There are 9 ways to get from South Carolina to Missouri by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly Charlotte to Springfield  •  3 h 4 min

  1. Fly from Charlotte (CLT) to Springfield (SGF) CLT - SGF

$384 - $593

Cheapest option

Bus  •  24 h 6 min

  1. Take the bus from Florence, SC to Atlanta, Ga
  2. Take the bus from Atlanta, Ga to St Louis, Mo
  3. Take the bus from St Louis, Mo to Kansas City, Mo

$122 - $265

7 alternative options

Fly Greenville/Spartanburg to Springfield  •  4 h 15 min

  1. Fly from Greenville/Spartanburg (GSP) to Springfield (SGF) GSP - SGF

$262 - $1,162

Fly Charlotte to St. Louis, line 34 bus  •  3 h 25 min

  1. Fly from Charlotte (CLT) to St. Louis (STL) CLT - STL
  2. Take the line 34 bus from North Hanley Transit Center to Earth City Expy @ Pattonville Fire Station Nb

$223 - $468

Fly Greenville/Spartanburg to St. Louis  •  4 h 48 min

  1. Fly from Greenville/Spartanburg (GSP) to St. Louis (STL) GSP - STL

$201 - $457

Fly Charlotte to Kansas City  •  4 h 21 min

  1. Fly from Charlotte (CLT) to Kansas City (MCI) CLT - MCI

$270 - $1,045

Bus via Savannah, Ga  •  25 h 47 min

  1. Take the bus from Florence, Sc to Savannah, Ga
  2. Take the bus from Savannah, Ga to Atlanta, Ga
  3. Take the bus from Atlanta, Ga to St Louis, Mo
  4. Take the bus from St Louis, Mo to Kansas City, Mo

$136 - $333

Train  •  34 h 53 min

  1. Take the train from Florence Amtrak to Washington Union Station
  2. Take the train from Washington Union Station to Chicago Union Station
  3. Take the train from Chicago Union Station to Kansas City Amtrak

$231 - $673

Drive  •  17 h 58 min

  1. Drive from Florence to Kansas City 1078.3 miles

$100 - $160

Questions & Answers

The cheapest way to get from South Carolina to Missouri is to drive which costs $100 - $160 and takes 17 h 58 min.

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The quickest way to get from South Carolina to Missouri is to fly which costs $380 - $600 and takes 3 h 4 min.

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No, there is no direct bus from South Carolina to Missouri. However, there are services departing from Florence, SC and arriving at Kansas City, Mo via Atlanta, Ga and St Louis, Mo. The journey, including transfers, takes approximately 24 h 6 min.

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No, there is no direct train from South Carolina to Missouri. However, there are services departing from Florence Amtrak and arriving at Kansas City Amtrak via Washington Union Station and Chicago Union Station. The journey, including transfers, takes approximately 34 h 53 min.

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The distance between South Carolina and Missouri is 765 miles. The road distance is 1078.3 miles.

Get driving directions

The best way to get from South Carolina to Missouri without a car is to bus which takes 24 h 6 min and costs $120 - $270.

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It takes approximately 3 h 4 min to get from South Carolina to Missouri, including transfers.

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South Carolina to Missouri bus services, operated by Greyhound USA, depart from Florence, Sc station.

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South Carolina to Missouri train services, operated by Amtrak, depart from Florence Amtrak station.

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The best way to get from South Carolina to Missouri is to fly which takes 3 h 4 min and costs $380 - $600. Alternatively, you can bus, which costs $120 - $270 and takes 24 h 6 min, you could also train, which costs $230 - $700 and takes 34 h 53 min.

Mode details

Map of how to get from South Carolina to Missouri.
Launch map view
  • Distance: 764.9 miles
  • Duration: 3 h 4 min

What companies run services between South Carolina, USA and Missouri, USA?

American Airlines, Delta and United Airlines fly from Rock Hill to Springfield hourly. Alternatively, you can take a bus from Florence to Kansas City via Atlanta, Ga and St Louis, Mo in around 24 h 6 min.

