+ hotels available in Detroit, MI.













