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There are 6 ways to get from St Louis to Cambridge by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended

Fly to Boston

  1. Fly from St. Louis (STL) to Boston (BOS)

Cheapest

Bus

  1. Take the bus from St Louis to New York
  2. Take the bus from New York, NY to Boston, MA

Fly to Manchester, bus

  1. Fly from St. Louis (STL) to Manchester (MHT)
  2. Take the bus from North Londonderry, NH - exit 5 to Boston South Buses

Fly to Providence, train

  1. Fly from St. Louis (STL) to Providence (PVD)
  2. Take the train from Providence to Boston

Train

  1. Take the train from St. Louis to Chicago Union Station
  2. Take the train from Chicago Union Station to Boston

Drive

  1. Drive from St Louis to Cambridge

St Louis to Cambridge by train

The train journey time between St Louis and Cambridge is around 28h 19m and covers a distance of around 1302 miles. This includes an average layover time of around 1h. Operated by Amtrak, the St Louis to Cambridge train service departs from St. Louis and arrives in Boston. Typically seven trains run weekly, although weekend and holiday schedules can vary so check in advance.

7 Weekly Trains
28h 19m Average Duration
$143 Cheapest Price
See schedules
St Louis → Cambridge
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COVID-19 help in United States

If you need help, visit the national COVID-19 website or call the COVID-19 Helpline 800-232-4636

Frequently Asked Questions


Yes, travel within United States is currently allowed.

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Domestic travel is not restricted, but some conditions may apply

  • Face masks are recommended
  • There is a social distancing requirement of 2 metres
  • Domestic border crossings may be subject to approval, testing and quarantine

Explore travel options

The national COVID-19 helpline number in Cambridge is 800-232-4636.

Wearing a face mask on public transport in Cambridge is recommended.

The social distance requirement in Cambridge is 2 metres.

Make yourself known to an official member of staff and/or call the national coronavirus helpline number on 800-232-4636.

Last updated: 17 May 2022
Exceptions may apply, for full details: Centers for Disease control and prevention (CDC).

We're working around the clock to bring you the latest COVID-19 travel updates.
This information is compiled from official sources. To the best of our knowledge, it is correct as of the last update.
Visit Rome2rio travel advice for general help.

Questions & Answers

The cheapest way to get from St Louis to Cambridge is to drive which costs $110 - $170 and takes 19h 43m.

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The quickest way to get from St Louis to Cambridge is to fly which costs $160 - $340 and takes 4h 31m.

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No, there is no direct bus from St Louis to Cambridge. However, there are services departing from St Louis and arriving at Boston, MA via New York, NY. The journey, including transfers, takes approximately 29h 38m.

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No, there is no direct train from St Louis to Cambridge. However, there are services departing from St. Louis and arriving at Boston via Chicago Union Station. The journey, including transfers, takes approximately 28h 19m.

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The distance between St Louis and Cambridge is 1040 miles. The road distance is 1181.5 miles.

Get driving directions

The best way to get from St Louis to Cambridge without a car is to train which takes 28h 19m and costs $140 - $210.

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It takes approximately 4h 31m to get from St Louis to Cambridge, including transfers.

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St Louis to Cambridge bus services, operated by Greyhound USA, depart from St Louis station.

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St Louis to Cambridge train services, operated by Amtrak, depart from St. Louis station.

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The best way to get from St Louis to Cambridge is to fly which takes 4h 31m and costs $160 - $340. Alternatively, you can train, which costs $140 - $210 and takes 28h 19m, you could also bus, which costs $120 - $180 and takes 29h 38m.

Mode details

Map of how to get from St Louis to Cambridge.
Launch map view
  • Distance: 1039.5 miles
  • Duration: 4h 31m

What companies run services between St Louis, MO, USA and Cambridge, MA, USA?

Southwest Airlines, American Airlines and two other airlines fly from St Louis to Cambridge hourly. Alternatively, you can take a train from St Louis to Cambridge via Chicago Union Station in around 28h 19m.

