There are 9 ways to get from South Carolina to Mississippi by plane, car, bus or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly Charlotte to Memphis  •  2 h 31 min

  1. Fly from Charlotte (CLT) to Memphis (MEM) CLT - MEM

$244 - $523

Cheapest option

Bus  •  13 h 6 min

  1. Take the bus from Florence, SC to Atlanta, Ga Fayetteville
  2. Take the bus from Atlanta, Ga to Jackson, Ms 1523 / ...

$78 - $155

7 alternative options

Fly Charlotte to Gulfport/Biloxi  •  2 h 26 min

  1. Fly from Charlotte (CLT) to Gulfport/Biloxi (GPT) CLT - GPT

$318 - $1,406

Fly Greenville/Spartanburg to Columbus Golden Triangle Regional  •  3 h 30 min

  1. Fly from Greenville/Spartanburg (GSP) to Columbus Golden Triangle Regional (GTR) GSP - GTR

$253 - $1,163

Fly Charlotte to Jackson/Vicksburg  •  2 h 39 min

  1. Fly from Charlotte (CLT) to Jackson/Vicksburg (JAN) CLT - JAN

$363 - $608

Fly Charlotte to Mobile, drive  •  3 h 29 min

  1. Fly from Charlotte (CLT) to Mobile (MOB) CLT - MOB
  2. Drive from Mobile to Biloxi

$273 - $1,102

Bus via Savannah, Ga  •  14 h 30 min

  1. Take the bus from Florence, Sc to Savannah, Ga
  2. Take the bus from Savannah, Ga to Atlanta, Ga
  3. Take the bus from Atlanta, Ga to Birmingham, Al
  4. Take the bus from Birmingham, Al to Jackson, Ms

$100 - $243

Train  •  31 h 35 min

  1. Take the train from Florence Amtrak to Selma-Smithfield Amtrak
  2. Take the train from Selma-Smithfield Amtrak to Greensboro Galyon Transportation Center
  3. Take the train from Greensboro Galyon Transportation Center to New Orleans Union Passenger Terminal
  4. Take the train from New Orleans Union Passenger Terminal to Jackson Amtrak

$209 - $580

Drive  •  11 h 9 min

  1. Drive from Florence to Jackson 675.8 miles

$65 - $100

Questions & Answers

No, there is no direct bus from South Carolina to Mississippi. However, there are services departing from Florence, SC and arriving at Jackson, Ms via Atlanta, Ga. The journey, including transfers, takes approximately 13 h 6 min.

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No, there is no direct train from South Carolina to Mississippi. However, there are services departing from Florence Amtrak and arriving at Jackson Amtrak via Selma-Smithfield Amtrak, Greensboro Galyon Transportation Center and New Orleans Union Passenger Terminal. The journey, including transfers, takes approximately 31 h 35 min.

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The distance between South Carolina and Mississippi is 542 miles. The road distance is 675.8 miles.

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The best way to get from South Carolina to Mississippi without a car is to bus which takes 13 h 6 min and costs .

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It takes approximately 2 h 31 min to get from South Carolina to Mississippi, including transfers.

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South Carolina to Mississippi bus services, operated by Greyhound USA, depart from Florence, Sc station.

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South Carolina to Mississippi train services, operated by Amtrak, depart from Florence Amtrak station.

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The best way to get from South Carolina to Mississippi is to fly which takes 2 h 31 min and costs . Alternatively, you can bus, which costs and takes 13 h 6 min, you could also train, which costs and takes 31 h 35 min.

Mode details

The quickest flight from Charlotte Airport to Memphis Airport is the direct flight which takes 1 h 45 min.

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South Carolina to Mississippi bus services, operated by Greyhound USA, arrive at Jackson, Ms station.

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Map of how to get from South Carolina to Mississippi.
Launch map view
  • Distance: 542 miles
  • Duration: 2 h 31 min

What companies run services between South Carolina, USA and Mississippi, USA?

American Airlines and Delta fly from Rock Hill to Southaven hourly. Alternatively, you can take a bus from Florence to Jackson via Atlanta, Ga in around 13 h 6 min.