Airlines
American Airlines
Website
aa.com
Flights from Charlotte to Springfield
Ave. Duration
2 h 20 min
When
Every day
Estimated price
$310 - $850
Flights from Charlotte to Springfield via Chicago O'Hare
Ave. Duration
4 h 59 min
When
Every day
Estimated price
$310 - $850
Flights from Charlotte to Springfield via Dallas/Ft.Worth
Ave. Duration
5 h 13 min
When
Every day
Estimated price
$310 - $850
Flights from Greenville/Spartanburg to Springfield via Charlotte
Ave. Duration
4 h 49 min
When
Every day
Estimated price
$240 - $1,100
Flights from Greenville/Spartanburg to Springfield via Chicago O'Hare
Ave. Duration
5 h 11 min
When
Every day
Estimated price
$260 - $1,200
Flights from Greenville/Spartanburg to Springfield via Dallas/Ft.Worth
Ave. Duration
6 h 20 min
When
Every day
Estimated price
$280 - $1,200
Flights from Charlotte to St. Louis
Ave. Duration
1 h 54 min
When
Every day
Estimated price
$180 - $550
Flights from Charlotte to St. Louis via Chicago O'Hare
Ave. Duration
4 h 8 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$180 - $550
Flights from Greenville/Spartanburg to St. Louis via Charlotte
Ave. Duration
4 h 10 min
When
Every day
Estimated price
$290 - $450
Flights from Greenville/Spartanburg to St. Louis via Chicago O'Hare
Ave. Duration
4 h 21 min
When
Every day
Estimated price
$290 - $450
Flights from Charlotte to Kansas City
Ave. Duration
2 h 20 min
When
Every day
Estimated price
$200 - $950
Flights from Charlotte to Kansas City via Chicago O'Hare
Ave. Duration
4 h 45 min
When
Every day
Estimated price
$220 - $1,000
Delta
Website
delta.com
Flights from Charlotte to Springfield via Atlanta
Ave. Duration
4 h 44 min
When
Every day
Estimated price
$440 - $900
Flights from Greenville/Spartanburg to Springfield via Atlanta
Ave. Duration
4 h 27 min
When
Every day
Estimated price
$210 - $1,100
Flights from Charlotte to St. Louis via Atlanta
Ave. Duration
3 h 50 min
When
Every day
Estimated price
$180 - $550
Flights from Charlotte to St. Louis via Covington
Ave. Duration
3 h 51 min
When
Monday to Friday
Estimated price
$180 - $550
Flights from Charlotte to St. Louis via Detroit
Ave. Duration
4 h 17 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$180 - $550
Flights from Greenville/Spartanburg to St. Louis via Atlanta
Ave. Duration
4 h 32 min
When
Every day
Estimated price
$300 - $460
Flights from Greenville/Spartanburg to St. Louis via Detroit
Ave. Duration
4 h 31 min
When
Monday, Wednesday, Thursday and Friday
Estimated price
$300 - $460
Flights from Charlotte to Kansas City via Atlanta
Ave. Duration
4 h 29 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$190 - $950
Flights from Charlotte to Kansas City via Detroit
Ave. Duration
4 h 53 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$210 - $1,000
Southwest Airlines
Website
southwest.com
Flights from Charlotte to St. Louis via Nashville
Ave. Duration
3 h 5 min
When
Monday to Friday
Estimated price
$180 - $550
Flights from Charlotte to St. Louis via Chicago Midway
Ave. Duration
4 h
When
Saturday
Estimated price
$180 - $550
Flights from Greenville/Spartanburg to St. Louis via Atlanta
Ave. Duration
4 h 8 min
When
Every day
Estimated price
$190 - $800
Flights from Charlotte to Kansas City via Nashville
Ave. Duration
3 h 52 min
When
Monday to Saturday
Estimated price
$220 - $900
Flights from Charlotte to Kansas City via Chicago Midway
Ave. Duration
4 h 16 min
When
Monday to Saturday
Estimated price
$240 - $950
United Airlines
Website
united.com
Flights from Charlotte to Springfield via Chicago O'Hare
Ave. Duration
4 h 43 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$480 - $1,000
Flights from Greenville/Spartanburg to Springfield via Chicago O'Hare
Ave. Duration
5 h 53 min
When
Every day
Estimated price
$270 - $1,200
Flights from Greenville/Spartanburg to Springfield via Houston
Ave. Duration
6 h 46 min
When
Every day
Estimated price
