There are 5 ways to get from Springfield to Mayo Clinic by plane, train, bus, car, or bus (Flixbus, Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly
best- Fly from Abraham Lincoln Capital Airport (SPI) to Rochester (RST)SPI - RST
6h 41m$65–387Train, bus via Madison
- Take the train from Springfield to Chicago Union Station
- Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campus
- Take the bus from Madison to Rochester
13h 20m$66–212Train, bus
- Take the train from Springfield to Chicago Union Station
- Take the train from Chicago Union Station to St. Paul-Minneapolis
- Take the bus from St. Paul to Rochester
14h 11m$93–312Drive 398.4 mi
- Drive from Springfield to Mayo Clinic398.4 mi
7h 39m$73–105Bus
- Take the bus from Springfield SMTD Transfer Center to Chicago Bus Station
- Take the bus from Chicago Bus Station to Milwaukee Intermodal Station
- Take the bus from Milwaukee to Rochester
14h 8m$83–243
Springfield to Mayo Clinic by train, bus, and foot
Questions & Answers
The cheapest way to get from Springfield to Mayo Clinic is to drive which costs $70 - $110 and takes 7h 39m.
The fastest way to get from Springfield to Mayo Clinic is to fly which takes 6h 41m and costs $65 - $390.
No, there is no direct bus from Springfield to Mayo Clinic. However, there are services departing from Springfield SMTD Transfer Center and arriving at Rochester via Chicago Bus Station and Milwaukee. The journey, including transfers, takes approximately 14h 8m.
The distance between Springfield and Mayo Clinic is 332 miles. The road distance is 400.7 miles.
The best way to get from Springfield to Mayo Clinic without a car is to train and bus via Madison which takes 13h 20m and costs $65 - $220.
It takes approximately 6h 41m to get from Springfield to Mayo Clinic, including transfers.
Springfield to Mayo Clinic bus services, operated by Flixbus USA, depart from Springfield SMTD Transfer Center station.
The best way to get from Springfield to Mayo Clinic is to fly which takes 6h 41m and costs $65 - $390. Alternatively, you can bus, which costs $80 - $250 and takes 14h 8m.
Springfield to Mayo Clinic bus services, operated by Flixbus USA, arrive at Chicago Bus Station.
Yes, the driving distance between Springfield to Mayo Clinic is 401 miles. It takes approximately 7h 39m to drive from Springfield to Mayo Clinic.
What companies run services between Springfield, IL, USA and Mayo Clinic, MN, USA?
American Airlines flies from Abraham Lincoln Capital Airport (SPI) to Rochester (RST) twice daily. Alternatively, you can take a bus from Springfield SMTD Transfer Center to Mayo Clinic via Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 14h 8m.
Transport is disrupted due to the Russia-Ukraine war. Read more
- Website
- aa.com
Flights from Abraham Lincoln Capital Airport to Rochester via Chicago O'Hare
- Ave. Duration
- 5h 29m
- When
- Every day
- Estimated price
- $50–330
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Springfield to Chicago Union Station
- Ave. Duration
- 3h 14m
- Frequency
- 5 times a day
- Estimated price
- $25–80
- Website
- https://www.amtrak.com/home.html
Train from Chicago Union Station to St. Paul-Minneapolis
- Ave. Duration
- 7h 24m
- Frequency
- 3 times a day
- Estimated price
- $60–180
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 608-752-5407
- vangalder@coachusa.com
- Website
- coachusa.com
Bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campus
- Ave. Duration
- 3h 50m
- Frequency
- Hourly
- Estimated price
- $20–40
- Website
- https://www.coachusa.com/van-galder-bus-company
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from Madison to Rochester
- Ave. Duration
- 4h 20m
- Frequency
- Once daily
- Estimated price
- $20–95
- Book at
- https://www.jeffersonlines.com
Bus from St. Paul to Rochester
- Ave. Duration
- 1h 25m
- Frequency
- Once daily
- Estimated price
- $7–55
- Book at
- https://www.jeffersonlines.com
Bus from Milwaukee to Rochester
- Ave. Duration
- 5h 40m
- Frequency
- Once daily
- Estimated price
- $27–120
- Book at
- https://www.jeffersonlines.com
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Springfield SMTD Transfer Center to Chicago Bus Station
- Ave. Duration
- 4h 25m
- Frequency
- 3 times a day
- Estimated price
- $35–75
- Schedules at
- flixbus.com
Bus from Chicago Bus Station to Milwaukee Intermodal Station
- Ave. Duration
- 1h 55m
- Frequency
- 3 times a day
- Estimated price
- $20–28
- Schedules at
- flixbus.com
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Chicago Bus Station to Milwaukee Intermodal Station
- Ave. Duration
- 1h 45m
- Frequency
- 3 times a day
- Estimated price
- $20–50
- Website
- https://www.greyhound.com/
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More Questions & Answers
There are 81+ hotels available in Mayo Clinic.