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How to get fromSt. Louis to Defianceby train (Amtrak), bus, taxi, car, plane, or bus (Flixbus, Amtrak)

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There are 5 ways to get from St. Louis to Defiance by train (Amtrak), bus, taxi, car, plane, or bus (Flixbus, Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from St. Louis to Chicago Union Stationtrain train Lincoln Service / ...
    2. Take the train from Chicago Union Station to Bryan Amtrak Stationtrain train Lake Shore Limited
    9h 38m
    $202–371

  2. Drive 406.9 mi

    cheapest
    1. Drive from St. Louis to Defiancecar car 406.9 mi
    7h
    $75–108

  3. Bus, taxi

    1. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Ft Wayne Citilink Central Stationbus bus
    3. Take the taxi from Green Street to Defiancetaxi taxi
    9h 51m
    $167–236

  4. Fly, taxi

    1. Fly from Lambert–St. Louis International Airport (STL) to Fort Wayne International Airport (FWA)plane plane STL - FWA
    2. Take the taxi from Fort Wayne International Airport (FWA) to Defiancetaxi taxi
    6h 10m
    $212–622

  5. Bus

    1. Take the bus from St Louis Bus Station to Chicago Bus Stationbus bus FlixBus 2510 / ...
    2. Take the bus from Chicago Union Station to Bryan Amtrak Stationbus bus Amtrak Thruway Connecting Service
    10h 57m
    $167–248

Lambert–St. Louis International Airport (STL) to Fort Wayne International Airport (FWA) flights

Calendar135Weekly Planes
Duration5h 14mAverage Duration
Ticket$74Cheapest Price
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Questions & Answers

Map of how to get from St. Louis to Defiance.ExpandLaunch map view
  • Distance: 479.2 mi
  • Duration: 9h 38m

What companies run services between St. Louis, MO, USA and Defiance, OH, USA?

You can take a train from St. Louis to Defiance via Chicago Union Station and Bryan Amtrak Station in around 9h 38m. Alternatively, you can take a bus from St Louis Bus Station to Defiance via Chicago Bus Station, Chicago Union Station, and Bryan Amtrak Station in around 10h 57m.

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