$300 - $1,300
Flights from Charlotte to St. Louis via Chicago O'Hare
Ave. Duration
4 h 15 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$140 - $500
Flights from Greenville/Spartanburg to St. Louis via Chicago O'Hare
Ave. Duration
4 h 22 min
When
Every day
Estimated price
$320 - $490
Flights from Greenville/Spartanburg to St. Louis via Washington Dulles
Ave. Duration
4 h 35 min
When
Every day
Estimated price
$320 - $490
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Florence Amtrak to Washington Union Station
Ave. Duration
8 h 3 min
Frequency
Twice daily
Estimated price
$65 - $180
Website
amtrak.com
Coach Seat
$65 - $100
Flexi Coach Seat
$110 - $170
Business Coach Seat
$120 - $180
Room
$280 - $400
Train from Washington Union Station to Chicago Union Station
Ave. Duration
17 h 40 min
Frequency
Once daily
Estimated price
$100 - $310
Website
amtrak.com
Coach Seat
$100 - $160
Flexi Coach Seat
$190 - $280
Business Coach Seat
$220 - $310
Room
$440 - $600
Train from Chicago Union Station to Kansas City Amtrak
Ave. Duration
7 h 10 min
Frequency
Twice daily
Estimated price
$65 - $190
Website
amtrak.com
Coach Seat
$65 - $100
Flexi Coach Seat
$120 - $180
Business Coach Seat
$130 - $190
Room
$290 - $410
Bus operators
Metro St. Louis
Phone
+1 314-982-1400
Website
metrostlouis.org
Bus from North Hanley Transit Center to Earth City Expy @ Pattonville Fire Station Nb
Ave. Duration
17 min
Frequency
Hourly
Estimated price
$2
Schedules at
metrostlouis.org
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Atlanta, Ga to St Louis, Mo
Ave. Duration
12 h 50 min
Frequency
Hourly
Estimated price
$55 - $140
Website
greyhound.com
Economy
$55 - $90
Flexible
$100 - $140
Bus from St Louis, Mo to Kansas City, Mo
Ave. Duration
4 h 25 min
Frequency
Hourly
Estimated price
$29 - $70
Website
greyhound.com
Economy
$29 - $45
Flexible
$50 - $70
Bus from Florence, Sc to Savannah, Ga
Ave. Duration
3 h
Frequency
Every 30 minutes
Estimated price
$22 - $55
Website
greyhound.com
Economy
$22 - $35
Flexible
$40 - $55
Bus from Savannah, Ga to Atlanta, Ga
Ave. Duration
4 h 25 min
Frequency
Every 15 minutes
Estimated price
$29 - $70
Website
greyhound.com
Economy
$29 - $50
Flexible
$55 - $70

Want to know more about travelling around United States

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More Questions & Answers

The quickest flight from Charlotte Airport to Springfield Airport is the direct flight which takes 2 h 17 min.

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South Carolina to Missouri bus services, operated by Greyhound USA, arrive at Kansas City, Mo station.

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Missouri is 1 h behind South Carolina. It is currently 11:42 AM in South Carolina and 10:42 AM in Missouri.

South Carolina to Missouri train services, operated by Amtrak, arrive at Kansas City Amtrak station.

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Yes, the driving distance between South Carolina to Missouri is 1078 miles. It takes approximately 17 h 58 min to drive from South Carolina to Missouri.

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United Airlines, Delta and American Airlines offer flights from Charlotte Airport to Springfield Airport.

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Book your South Carolina to Missouri train tickets online with Rome2rio.

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Book your South Carolina to Missouri bus tickets online with Greyhound, Greyhound and two other operators.

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There are two+ hotels available in Missouri. Prices start at $100 USD per night.

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The best way to get from South Carolina to Charlotte Airport is to taxi which takes 35 min and costs $75 - $95.

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