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There are 8 ways to get from South Carolina to Mississippi by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly Greenville/Spartanburg to Columbus Golden Triangle Regional  •  3h 53m

  1. Fly from Greenville/Spartanburg (GSP) to Columbus Golden Triangle Regional (GTR) GSP - GTR

$253 - $1,163

Cheapest option

Bus  •  13h 50m

  1. Take the bus from Florence, SC to Atlanta, Ga Fayetteville
  2. Take the bus from Atlanta, Ga to Jackson, Ms 1523 / ...

$78 - $155

6 alternative options

Bus to Charlotte, fly to Memphis  •  4h 47m

  1. Take the bus from White Street Park and Ride to Johnson & Wales Way & 4th St
  2. Fly from Charlotte (CLT) to Memphis (MEM) CLT - MEM

$174 - $441

Bus to Charlotte, fly to Gulfport/Biloxi  •  4h 59m

  1. Take the bus from White Street Park and Ride to Johnson & Wales Way & 4th St
  2. Fly from Charlotte (CLT) to Gulfport/Biloxi (GPT) CLT - GPT

$248 - $1,324

Bus to Charlotte, fly to Jackson/Vicksburg  •  5h 3m

  1. Take the bus from White Street Park and Ride to Johnson & Wales Way & 4th St
  2. Fly from Charlotte (CLT) to Jackson/Vicksburg (JAN) CLT - JAN

$293 - $526

Bus via Savannah, Ga  •  16h 25m

  1. Take the bus from Florence, Sc to Savannah, Ga
  2. Take the bus from Savannah, Ga to Atlanta, Ga
  3. Take the bus from Atlanta, Ga to Jackson, Ms

$92 - $223

Train  •  31h 35m

  1. Take the train from Florence Amtrak Station to Selma-Smithfield Amtrak Station
  2. Take the train from Selma-Smithfield Amtrak Station to Greensboro Amtrak Station
  3. Take the train from Greensboro Amtrak Station to New Orleans Union Passenger Terminal
  4. Take the train from New Orleans Union Passenger Terminal to Jackson Amtrak Station

$209 - $580

Drive  •  11h 9m

  1. Drive from Florence to Jackson 675.8 miles

$65 - $100

Questions & Answers

The cheapest way to get from South Carolina to Mississippi is to drive which costs $65 - $100 and takes 11h 9m.

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The quickest way to get from South Carolina to Mississippi is to fly which costs $250 - $1,200 and takes 3h 53m.

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No, there is no direct bus from South Carolina to Mississippi. However, there are services departing from Florence, SC and arriving at Jackson, Ms via Atlanta, Ga. The journey, including transfers, takes approximately 13h 50m.

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No, there is no direct train from South Carolina station to Mississippi station. However, there are services departing from Florence Amtrak Station and arriving at Jackson Amtrak Station via Selma-Smithfield Amtrak Station, Greensboro Amtrak Station and New Orleans Union Passenger Terminal. The journey, including transfers, takes approximately 31h 35m.

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The distance between South Carolina and Mississippi is 542 miles. The road distance is 675.8 miles.

Get driving directions

The best way to get from South Carolina to Mississippi without a car is to bus which takes 13h 50m and costs $75 - $160.

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It takes approximately 3h 53m to get from South Carolina to Mississippi, including transfers.

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South Carolina to Mississippi bus services, operated by Greyhound USA, depart from Florence, Sc station.

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South Carolina to Mississippi train services, operated by Amtrak, arrive at Florence Amtrak Station.

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The best way to get from South Carolina to Mississippi is to fly which takes 3h 53m and costs $250 - $1,200. Alternatively, you can bus, which costs $75 - $160 and takes 13h 50m, you could also train, which costs $200 - $600 and takes 31h 35m.

Mode details

Map of how to get from South Carolina to Mississippi.
Launch map view
  • Distance: 542 miles
  • Duration: 3h 53m

What companies run services between South Carolina, USA and Mississippi, USA?

Delta and Southwest Airlines fly from Greenville to Columbus every 4 hours. Alternatively, you can take a bus from Florence to Jackson via Atlanta, Ga in around 13h 50m.

