There are 6 ways to get from St Louis to Cambridge by plane, bus, train or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.
Fly to Manchester, bus
-
Fly from St. Louis (STL) to Manchester (MHT)
-
Take the bus from North Londonderry, NH - exit 5 to Boston South Buses
Fly to Providence, train
-
Fly from St. Louis (STL) to Providence (PVD)
-
Take the train from Providence to Boston
Train
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Take the train from St. Louis to Chicago Union Station
-
Take the train from Chicago Union Station to Boston
Drive
-
Drive from St Louis to Cambridge
St Louis to Cambridge by train
The train journey time between St Louis and Cambridge is around 28h 19m and covers a distance of around 1302 miles. This includes an average layover time of around 1h. Operated by Amtrak, the St Louis to Cambridge train service departs from St. Louis and arrives in Boston. Typically seven trains run weekly, although weekend and holiday schedules can vary so check in advance.
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Rules to follow in United States
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Travel within United States
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If you need help, visit the national COVID-19 website or call the COVID-19 Helpline 800-232-4636
Frequently Asked Questions
Yes, travel within United States is currently allowed.
Explore travel optionsDomestic travel is not restricted, but some conditions may apply
- Face masks are recommended
- There is a social distancing requirement of 2 metres
- Domestic border crossings may be subject to approval, testing and quarantine
The national COVID-19 helpline number in Cambridge is 800-232-4636.
Wearing a face mask on public transport in Cambridge is recommended.
The social distance requirement in Cambridge is 2 metres.
Make yourself known to an official member of staff and/or call the national coronavirus helpline number on 800-232-4636.
Last updated: 17 May 2022
Exceptions may apply, for full details: Centers for Disease control and prevention (CDC).
We're working around the clock to bring you the latest COVID-19 travel updates.
This information is compiled from official sources. To the best of our knowledge, it is correct as of the last update.
Visit Rome2rio travel advice for general help.
Questions & Answers
The cheapest way to get from St Louis to Cambridge is to drive which costs $110 - $170 and takes 19h 43m.
The quickest way to get from St Louis to Cambridge is to fly which costs $160 - $340 and takes 4h 31m.
No, there is no direct bus from St Louis to Cambridge. However, there are services departing from St Louis and arriving at Boston, MA via New York, NY. The journey, including transfers, takes approximately 29h 38m.
No, there is no direct train from St Louis to Cambridge. However, there are services departing from St. Louis and arriving at Boston via Chicago Union Station. The journey, including transfers, takes approximately 28h 19m.
The distance between St Louis and Cambridge is 1040 miles. The road distance is 1181.5 miles.
The best way to get from St Louis to Cambridge without a car is to train which takes 28h 19m and costs $140 - $210.
It takes approximately 4h 31m to get from St Louis to Cambridge, including transfers.
St Louis to Cambridge bus services, operated by Greyhound USA, depart from St Louis station.
St Louis to Cambridge train services, operated by Amtrak, depart from St. Louis station.
The best way to get from St Louis to Cambridge is to fly which takes 4h 31m and costs $160 - $340. Alternatively, you can train, which costs $140 - $210 and takes 28h 19m, you could also bus, which costs $120 - $180 and takes 29h 38m.
- Distance: 1039.5 miles
- Duration: 4h 31m
What companies run services between St Louis, MO, USA and Cambridge, MA, USA?
Southwest Airlines, American Airlines and two other airlines fly from St Louis to Cambridge hourly. Alternatively, you can take a train from St Louis to Cambridge via Chicago Union Station in around 28h 19m.