Airlines
Delta
Website
delta.com
Flights from Charlotte to Memphis via Atlanta
Ave. Duration
4 h 9 min
When
Every day
Estimated price
$310 - $750
Flights from Charlotte to Gulfport/Biloxi via Atlanta
Ave. Duration
3 h 50 min
When
Every day
Estimated price
$410 - $2,700
Flights from Greenville/Spartanburg to Columbus Golden Triangle Regional via Atlanta
Ave. Duration
4 h 4 min
When
Every day
Estimated price
$200 - $1,100
Flights from Charlotte to Jackson/Vicksburg via Atlanta
Ave. Duration
3 h 48 min
When
Every day
Estimated price
$350 - $750
Flights from Charlotte to Mobile via Atlanta
Ave. Duration
3 h 53 min
When
Every day
Estimated price
$190 - $1,000
American Airlines
Website
aa.com
Flights from Charlotte to Memphis
Ave. Duration
1 h 49 min
When
Every day
Estimated price
$330 - $700
Flights from Charlotte to Gulfport/Biloxi
Ave. Duration
1 h 49 min
When
Every day
Estimated price
$390 - $2,700
Flights from Charlotte to Jackson/Vicksburg
Ave. Duration
1 h 54 min
When
Every day
Estimated price
$300 - $700
Flights from Charlotte to Mobile
Ave. Duration
1 h 51 min
When
Every day
Estimated price
$200 - $1,000
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Florence Amtrak to Selma-Smithfield Amtrak
Ave. Duration
2 h 13 min
Frequency
Once daily
Estimated price
$30 - $75
Website
amtrak.com
Coach Seat
$30 - $50
Flexi Coach Seat
$55 - $85
Business Coach Seat
$50 - $75
Room
$170 - $240
Train from Selma-Smithfield Amtrak to Greensboro Galyon Transportation Center
Ave. Duration
2 h 29 min
Frequency
Once daily
Estimated price
$30 - $70
Website
amtrak.com
Coach Seat
$30 - $45
Flexi Coach Seat
$55 - $80
Business Coach Seat
$45 - $70
Room
$160 - $230
Train from Greensboro Galyon Transportation Center to New Orleans Union Passenger Terminal
Ave. Duration
20 h 10 min
Frequency
Once daily
Estimated price
$110 - $340
Website
amtrak.com
Coach Seat
$110 - $180
Flexi Coach Seat
$210 - $300
Business Coach Seat
$240 - $340
Room
$470 - $650
Train from New Orleans Union Passenger Terminal to Jackson Amtrak
Ave. Duration
3 h 43 min
Frequency
Once daily
Estimated price
$35 - $95
Website
amtrak.com
Coach Seat
$35 - $60
Flexi Coach Seat
$70 - $100
Business Coach Seat
$65 - $95
Room
$190 - $270
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Atlanta, Ga to Jackson, Ms
Ave. Duration
7 h
Frequency
Every 30 minutes
Estimated price
$40 - $100
Website
greyhound.com
Economy
$40 - $65
Flexible
$75 - $100
Bus from Florence, Sc to Savannah, Ga
Ave. Duration
3 h
Frequency
Every 30 minutes
Estimated price
$22 - $55
Website
greyhound.com
Economy
$22 - $35
Flexible
$40 - $55
Bus from Savannah, Ga to Atlanta, Ga
Ave. Duration
4 h 25 min
Frequency
Every 15 minutes
Estimated price
$29 - $70
Website
greyhound.com
Economy
$29 - $50
Flexible
$55 - $70
Bus from Atlanta, Ga to Birmingham, Al
Ave. Duration
2 h 45 min
Frequency
Every 30 minutes
Estimated price
$20 - $50
Website
greyhound.com
Economy
$20 - $35
Flexible
$35 - $50
Bus from Birmingham, Al to Jackson, Ms
Ave. Duration
3 h 45 min
Frequency
Every 30 minutes
Estimated price
$28 - $70
Website
greyhound.com
Economy
$28 - $45
Flexible
$50 - $70

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More Questions & Answers

Mississippi is 1 h behind South Carolina. It is currently 4:05 PM in South Carolina and 3:05 PM in Mississippi.

South Carolina to Mississippi train services, operated by Amtrak, arrive at Jackson Amtrak station.

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Yes, the driving distance between South Carolina to Mississippi is 676 miles. It takes approximately 11 h 9 min to drive from South Carolina to Mississippi.

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American Airlines and Delta offer flights from Charlotte Airport to Memphis Airport.

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Book your South Carolina to Mississippi train tickets online with Rome2rio.

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Book your South Carolina to Mississippi bus tickets online with Greyhound, Greyhound and two other operators.

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There are four+ hotels available in Mississippi. Prices start at $100 USD per night.

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The best way to get from South Carolina to Charlotte Airport is to taxi which takes 35 min and costs .

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