Directions from South Carolina to Missouri

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly Charlotte to Springfield  •  3 h 8 min

  1. CLT - SGF

$384 - $593

Cheapest option

Bus  •  26 h 59 min

$131 - $274

8 alternative options

Fly Charlotte to St. Louis, line 34 bus  •  3 h 25 min

  1. CLT - STL

$222 - $467

Fly Greenville/Spartanburg to St. Louis  •  4 h 55 min

  1. GSP - STL

$200 - $456

Fly Charlotte to Kansas City  •  4 h 33 min

  1. CLT - MCI

$270 - $1,045

Fly Charleston to St. Louis  •  5 h 24 min

  1. CHS - STL

$208 - $610

Bus via Savannah, Ga  •  25 h 47 min

$136 - $333

Train  •  34 h 54 min

$231 - $673

Train via Alexandria Amtrak  •  40 h 39 min

$252 - $712

Drive  •  17 h 58 min

  1. 1078.3 miles

$100 - $160

What companies run services between South Carolina, USA and Missouri, USA?

American Airlines, Delta and United Airlines fly from Rock Hill to Springfield hourly. Alternatively, you can take a bus from Florence to Kansas City via Savannah, Ga, Atlanta, Ga, and St Louis, Mo in around 25 h 47 min.

Airlines
American Airlines
Website
aa.com
Flights from Charlotte to Springfield
Ave. Duration
2 h 23 min
When
Every day
Estimated price
$310 - $850
Flights from Charlotte to Springfield via Chicago O'Hare
Ave. Duration
5 h
When
Every day
Estimated price
$310 - $850
Flights from Charlotte to Springfield via Dallas/Ft.Worth
Ave. Duration
5 h 19 min
When
Every day
Estimated price
$310 - $850
Flights from Charlotte to St. Louis
Ave. Duration
1 h 56 min
When
Every day
Estimated price
$180 - $550
Flights from Charlotte to St. Louis via Chicago O'Hare
Ave. Duration
4 h 28 min
When
Every day
Estimated price
$180 - $550
Flights from Greenville/Spartanburg to St. Louis via Charlotte
Ave. Duration
4 h 41 min
When
Every day
Estimated price
$290 - $450
Flights from Greenville/Spartanburg to St. Louis via Chicago O'Hare
Ave. Duration
5 h 1 min
When
Every day
Estimated price
$290 - $450
Flights from Greenville/Spartanburg to St. Louis via Reagan Washington
Ave. Duration
5 h 16 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$290 - $450
Flights from Charlotte to Kansas City
Ave. Duration
2 h 31 min
When
Every day
Estimated price
$200 - $950
Flights from Charlotte to Kansas City via Chicago O'Hare
Ave. Duration
4 h 43 min
When
Monday to Friday
Estimated price
$220 - $1,000
Flights from Charleston to St. Louis via Charlotte
Ave. Duration
4 h 7 min
When
Every day
Estimated price
$340 - $1,200
Delta
Website
delta.com
Flights from Charlotte to Springfield via Atlanta
Ave. Duration
4 h 36 min
When
Every day
Estimated price
$440 - $900
Flights from Charlotte to St. Louis via Atlanta
Ave. Duration
4 h 5 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$180 - $550
Flights from Charlotte to St. Louis via Detroit
Ave. Duration
4 h 23 min
When
Every day
Estimated price
$180 - $550
Flights from Charlotte to St. Louis via Covington
Ave. Duration
4 h 21 min
When
Monday to Friday
Estimated price
$180 - $550
Flights from Greenville/Spartanburg to St. Louis via Atlanta
Ave. Duration
4 h 25 min
When
Every day
Estimated price
$300 - $460
Flights from Greenville/Spartanburg to St. Louis via Detroit
Ave. Duration
4 h 31 min
When
Every day
Estimated price
$300 - $460
Flights from Charlotte to Kansas City via Atlanta
Ave. Duration
4 h 31 min
When
Every day
Estimated price
$190 - $950
Flights from Charlotte to Kansas City via Detroit
Ave. Duration
4 h 46 min
When
Monday, Wednesday, Friday and Sunday
Estimated price
$210 - $1,000
Flights from Charleston to St. Louis via Atlanta
Ave. Duration
4 h 11 min
When
Every day
Estimated price
$340 - $1,200
Southwest Airlines
Website
southwest.com
Flights from Charlotte to St. Louis via Chicago Midway
Ave. Duration
3 h 55 min
When
Monday to Friday
Estimated price
$180 - $550
Flights from Greenville/Spartanburg to St. Louis via Atlanta
Ave. Duration
4 h 22 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$190 - $800
Flights from Charlotte to Kansas City via Nashville
Ave. Duration
4 h 5 min
When
Saturday
Estimated price
$220 - $900
Flights from Charlotte to Kansas City via Chicago Midway
Ave. Duration
4 h 18 min
When
Monday to Saturday
Estimated price
$240 - $950
Flights from Charleston to St. Louis
Ave. Duration
2 h 15 min
When
Monday to Saturday
Estimated price
$400 - $1,600
Flights from Charleston to St. Louis via Nashville
Ave. Duration
