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There are 7 ways to get from St. Louis to Destin by plane, taxi, train, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly St. Louis to Valparaiso  •  5 h 30 min

  1. Fly from St. Louis (STL) to Valparaiso (VPS) STL - VPS

$262 - $1,158

Cheapest option

Train to Belleville, fly to Valparaiso  •  5 h 7 min

  1. Take the train from CONVENTION CENTER station to SHILOH-SCOTT station
  2. Fly from Belleville (BLV) to Valparaiso (VPS) BLV - VPS

$140 - $400

5 alternative options

Fly St. Louis to Panama City, taxi  •  4 h 28 min

  1. Fly from St. Louis (STL) to Panama City (ECP) STL - ECP
  2. Take a taxi from Panama City to Destin

$372 - $1,452

Fly St. Louis to Pensacola, taxi  •  6 h 17 min

  1. Fly from St. Louis (STL) to Pensacola (PNS) STL - PNS
  2. Take a taxi from Pensacola to Destin

$282 - $592

Amtrak Thruway, train, bus, taxi  •  24 h 12 min

  1. Take the Amtrak Thruway from St. Louis, MO - Amtrak to Carbondale,IL - Amtrak
  2. Take the train from Carbondale Amtrak to New Orleans Union Passenger Terminal
  3. Take the bus from New Orleans, La to Pensacola, Fl
  4. Take a taxi from Pensacola, Fl to Destin

$254 - $485

Bus, taxi  •  26 h 56 min

  1. Take the bus from St Louis, Mo to Tallahassee, Fl
  2. Take the bus from Tallahassee, Fl to Pensacola, Fl
  3. Take a taxi from Pensacola, Fl to Destin

$254 - $462

Drive  •  13 h 10 min

  1. Drive from St. Louis to Destin 761 miles

$70 - $110

Questions & Answers

The cheapest way to get from St. Louis to Destin is to drive which costs $70 - $110 and takes 13 h 10 min.

More details

The quickest way to get from St. Louis to Destin is to fly and taxi which costs $370 - $1,500 and takes 4 h 28 min.

More details

The distance between St. Louis and Destin is 610 miles. The road distance is 761 miles.

Get driving directions

The best way to get from St. Louis to Destin without a car is to Amtrak Thruway and train and bus and taxi which takes 24 h 12 min and costs $250 - $490.

More details

It takes approximately 5 h 30 min to get from St. Louis to Destin, including transfers.

More details

There is no direct flight from St. Louis Airport to Valparaiso Airport. The quickest flight takes 3 h 33 min and has one stopover.

Search flights

Yes, the driving distance between St. Louis to Destin is 761 miles. It takes approximately 13 h 10 min to drive from St. Louis to Destin.

Get driving directions

United Airlines, American Airlines and Delta offer flights from St. Louis Airport to Valparaiso Airport.

Search flights

There are 2192+ hotels available in Destin. Prices start at $87 USD per night.

More details

The best way to get from St. Louis to St. Louis Airport is to train which takes 31 min and costs $3.

More details

Map of how to get from St. Louis to Destin.
Launch map view
  • Distance: 610.1 miles
  • Duration: 5 h 30 min

What companies run services between St. Louis, MO, USA and Destin, FL, USA?

Delta, American Airlines and United Airlines fly from St. Louis to Destin hourly.