Airlines
American Airlines
Website
aa.com
Flights from St. Louis to Boston
Ave. Duration
2h 52m
When
Every day
Estimated price
$230 - $650
Flights from St. Louis to Boston via Reagan Washington
Ave. Duration
4h 40m
When
Every day
Estimated price
$230 - $650
Flights from St. Louis to Boston via Chicago O'Hare
Ave. Duration
4h 44m
When
Monday to Saturday
Estimated price
$230 - $650
Flights from St. Louis to Manchester via Philadelphia
Ave. Duration
6h 33m
When
Every day
Estimated price
$190 - $700
Flights from St. Louis to Manchester via Charlotte
Ave. Duration
6h 13m
When
Every day
Estimated price
$200 - $750
Flights from St. Louis to Manchester via Reagan Washington
Ave. Duration
5h 32m
When
Every day
Estimated price
$190 - $700
Flights from St. Louis to Manchester via Chicago O'Hare
Ave. Duration
6h 10m
When
Friday
Estimated price
$190 - $700
Flights from St. Louis to Providence via Philadelphia
Ave. Duration
4h 49m
When
Every day
Estimated price
$220 - $800
Flights from St. Louis to Providence via Charlotte
Ave. Duration
5h 22m
When
Every day
Estimated price
$220 - $800
Flights from St. Louis to Providence via Reagan Washington
Ave. Duration
5h 54m
When
Every day
Estimated price
$220 - $800
Flights from St. Louis to Providence via Chicago O'Hare
Ave. Duration
5h 39m
When
Every day
Estimated price
$220 - $800
Southwest Airlines
Website
southwest.com
Flights from St. Louis to Boston
Ave. Duration
2h 27m
When
Every day
Estimated price
$130 - $420
Flights from St. Louis to Boston via Chicago Midway
Ave. Duration
4h 25m
When
Saturday
Estimated price
$130 - $430
Flights from St. Louis to Boston via Baltimore
Ave. Duration
4h 30m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$130 - $430
Flights from St. Louis to Manchester via Baltimore
Ave. Duration
6h 47m
When
Every day
Estimated price
$150 - $500
Flights from St. Louis to Manchester via Chicago Midway
Ave. Duration
6h 7m
When
Every day
Estimated price
$150 - $490
Flights from St. Louis to Manchester via Orlando
Ave. Duration
6h 25m
When
Saturday
Estimated price
$220 - $700
Flights from St. Louis to Providence via Baltimore
Ave. Duration
5h 50m
When
Every day
Estimated price
$170 - $550
Flights from St. Louis to Providence via Tampa
Ave. Duration
6h 55m
When
Saturday
Estimated price
$250 - $800
Flights from St. Louis to Providence via Chicago Midway
Ave. Duration
7h 25m
When
Saturday
Estimated price
$170 - $600
Flights from St. Louis to Providence via Reagan Washington
Ave. Duration
7h 35m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$170 - $600
Delta
Website
delta.com
Flights from St. Louis to Boston via Detroit
Ave. Duration
4h 26m
When
Every day
Estimated price
$200 - $480
Flights from St. Louis to Providence via Detroit
Ave. Duration
5h 25m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$260 - $650
Flights from St. Louis to Providence via New York La Guardia
Ave. Duration
5h 51m
When
Every day
Estimated price
$260 - $650
Flights from St. Louis to Providence via Minneapolis
Ave. Duration
5h 36m
When
Monday, Friday and Sunday
Estimated price
$300 - $700
Flights from St. Louis to Providence via Atlanta
Ave. Duration
5h 59m
When
Every day
Estimated price
$290 - $700
United Airlines
Website
united.com
Flights from St. Louis to Boston via Newark
Ave. Duration
4h 39m
When
Every day
Estimated price
$280 - $900
Flights from St. Louis to Providence via Washington Dulles
Ave. Duration
4h 34m
When
Every day
Estimated price
$210 - $800
Flights from St. Louis to Providence via Newark
Ave. Duration
6h 22m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$210 - $800
Flights from St. Louis to Providence via Chicago O'Hare
Ave. Duration
7h 20m
When
Every day
Estimated price
$210 - $800
Train operators
Amtrak Northeast Regional

Amtrak’s Northeast Regional train service serves the US’ busy northeast corridor from Virginia to Massachusetts; major stops include Boston, Providence, New York City, Philadelphia, Washington DC and Baltimore. Amenities include Wi-Fi, a quiet car, cafe and business-class seating, and travelling with a small dog or cat is permitted. Book at least 14 days in advance for a cheaper Saver Fare.