4 h
When
Sunday
Estimated price
$400 - $1,600
Flights from Charleston to St. Louis via Chicago Midway
Ave. Duration
4 h 35 min
When
Sunday
Estimated price
$400 - $1,600
United Airlines
Website
united.com
Flights from Charlotte to Springfield via Chicago O'Hare
Ave. Duration
5 h 6 min
When
Every day
Estimated price
$480 - $1,000
Flights from Charlotte to Springfield via Houston
Ave. Duration
5 h 40 min
When
Sunday
Estimated price
$480 - $1,000
Flights from Greenville/Spartanburg to St. Louis via Chicago O'Hare
Ave. Duration
4 h 52 min
When
Every day
Estimated price
$320 - $490
Flights from Greenville/Spartanburg to St. Louis via Washington Dulles
Ave. Duration
5 h 2 min
When
Every day
Estimated price
$320 - $490
Flights from Charlotte to Kansas City via Chicago O'Hare
Ave. Duration
4 h 49 min
When
Monday to Friday
Estimated price
$230 - $1,100
Flights from Charleston to St. Louis via Chicago O'Hare
Ave. Duration
4 h 36 min
When
Every day
Estimated price
$340 - $1,200
Train operators
Amtrak
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Florence Amtrak to Washington Union Station Amtrak
Ave. Duration
8 h 3 min
Frequency
3 times a day
Estimated price
$65 - $180
Website
amtrak.com
Coach Seat
$65 - $100
Flexi Coach Seat
$110 - $170
Business Coach Seat
$120 - $180
Room
$280 - $400
Train from Washington Union Station Amtrak to Chicago Union Station Amtrak
Ave. Duration
17 h 40 min
Frequency
Once daily
Estimated price
$100 - $310
Website
amtrak.com
Coach Seat
$100 - $160
Flexi Coach Seat
$190 - $280
Business Coach Seat
$220 - $310
Room
$440 - $600
Train from Chicago Union Station Amtrak to Kansas City Amtrak
Ave. Duration
7 h 11 min
Frequency
Twice daily
Estimated price
$65 - $190
Website
amtrak.com
Coach Seat
$65 - $100
Flexi Coach Seat
$120 - $180
Business Coach Seat
$130 - $190
Room
$290 - $410
Train from Florence Amtrak to Alexandria Amtrak
Ave. Duration
7 h 28 min
Frequency
3 times a day
Estimated price
$60 - $170
Website
amtrak.com
Coach Seat
$60 - $95
Flexi Coach Seat
$110 - $170
Business Coach Seat
$120 - $170
Room
$280 - $390
Train from Alexandria Amtrak to Chicago Union Station Amtrak
Ave. Duration
23 h 41 min
Frequency
5 times a week
Estimated price
$120 - $350
Website
amtrak.com
Coach Seat
$120 - $180
Flexi Coach Seat
$210 - $310
Business Coach Seat
$250 - $350
Room
$490 - $700
Bus operators
Metro St. Louis
Website
metrostlouis.org
Bus from North Hanley Transit Center to Earth City Expy @ Pattonville Fire Station Nb
Ave. Duration
17 min
Frequency
Hourly
Estimated price
$2
Schedules at
metrostlouis.org
Greyhound USA
Phone
+1 214-849-8100
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Florence, Sc to Savannah, Ga
Ave. Duration
3 h
Frequency
Every 30 minutes
Estimated price
$22 - $55
Website
greyhound.com
Economy
$22 - $35
Flexible
$40 - $55
Bus from Savannah, Ga to Atlanta, Ga
Ave. Duration
4 h 25 min
Frequency
Every 15 minutes
Estimated price
$29 - $70
Website
greyhound.com
Economy
$29 - $50
Flexible
$55 - $70
Bus from Atlanta, Ga to St Louis, Mo
Ave. Duration
12 h 50 min
Frequency
Hourly
Estimated price
$55 - $140
Website
greyhound.com
Economy
$55 - $90
Flexible
$100 - $140
Bus from St Louis, Mo to Kansas City, Mo
Ave. Duration
4 h 25 min
Frequency
Hourly
Estimated price
$29 - $70
Website
greyhound.com
Economy
$29 - $45
Flexible
$50 - $70

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Questions & Answers

The distance between South Carolina and Missouri is 1224 km. The road distance is 1725 km.

The cheapest way to get from South Carolina to Missouri is to drive which costs $100 - $160 and takes 17 h 58 min.

The quickest way to get from South Carolina to Missouri is to fly which takes 3 h 8 min and costs $380 - $600.

No, there is no direct train from South Carolina to Missouri. However, there are services departing from Florence Amtrak and arriving at Kansas City Amtrak via Washington Union Station Amtrak and Chicago Union Station Amtrak. The journey, including transfers, takes approximately 34 h 54 min.

No, there is no direct bus from South Carolina to Missouri. However, there are services departing from Florence, Sc and arriving at Kansas City, Mo via Savannah, Ga, Atlanta, Ga and St Louis, Mo. The journey, including transfers, takes approximately 25 h 47 min.

It takes approximately 3 h 8 min to get from South Carolina to Missouri, including transfers.