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How to get fromSouth Portland to Buffaloby plane, bus (Amtrak, Greyhound, Flixbus), bus, train, car or bus (Flixbus)

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There are 9 ways to get from South Portland to Buffalo by plane, bus (Amtrak, Greyhound, Flixbus), bus, train, car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Portland to Buffalo Niagara International Airport

    best
    1. Fly from Portland (PWM) to Buffalo Niagara International Airport (BUF)plane plane PWM - BUF
    7h 33m
    $256–1,510

  2. Bus

    cheapest
    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus
    2. Take the bus from Boston to Syracuse Bus Stationbus bus
    3. Take the bus from Syracuse Bus Station to Buffalobus bus
    14h 20m
    $86–218

  3. Bus, train

    1. Take the bus from Portland, ME to Boston, MA - South Stationbus bus Portland / ...
    2. Take the train from Boston to Buffalo Depew Stationtrain train Lake Shore Limited
    16h 50m
    $174–438

  4. Drive 510.2 mi

    1. Drive from South Portland to Buffalocar car 510.2 mi
    10h 24m
    $94–135

  5. Bus to Boston Logan Airport, fly to Buffalo Niagara International Airport

    1. Take the bus from Portland, ME to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Buffalo Niagara International Airport (BUF)plane plane BOS - BUF
    6h 58m
    $158–890

  6. Fly Portland to Rochester, bus

    1. Fly from Portland (PWM) to Rochester (ROC)plane plane PWM - ROC
    2. Take the bus from Rochester Bus Stop to Buffalobus bus
    8h 50m
    $301–1,155

  7. Bus to Boston Logan Airport, fly to Rochester, bus

    1. Take the bus from Portland, ME to Logan International Airportbus bus
    2. Fly from Boston Logan Airport (BOS) to Rochester (ROC)plane plane BOS - ROC
    3. Take the bus from Rochester Bus Stop to Buffalobus bus
    8h 21m
    $263–835

  8. Bus via New York (Flixbus)

    1. Take the bus from City of Portland to New York Midtownbus bus FlixBus N2615
    2. Take the bus from New York Midtown to Buffalobus bus FlixBus 2686 / ...
    18h 16m
    $104–198

  9. Bus, train via New York

    1. Take the bus from City of Portland to New York Midtownbus bus FlixBus N2615
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train Empire Service / ...
    18h 36m
    $164–368

South Portland to Buffalo by bus

Calendar12Weekly Buses
Duration14h 20mAverage Duration
Ticket$86Cheapest Price
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Questions & Answers

What companies run services between South Portland, ME, USA and Buffalo, NY, USA?

United Airlines, American Airlines, and two other airlines fly from Portland (PWM) to Buffalo Niagara International Airport (BUF) hourly. Alternatively, you can take a bus from Sawyer + Broadway to Buffalo via Congress St + Forest Ave, Portland, ME, Boston, MA - South Station, Boston, and Syracuse Bus Station in around 14h 20m.

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