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How to get fromSt. Louis to Defianceby train (Amtrak), bus, taxi, car, plane or train

Find Transport to Defiance

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There are 5 ways to get from St. Louis to Defiance by train (Amtrak), bus, taxi, car, plane, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from St. Louis to Chicago Union StationtrainLincoln Service / ...
    2. Take the train from Chicago Union Station to Bryan Amtrak StationtrainLake Shore Limited
    9h 38m
    $136–269

  2. Drive 406.9 mi

    cheapest
    1. Drive from St. Louis to Defiancecar406.9 mi
    6h 56m
    $75–108

  3. Bus, taxi

    1. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus
    2. Take the bus from Indianapolis, IN to Fort Wayne, INbus
    3. Take the bus from Fort Wayne, IN to Van Wertbus
    4. Take the taxi from Van Wert to Defiancetaxi
    10h 7m
    $140–272

  4. Fly, taxi

    1. Fly from Lambert–St. Louis International Airport (STL) to Fort Wayne International Airport (FWA)planeSTL - FWA
    2. Take the taxi from Fort Wayne International Airport (FWA) to Defiancetaxi
    6h 16m
    $218–642

  5. Bus, train

    1. Take the bus from St Louis Bus Station to Chicago Bus StationbusFlixBus N2521 / ...
    2. Take the train from Chicago Union Station to Bryan Amtrak StationtrainLake Shore Limited
    11h 7m
    $132–218

Lambert–St. Louis International Airport (STL) to Fort Wayne International Airport (FWA) flights

Calendar98Weekly Planes
Duration5h 17mAverage Duration
Ticket$75Cheapest Price
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Questions & Answers

What companies run services between St. Louis, MO, USA and Defiance, OH, USA?

You can take a train from St. Louis to Defiance via Chicago Union Station and Bryan Amtrak Station in around 9h 38m.

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