Airlines
Delta
Website
delta.com
Flights from Greenville/Spartanburg to Columbus Golden Triangle Regional via Atlanta
Ave. Duration
3h 53m
When
Every day
Estimated price
$200 - $1,100
Flights from Charlotte to Memphis via Atlanta
Ave. Duration
4h 1m
When
Every day
Estimated price
$310 - $750
Flights from Charlotte to Gulfport/Biloxi via Atlanta
Ave. Duration
4h 23m
When
Every day
Estimated price
$410 - $2,700
Flights from Charlotte to Jackson/Vicksburg via Atlanta
Ave. Duration
4h 11m
When
Every day
Estimated price
$350 - $750
American Airlines
Website
aa.com
Flights from Charlotte to Memphis
Ave. Duration
1h 54m
When
Every day
Estimated price
$330 - $700
Flights from Charlotte to Gulfport/Biloxi
Ave. Duration
2h 2m
When
Every day
Estimated price
$390 - $2,700
Flights from Charlotte to Jackson/Vicksburg
Ave. Duration
2h
When
Every day
Estimated price
$300 - $700
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from Florence Amtrak Station to Selma-Smithfield Amtrak Station
Ave. Duration
2h 13m
Frequency
Once daily
Estimated price
$30 - $75
Website
amtrak.com
Coach Seat
$30 - $50
Flexi Coach Seat
$55 - $85
Business Coach Seat
$50 - $75
Room
$170 - $240
Train from Selma-Smithfield Amtrak Station to Greensboro Amtrak Station
Ave. Duration
2h 29m
Frequency
Once daily
Estimated price
$30 - $70
Website
amtrak.com
Coach Seat
$30 - $45
Flexi Coach Seat
$55 - $80
Business Coach Seat
$45 - $70
Room
$160 - $230
Train from Greensboro Amtrak Station to New Orleans Union Passenger Terminal
Ave. Duration
20h 10m
Frequency
Once daily
Estimated price
$110 - $340
Website
amtrak.com
Coach Seat
$110 - $180
Flexi Coach Seat
$210 - $300
Business Coach Seat
$240 - $340
Room
$470 - $650
Train from New Orleans Union Passenger Terminal to Jackson Amtrak Station
Ave. Duration
3h 43m
Frequency
Twice daily
Estimated price
$35 - $95
Website
amtrak.com
Coach Seat
$35 - $60
Flexi Coach Seat
$70 - $100
Business Coach Seat
$65 - $95
Room
$190 - $270
Bus operators
Charlotte Area Transit System
Phone
+1 704-336-7433
Email
telltransit@charlottenc.gov
Website
charlottenc.gov
Bus from White Street Park and Ride to Johnson & Wales Way & 4th St
Ave. Duration
1h 1m
Frequency
3 times a day
Estimated price
$3 - $5
Schedules at
charlottenc.gov
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Atlanta, Ga to Jackson, Ms
Ave. Duration
7h
Frequency
5 times a day
Estimated price
$40 - $100
Website
greyhound.com
Economy
$40 - $65
Flexible
$75 - $100
Bus from Florence, Sc to Savannah, Ga
Ave. Duration
3h
Frequency
5 times a day
Estimated price
$22 - $55
Website
greyhound.com
Economy
$22 - $35
Flexible
$40 - $55
Bus from Savannah, Ga to Atlanta, Ga
Ave. Duration
4h 25m
Frequency
Every 2 hours
Estimated price
$29 - $70
Website
greyhound.com
Economy
$29 - $50
Flexible
$55 - $70

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

More Questions & Answers

There is no direct flight from Greenville/Spartanburg Airport to Columbus Golden Triangle Regional Airport. The quickest flight takes 3h 27m and has one stopover.

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South Carolina to Mississippi bus services, operated by Greyhound USA, arrive at Jackson, Ms station.

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Mississippi is 1h behind South Carolina. It is currently 1:30 PM in South Carolina and 12:30 PM in Mississippi.

South Carolina to Mississippi train services, operated by Amtrak, arrive at Jackson Amtrak Station.

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Yes, the driving distance between South Carolina to Mississippi is 676 miles. It takes approximately 11h 9m to drive from South Carolina to Mississippi.

Get driving directions

Southwest Airlines and Delta offer flights from Greenville/Spartanburg Airport to Columbus Golden Triangle Regional Airport.

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Book your South Carolina to Mississippi train tickets online with Rome2rio.

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Book your South Carolina to Mississippi bus tickets online with Greyhound, Greyhound and Greyhound.

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There are four+ hotels available in Mississippi. Prices start at $100 USD per night.

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The best way to get from South Carolina to Greenville/Spartanburg Airport is to taxi which takes 18m and costs $35 - $45.

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