There are 7 ways to get from St. Louis to Chicago, IL by train (Amtrak), bus (Flixbus), car, plane, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train (Amtrak)
best- Take the train from St. Louis to Chicago Union Stationtrain Lincoln Service / ...
5h 4m$40–280Bus (Flixbus)
cheapest- Take the bus from St Louis Bus Station to Chicago Bus Stationbus FlixBus N2521 / ...
6h 15m$35–65Drive 292.1 mi
- Drive from St. Louis to Chicago, ILcar 292.1 mi
5h 3m$54–77Fly Lambert–St. Louis International Airport to Chicago Midway International Airport
- Fly from Lambert–St. Louis International Airport (STL) to Chicago Midway International Airport (MDW)plane STL - MDW
3h 33m$80–558Fly Lambert–St. Louis International Airport to Chicago O'Hare International Airport
- Fly from Lambert–St. Louis International Airport (STL) to Chicago O'Hare International Airport (ORD)plane STL - ORD
3h 53m$204–498Drive to Decatur Airport, fly to Chicago O'Hare International Airport
- Drive from St. Louis to Decatur Airport (DEC)car
- Fly from Decatur Airport (DEC) to Chicago O'Hare International Airport (ORD)plane DEC - ORD
4h 46m$54–267Train to Abraham Lincoln Capital Airport, fly to Chicago O'Hare International Airport
- Take the train from St. Louis to Springfieldtrain
- Fly from Abraham Lincoln Capital Airport (SPI) to Chicago O'Hare International Airport (ORD)plane SPI - ORD
5h 2m$63–302
St. Louis to Chicago, IL by train and foot (Amtrak)
Questions & Answers
The cheapest way to get from St. Louis to Chicago, IL is to bus which costs $35 - $65 and takes 6h 15m.
The fastest way to get from St. Louis to Chicago, IL is to fly which takes 3h 33m and costs $75 - $600.
Yes, there is a direct bus departing from St Louis Bus Station station and arriving at Chicago Bus Station station. Services depart three times a day, and operate every day. The journey takes approximately 6h 15m.
Yes, there is a direct train departing from St. Louis and arriving at Chicago Union Station station. Services depart five times a day, and operate every day. The journey takes approximately 4h 55m.
The distance between St. Louis and Chicago, IL is 283 miles. The road distance is 293.8 miles.
The best way to get from St. Louis to Chicago, IL without a car is to train which takes 5h 4m and costs $40 - $280.
The train from St. Louis to Chicago Union Station takes 4h 55m including transfers and departs five times a day.
St. Louis to Chicago, IL bus services, operated by Flixbus USA, depart from St Louis Bus Station.
St. Louis to Chicago, IL train services, operated by Amtrak, depart from St. Louis station.
The best way to get from St. Louis to Chicago, IL is to train which takes 5h 4m and costs $40 - $280. Alternatively, you can bus, which costs $35 - $65 and takes 6h 15m, you could also fly, which costs $75 - $600 and takes 3h 33m.
What companies run services between St. Louis, MO, USA and Chicago, IL, USA?
Amtrak operates a train from St. Louis to Chicago Union Station 5 times a day. Tickets cost $40–280 and the journey takes 4h 55m. Alternatively, Flixbus USA operates a bus from St Louis Bus Station to Chicago Bus Station 3 times a day. Tickets cost $35–65 and the journey takes 6h 15m.
- Website
- united.com
Flights from Lambert–St. Louis International Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 38m
- When
- Every day
- Estimated price
- $50–370
Flights from Decatur Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 16m
- When
- Every day
- Estimated price
- $30–230
- Website
- southwest.com
Flights from Lambert–St. Louis International Airport to Chicago Midway International Airport
- Ave. Duration
- 1h 9m
- When
- Every day
- Estimated price
- $75–550
- Website
- aa.com
Flights from Lambert–St. Louis International Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 27m
- When
- Every day
- Estimated price
- $50–370
Flights from Abraham Lincoln Capital Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 16m
- When
- Every day
- Estimated price
- $30–230
- Website
- gojetairlines.com
Flights from Lambert–St. Louis International Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 35m
- When
- Every day
- Estimated price
- $50–370
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from St. Louis to Chicago Union Station
- Ave. Duration
- 4h 55m
- Frequency
- 5 times a day
- Estimated price
- $40–280
- Website
- https://www.amtrak.com/home.html
Train from St. Louis to Springfield
- Ave. Duration
- 1h 38m
- Frequency
- 5 times a day
- Estimated price
- $17–55
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from St Louis Bus Station to Chicago Bus Station
- Ave. Duration
- 6h 15m
- Frequency
- 3 times a day
- Estimated price
- $35–65
- Schedules at
- flixbus.com
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More Questions & Answers
St. Louis to Chicago, IL bus services, operated by Flixbus USA, arrive at Chicago Bus Station.
St. Louis to Chicago, IL train services, operated by Amtrak, arrive at Chicago Union Station.
Yes, the driving distance between St. Louis to Chicago, IL is 294 miles. It takes approximately 5h 3m to drive from St. Louis to Chicago, IL.
Book your St. Louis to Chicago, IL train tickets online with Omio.
Book your St. Louis to Chicago, IL bus tickets online with Omio and FlixBus.
There are 1254+ hotels available in Chicago, IL.