Rome2rio's guide to Amtrak Northeast Regional
Contact Details
Phone
+1 800-523-6590
Website
amtrak.com
Train from Providence to Boston
Ave. Duration
38 min
Frequency
Every 3 hours
Estimated price
$13 - $75
Schedules at
amtrak.com
Book at
amtrak.com
Child 2-12 with paid adult
$13 - $40
Reserved Coach Seat
$25 - $75
Business Class Seat
$40 - $100
MBTA
Phone
+1-617-222-3200
Website
mbta.com
Train from Providence to Back Bay
Ave. Duration
1h 6m
Frequency
Hourly
Estimated price
$0 - $12
Website
MBTA
children 11 and under
$0
Adult
$10 - $12
Amtrak Acela

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak Acela
Contact Details
Phone
+1 800-872-7245
Website
amtrak.com
Train from Providence to Boston
Ave. Duration
42 min
Frequency
Every 3 hours
Estimated price
$16 - $90
Website
Amtrak Acela
Business Seat - Child 2-12
$16 - $45
Business Seat - Seniors and Active Military
$28 - $85
Business Seat - Adult
$30 - $90
First Class - Child 2-12
$55 - $90
First Class - Senior Citizens and Active Military
$100 - $160
First Class - Adult
$110 - $180
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 800-872-7245
Website
amtrak.com
Train from St. Louis to Chicago Union Station
Ave. Duration
5h 25m
Frequency
4 times a day
Estimated price
$40 - $60
Website
Amtrak
Coach Seat
$40 - $60
Premium
$210 - $300
Flexi Coach Seat
$75 - $110
Business Seat
$75 - $110
Train from Chicago Union Station to Boston
Ave. Duration
21h 54m
Frequency
Once daily
Estimated price
$100 - $150
Website
Amtrak
Coach Seat
$100 - $150
Premium
$330 - $460
Flexi Coach Seat
$200 - $300
Business Seat
$220 - $310
Bus operators
Boston Express
Phone
1800-639-8080
Email
contact@bostonexpressbus.com
Website
bostonexpressbus.com
Bus from North Londonderry, NH - exit 5 to Boston South Buses
Ave. Duration
1h
Frequency
Hourly
Estimated price
$12 - $18
Schedules at
bostonexpressbus.com
Book at
webstore.bostonexpressbus.com
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from St Louis to New York
Ave. Duration
24h 45m
Frequency
3 times a day
Estimated price
$100 - $140
Website
greyhound.com
Economy
$100 - $140
Flexible
$150 - $220
OurBus
Phone
+1 844-800-6828
Email
pr@ourbus.com
Website
ourbus.com
Bus from New York, NY to Boston, MA
Ave. Duration
3h 53m
Frequency
Once daily
Estimated price
$26 - $35
Book at
ourbus.com

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

More Questions & Answers

The quickest flight from St. Louis Airport to Boston Airport is the direct flight which takes 2h 25m.

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St Louis to Cambridge bus services, operated by OurBus, arrive at Boston, MA station.

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Cambridge is 1h ahead of St Louis. It is currently 3:51 AM in St Louis and 4:51 AM in Cambridge.

St Louis to Cambridge train services, operated by Amtrak, arrive at Boston station.

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Yes, the driving distance between St Louis to Cambridge is 1181 miles. It takes approximately 19h 43m to drive from St Louis to Cambridge.

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Delta, United Airlines, Southwest Airlines and American Airlines offer flights from St. Louis Airport to Boston Airport.

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Book your St Louis to Cambridge train tickets online with Omio.

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There are 331+ hotels available in Cambridge. Prices start at $100 USD per night.

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The best way to get from St Louis to St. Louis Airport is to train which takes 31 min and costs $3.

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