Airlines
Delta
Website
delta.com
Flights from St. Louis to Valparaiso via Atlanta
Ave. Duration
3 h 58 min
When
Every day
Estimated price
$220 - $1,100
Flights from St. Louis to Panama City via Atlanta
Ave. Duration
3 h 59 min
When
Every day
Estimated price
$250 - $1,300
Flights from St. Louis to Pensacola via Atlanta
Ave. Duration
4 h 26 min
When
Every day
Estimated price
$350 - $1,100
American Airlines
Website
aa.com
Flights from St. Louis to Valparaiso via Charlotte
Ave. Duration
4 h 44 min
When
Every day
Estimated price
$270 - $1,200
Flights from St. Louis to Valparaiso via Dallas/Ft.Worth
Ave. Duration
6 h 5 min
When
Every day
Estimated price
$280 - $1,200
Flights from St. Louis to Valparaiso via Chicago O'Hare
Ave. Duration
5 h 9 min
When
Saturday
Estimated price
$270 - $1,200
Flights from St. Louis to Pensacola via Charlotte
Ave. Duration
4 h 36 min
When
Tuesday
Estimated price
$310 - $850
Flights from St. Louis to Pensacola via Chicago O'Hare
Ave. Duration
4 h 59 min
When
Saturday
Estimated price
$310 - $850
Flights from St. Louis to Pensacola via Dallas/Ft.Worth
Ave. Duration
5 h 39 min
When
Every day
Estimated price
$310 - $850
Flights from St. Louis to Pensacola via Miami
Ave. Duration
6 h
When
Every day
Estimated price
$310 - $850
Flights from St. Louis to Pensacola via Philadelphia
Ave. Duration
6 h 49 min
When
Every day
Estimated price
$310 - $850
Flights from St. Louis to Pensacola via Reagan Washington
Ave. Duration
6 h 52 min
When
Every day
Estimated price
$310 - $850
United Airlines
Website
united.com
Flights from St. Louis to Valparaiso via Houston
Ave. Duration
5 h 27 min
When
Every day
Estimated price
$290 - $1,300
Flights from St. Louis to Pensacola via Houston
Ave. Duration
5 h 30 min
When
Every day
Estimated price
$330 - $900
Flights from St. Louis to Pensacola via Chicago O'Hare
Ave. Duration
5 h 55 min
When
Saturday
Estimated price
$330 - $900
Southwest Airlines
Website
southwest.com
Flights from St. Louis to Panama City
Ave. Duration
1 h 45 min
When
Saturday
Estimated price
$280 - $1,200
Flights from St. Louis to Panama City via Nashville
Ave. Duration
4 h 15 min
When
Saturday
Estimated price
$280 - $1,200
Flights from St. Louis to Pensacola via Chicago Midway
Ave. Duration
4 h 5 min
When
Saturday
Estimated price
$450 - $800
Flights from St. Louis to Pensacola via Dallas
Ave. Duration
4 h 30 min
When
Saturday
Estimated price
$450 - $800
Flights from St. Louis to Pensacola via Houston Hobby Apt
Ave. Duration
4 h 35 min
When
Monday to Friday
Estimated price
$450 - $800
Flights from St. Louis to Pensacola via Nashville
Ave. Duration
5 h 42 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$450 - $800
Flights from St. Louis to Pensacola via Kansas City
Ave. Duration
6 h 50 min
When
Saturday
Estimated price
$450 - $800
Allegiant Air
Website
allegiantair.com
Flights from Belleville to Valparaiso
Ave. Duration
1 h 44 min
When
Thursday, Saturday and Sunday
Estimated price
$95 - $340
Train operators
Metro St. Louis
Phone
+1 314-982-1400
Website
metrostlouis.org
Train from CONVENTION CENTER station to SHILOH-SCOTT station
Ave. Duration
38 min
Frequency
Every 20 minutes
Estimated price
$3
Schedules at
metrostlouis.org
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Carbondale Amtrak to New Orleans Union Passenger Terminal
Ave. Duration
14 h 21 min
Frequency
Once daily
Estimated price
$85 - $250
Website
amtrak.com
Coach Seat
$85 - $130
Flexi Coach Seat
$150 - $230
Business Coach Seat
$170 - $250
Room
$370 - $550
Bus operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Bus from St. Louis, MO - Amtrak to Carbondale,IL - Amtrak
Ave. Duration
2 h
Frequency
Twice daily
Website
amtrak.com
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from New Orleans, La to Pensacola, Fl
Ave. Duration
4 h 35 min
Frequency
4 times a day
Estimated price
$25 - $60
Website
greyhound.com
Economy
$25 - $40
Flexible
$45 - $60
Bus from St Louis, Mo to Tallahassee, Fl
Ave. Duration
20 h 25 min
Frequency
Once daily
Estimated price
$85 - $220
Website
greyhound.com
Economy
$85 - $150
Flexible
$160 - $220
Bus from Tallahassee, Fl to Pensacola, Fl
Ave. Duration
4 h 15 min
Frequency
Every 2 hours
Estimated price
$26 - $65
Website
greyhound.com
Economy
$26 - $40
Flexible
$45 - $65
Other operators
Taxi from Panama City to Destin
Ave. Duration
1 h 12 min
Estimated price
$120 - $150
Red Cabs of Panama City
Phone
+1 850-733-2227
Website
myfloridacabs.com
H2O Shuttle Taxi and Limo
Phone
+1 850-708-2870
Emerald Taxi
Phone
+1 850-792-2546
Website
emeraldtaxiandshuttle.com

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