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There are 6 ways to get from South Carolina to St. Louis by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly from Greenville/Spartanburg  •  4 h 31 min

  1. Fly from Greenville/Spartanburg (GSP) to St. Louis (STL) GSP - STL

$199 - $455

Cheapest option

Bus  •  19 h 40 min

  1. Take the bus from Florence, SC to Atlanta, Ga Fayetteville
  2. Take the bus from Atlanta, Ga to St Louis, Mo 4700 / ...

$93 - $195

4 alternative options

Bus to Charlotte, fly  •  5 h 28 min

  1. Take the bus from White Street Park and Ride to Johnson & Wales Way & 4th St
  2. Fly from Charlotte (CLT) to St. Louis (STL) CLT - STL

$151 - $384

Bus via Savannah, Ga  •  22 h 15 min

  1. Take the bus from Florence, Sc to Savannah, Ga
  2. Take the bus from Savannah, Ga to Atlanta, Ga
  3. Take the bus from Atlanta, Ga to St Louis, Mo

$107 - $263

Train  •  33 h 13 min

  1. Take the train from Florence Amtrak Station to Washington Union Station
  2. Take the train from Washington Union Station to Chicago Union Station
  3. Take the train from Chicago Union Station to St. Louis Gateway Station

$216 - $613

Drive  •  13 h 50 min

  1. Drive from Florence to St. Louis 830.2 miles

$80 - $120

Questions & Answers

The cheapest way to get from South Carolina to St. Louis is to drive which costs $80 - $120 and takes 13 h 50 min.

More details

The quickest way to get from South Carolina to St. Louis is to fly which costs $190 - $460 and takes 4 h 31 min.

More details

No, there is no direct bus from South Carolina to St. Louis. However, there are services departing from Florence, SC and arriving at St Louis, Mo via Atlanta, Ga. The journey, including transfers, takes approximately 19 h 40 min.

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No, there is no direct train from South Carolina station to St. Louis station. However, there are services departing from Florence Amtrak Station and arriving at St. Louis Gateway Station via Washington Union Station and Chicago Union Station. The journey, including transfers, takes approximately 33 h 13 min.

More details

The distance between South Carolina and St. Louis is 646 miles. The road distance is 830.2 miles.

Get driving directions

The best way to get from South Carolina to St. Louis without a car is to bus which takes 19 h 40 min and costs $90 - $200.

More details

It takes approximately 4 h 31 min to get from South Carolina to St. Louis, including transfers.

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South Carolina to St. Louis bus services, operated by Greyhound USA, depart from Florence, Sc station.

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South Carolina to St. Louis train services, operated by Amtrak, arrive at Florence Amtrak Station.

More details

The best way to get from South Carolina to St. Louis is to fly which takes 4 h 31 min and costs $190 - $460. Alternatively, you can bus, which costs $90 - $200 and takes 19 h 40 min, you could also train, which costs $210 - $650 and takes 33 h 13 min.

Mode details

Map of how to get from South Carolina to St. Louis.
Launch map view
  • Distance: 645.9 miles
  • Duration: 4 h 31 min

What companies run services between South Carolina, USA and St. Louis, MO, USA?

Delta, Southwest Airlines and two other airlines fly from Greenville to St. Louis hourly. Alternatively, you can take a bus from Florence to St. Louis via Atlanta, Ga in around 19 h 40 min.

