CrossCountry operates a train from Southampton to Plymouth hourly. Tickets cost $40 - $60 and the journey takes 47 min. Great Western Railway also services this route every 2 hours. Alternatively, National Express operates a bus from Southampton to Plymouth once daily. Tickets cost $17 - $23 and the journey takes 6 h 30 min.
From Southampton Central train to Reading then train to Plymouth. 4 h 20 min £130. From Southampton Central train to Salisbury, train to Exeter St Davids, then train to Plymouth. 4 h 41 min £65. From Southampton bus to Plymouth. 6 h 30 min £16. From Southampton drive to Plymouth. 2 h 49 min £28.