Peter Pan Bus Lines operates a bus from South Station to Framingham hourly. Tickets cost $11 - $16 and the journey takes 23 min. Greyhound USA also services this route 3 times a day. Alternatively, MBTA operates a train from South Station to Framingham hourly. Tickets cost $4 - $10 and the journey takes 51 min.
From Boston, MA - South Station bus to Framingham Flutie Pass, MA. 23 min $15. From South Station train to Framingham. 51 min $8. From South Station taxi to Framingham. 29 min $145. From South Station drive to Framingham. 29 min $2. From South Station Uber to Framingham. 29 min $47.