Airlines
American Airlines
Website
aa.com
Flights from Greenville/Spartanburg to St. Louis via Charlotte
Ave. Duration
4 h 44 min
When
Every day
Estimated price
$290 - $450
Flights from Greenville/Spartanburg to St. Louis via Chicago O'Hare
Ave. Duration
5 h 14 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$290 - $450
Flights from Greenville/Spartanburg to St. Louis via Reagan Washington
Ave. Duration
5 h 36 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$290 - $450
Flights from Charlotte to St. Louis
Ave. Duration
2 h 7 min
When
Every day
Estimated price
$180 - $550
Flights from Charlotte to St. Louis via Chicago O'Hare
Ave. Duration
4 h 22 min
When
Monday to Friday
Estimated price
$180 - $550
Delta
Website
delta.com
Flights from Greenville/Spartanburg to St. Louis via Atlanta
Ave. Duration
4 h 34 min
When
Every day
Estimated price
$300 - $460
Flights from Greenville/Spartanburg to St. Louis via Detroit
Ave. Duration
4 h 57 min
When
Monday
Estimated price
$300 - $460
Flights from Charlotte to St. Louis via Atlanta
Ave. Duration
4 h 2 min
When
Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$180 - $550
Southwest Airlines
Website
southwest.com
Flights from Greenville/Spartanburg to St. Louis via Atlanta
Ave. Duration
4 h 10 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$190 - $800
Flights from Charlotte to St. Louis via Nashville
Ave. Duration
3 h 37 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$180 - $550
Flights from Charlotte to St. Louis via Chicago Midway
Ave. Duration
4 h 25 min
When
Saturday
Estimated price
$180 - $550
United Airlines
Website
united.com
Flights from Greenville/Spartanburg to St. Louis via Chicago O'Hare
Ave. Duration
5 h 17 min
When
Every day
Estimated price
$320 - $490
Flights from Greenville/Spartanburg to St. Louis via Washington Dulles
Ave. Duration
4 h 55 min
When
Monday, Wednesday, Thursday, Friday, Saturday and Sunday
Estimated price
$320 - $490
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from Florence Amtrak Station to Washington Union Station
Ave. Duration
8 h 3 min
Frequency
Twice daily
Estimated price
$65 - $180
Website
amtrak.com
Coach Seat
$65 - $100
Flexi Coach Seat
$110 - $170
Business Coach Seat
$120 - $180
Room
$280 - $400
Train from Washington Union Station to Chicago Union Station
Ave. Duration
17 h 40 min
Frequency
Once daily
Estimated price
$100 - $310
Website
amtrak.com
Coach Seat
$100 - $160
Flexi Coach Seat
$190 - $280
Business Coach Seat
$220 - $310
Room
$440 - $600
Train from Chicago Union Station to St. Louis Gateway Station
Ave. Duration
5 h 30 min
Frequency
Every 4 hours
Estimated price
$50 - $130
Website
amtrak.com
Coach Seat
$50 - $75
Flexi Coach Seat
$90 - $130
Business Coach Seat
$90 - $130
Room
$230 - $320
Bus operators
Charlotte Area Transit System
Phone
+1 704-336-7433
Email
telltransit@charlottenc.gov
Website
charlottenc.gov
Bus from White Street Park and Ride to Johnson & Wales Way & 4th St
Ave. Duration
1 h 1 min
Frequency
3 times a day
Estimated price
$3 - $5
Schedules at
charlottenc.gov
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Atlanta, Ga to St Louis, Mo
Ave. Duration
12 h 50 min
Frequency
3 times a day
Estimated price
$55 - $140
Website
greyhound.com
Economy
$55 - $90
Flexible
$100 - $140
Bus from Florence, Sc to Savannah, Ga
Ave. Duration
3 h
Frequency
5 times a day
Estimated price
$22 - $55
Website
greyhound.com
Economy
$22 - $35
Flexible
$40 - $55
Bus from Savannah, Ga to Atlanta, Ga
Ave. Duration
4 h 25 min
Frequency
Every 2 hours
Estimated price
$29 - $70
Website
greyhound.com
Economy
$29 - $50
Flexible
$55 - $70

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

More Questions & Answers

There is no direct flight from Greenville/Spartanburg Airport to St. Louis Airport. The quickest flight takes 3 h 37 min and has one stopover.

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South Carolina to St. Louis bus services, operated by Greyhound USA, arrive at St Louis, Mo station.

More details

St. Louis is 1 h behind South Carolina. It is currently 1:49 PM in South Carolina and 12:49 PM in St. Louis.

South Carolina to St. Louis train services, operated by Amtrak, arrive at St. Louis Gateway Station.

More details

Yes, the driving distance between South Carolina to St. Louis is 830 miles. It takes approximately 13 h 50 min to drive from South Carolina to St. Louis.

Get driving directions

Southwest Airlines, United Airlines, Delta and American Airlines offer flights from Greenville/Spartanburg Airport to St. Louis Airport.

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Book your South Carolina to St. Louis train tickets online with Rome2rio.

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Book your South Carolina to St. Louis bus tickets online with Greyhound, Greyhound and Greyhound.

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There are 200+ hotels available in St. Louis. Prices start at $65 USD per night.

More details

The best way to get from South Carolina to Greenville/Spartanburg Airport is to taxi which takes 18 min and costs $35 - $45.

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