- Website
- aa.com
Flights from St. Louis to Boston
- Ave. Duration
- 2h 52m
- When
- Every day
- Estimated price
- $230 - $650
Flights from St. Louis to Boston via Reagan Washington
- Ave. Duration
- 4h 40m
- When
- Every day
- Estimated price
- $230 - $650
Flights from St. Louis to Boston via Chicago O'Hare
- Ave. Duration
- 4h 44m
- When
- Monday to Saturday
- Estimated price
- $230 - $650
Flights from St. Louis to Manchester via Philadelphia
- Ave. Duration
- 6h 33m
- When
- Every day
- Estimated price
- $190 - $700
Flights from St. Louis to Manchester via Charlotte
- Ave. Duration
- 6h 13m
- When
- Every day
- Estimated price
- $200 - $750
Flights from St. Louis to Manchester via Reagan Washington
- Ave. Duration
- 5h 32m
- When
- Every day
- Estimated price
- $190 - $700
Flights from St. Louis to Manchester via Chicago O'Hare
- Ave. Duration
- 6h 10m
- When
- Friday
- Estimated price
- $190 - $700
Flights from St. Louis to Providence via Philadelphia
- Ave. Duration
- 4h 49m
- When
- Every day
- Estimated price
- $220 - $800
Flights from St. Louis to Providence via Charlotte
- Ave. Duration
- 5h 22m
- When
- Every day
- Estimated price
- $220 - $800
Flights from St. Louis to Providence via Reagan Washington
- Ave. Duration
- 5h 54m
- When
- Every day
- Estimated price
- $220 - $800
Flights from St. Louis to Providence via Chicago O'Hare
- Ave. Duration
- 5h 39m
- When
- Every day
- Estimated price
- $220 - $800
- Website
- southwest.com
Flights from St. Louis to Boston
- Ave. Duration
- 2h 27m
- When
- Every day
- Estimated price
- $130 - $420
Flights from St. Louis to Boston via Chicago Midway
- Ave. Duration
- 4h 25m
- When
- Saturday
- Estimated price
- $130 - $430
Flights from St. Louis to Boston via Baltimore
- Ave. Duration
- 4h 30m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
- Estimated price
- $130 - $430
Flights from St. Louis to Manchester via Baltimore
- Ave. Duration
- 6h 47m
- When
- Every day
- Estimated price
- $150 - $500
Flights from St. Louis to Manchester via Chicago Midway
- Ave. Duration
- 6h 7m
- When
- Every day
- Estimated price
- $150 - $490
Flights from St. Louis to Manchester via Orlando
- Ave. Duration
- 6h 25m
- When
- Saturday
- Estimated price
- $220 - $700
Flights from St. Louis to Providence via Baltimore
- Ave. Duration
- 5h 50m
- When
- Every day
- Estimated price
- $170 - $550
Flights from St. Louis to Providence via Tampa
- Ave. Duration
- 6h 55m
- When
- Saturday
- Estimated price
- $250 - $800
Flights from St. Louis to Providence via Chicago Midway
- Ave. Duration
- 7h 25m
- When
- Saturday
- Estimated price
- $170 - $600
Flights from St. Louis to Providence via Reagan Washington
- Ave. Duration
- 7h 35m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
- Estimated price
- $170 - $600
- Website
- delta.com
Flights from St. Louis to Boston via Detroit
- Ave. Duration
- 4h 26m
- When
- Every day
- Estimated price
- $200 - $480
Flights from St. Louis to Providence via Detroit
- Ave. Duration
- 5h 25m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
- Estimated price
- $260 - $650
Flights from St. Louis to Providence via New York La Guardia
- Ave. Duration
- 5h 51m
- When
- Every day
- Estimated price
- $260 - $650
Flights from St. Louis to Providence via Minneapolis
- Ave. Duration
- 5h 36m
- When
- Monday, Friday and Sunday
- Estimated price
- $300 - $700
Flights from St. Louis to Providence via Atlanta
- Ave. Duration
- 5h 59m
- When
- Every day
- Estimated price
- $290 - $700
- Website
- united.com
Flights from St. Louis to Boston via Newark
- Ave. Duration
- 4h 39m
- When
- Every day
- Estimated price
- $280 - $900
Flights from St. Louis to Providence via Washington Dulles
- Ave. Duration
- 4h 34m
- When
- Every day
- Estimated price
- $210 - $800
Flights from St. Louis to Providence via Newark
- Ave. Duration
- 6h 22m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
- Estimated price
- $210 - $800
Flights from St. Louis to Providence via Chicago O'Hare
- Ave. Duration
- 7h 20m
- When
- Every day
- Estimated price
- $210 - $800
Amtrak’s Northeast Regional train service serves the US’ busy northeast corridor from Virginia to Massachusetts; major stops include Boston, Providence, New York City, Philadelphia, Washington DC and Baltimore. Amenities include Wi-Fi, a quiet car, cafe and business-class seating, and travelling with a small dog or cat is permitted. Book at least 14 days in advance for a cheaper Saver Fare.
Rome2rio's guide to Amtrak Northeast Regional
Contact Details
- Phone
- +1 800-523-6590
- Website
- amtrak.com
Train from Providence to Boston
- Ave. Duration
- 38 min
- Frequency
- Every 3 hours
- Estimated price
- $13 - $75
- Schedules at
- amtrak.com
- Book at
- amtrak.com
- Child 2-12 with paid adult
- $13 - $40
- Reserved Coach Seat
- $25 - $75
- Business Class Seat
- $40 - $100
- Phone
- +1-617-222-3200
- Website
- mbta.com
Train from Providence to Back Bay
- Ave. Duration
- 1h 6m
- Frequency
- Hourly
- Estimated price
- $0 - $12
- Website
- MBTA
- children 11 and under
- $0
- Adult
- $10 - $12
Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.
Rome2rio's guide to Amtrak Acela
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Providence to Boston
- Ave. Duration
- 42 min
- Frequency
- Every 3 hours
- Estimated price
- $16 - $90
- Website
- Amtrak Acela
- Business Seat - Child 2-12
- $16 - $45
- Business Seat - Seniors and Active Military
- $28 - $85
- Business Seat - Adult
- $30 - $90
- First Class - Child 2-12
- $55 - $90
- First Class - Senior Citizens and Active Military
- $100 - $160
- First Class - Adult
- $110 - $180
Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.
Rome2rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from St. Louis to Chicago Union Station
- Ave. Duration
- 5h 25m
- Frequency
- 4 times a day
- Estimated price
- $40 - $60
- Website
- Amtrak
- Coach Seat
- $40 - $60
- Premium
- $210 - $300
- Flexi Coach Seat
- $75 - $110
- Business Seat
- $75 - $110
Train from Chicago Union Station to Boston
- Ave. Duration
- 21h 54m
- Frequency
- Once daily
- Estimated price
- $100 - $150
- Website
- Amtrak
- Coach Seat
- $100 - $150
- Premium
- $330 - $460
- Flexi Coach Seat
- $200 - $300
- Business Seat
- $220 - $310
- Phone
- 1800-639-8080
- contact@bostonexpressbus.com
- Website
- bostonexpressbus.com
Bus from North Londonderry, NH - exit 5 to Boston South Buses
- Ave. Duration
- 1h
- Frequency
- Hourly
- Estimated price
- $12 - $18
- Schedules at
- bostonexpressbus.com
- Book at
- webstore.bostonexpressbus.com
- Phone
- +1 800-639-3317
- info@concordcoachlines.com
- Website
- concordcoachlines.com
Bus from North Londonderry, NH to Boston South Buses
- Ave. Duration
- 1h 5m
- Frequency
- 3 times a day
- Estimated price
- $7 - $21
- Schedules at
- concordcoachlines.com
- Children ages 5-11
- $7 - $11
- Adult
- $15 - $21
Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.
Rome2rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100/1-800-231-2222
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from St Louis to New York
- Ave. Duration
- 24h 45m
- Frequency
- 3 times a day
- Estimated price
- $100 - $140
- Website
- greyhound.com
- Economy
- $100 - $140
- Flexible
- $150 - $220
- Phone
- +1 844-800-6828
- pr@ourbus.com
- Website
- ourbus.com
Bus from New York, NY to Boston, MA
- Ave. Duration
- 3h 53m
- Frequency
- Once daily
- Estimated price
- $26 - $35
- Book at
- ourbus.com
Want to know more about travelling around United States
Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
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Read the travel guideMore Questions & Answers
The quickest flight from St. Louis Airport to Boston Airport is the direct flight which takes 2h 25m.
St Louis to Cambridge bus services, operated by OurBus, arrive at Boston, MA station.
Cambridge is 1h ahead of St Louis. It is currently 3:51 AM in St Louis and 4:51 AM in Cambridge.
St Louis to Cambridge train services, operated by Amtrak, arrive at Boston station.
Yes, the driving distance between St Louis to Cambridge is 1181 miles. It takes approximately 19h 43m to drive from St Louis to Cambridge.
Delta, United Airlines, Southwest Airlines and American Airlines offer flights from St. Louis Airport to Boston Airport.
Book your St Louis to Cambridge train tickets online with Omio.
There are 331+ hotels available in Cambridge. Prices start at $100 USD per night.
The best way to get from St Louis to St. Louis Airport is to train which takes 31 min and costs $3.