• Our partners include:

  • Greyhound USA
  • VIA Rail
  • Amtrak
  • Acela Express
  • Megabus
  • SuperShuttle
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  • Airbnb
  • Expedia

There are 11 ways to get from South Carolina to Illinois by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly Greenville/Spartanburg to Chicago O'Hare  •  4h 16m

  1. Fly from Greenville/Spartanburg (GSP) to Chicago O'Hare (ORD) GSP - ORD

$182 - $599

Cheapest option

Bus Megabus  •  22h 7m

  1. Take the bus from Florence, SC to Atlanta, Ga Fayetteville
  2. Take the bus from Marta Civic Center Station - Nb to Chicago

$103 - $146

9 alternative options

Fly Charleston to Chicago Midway  •  4h 45m

  1. Fly from Charleston (CHS) to Chicago Midway (MDW) CHS - MDW

$176 - $610

Bus to Charlotte, fly to Chicago Midway  •  5h 15m

  1. Take the bus from White Street Park and Ride to Johnson & Wales Way & 4th St
  2. Fly from Charlotte (CLT) to Chicago Midway (MDW) CLT - MDW

$170 - $455

Fly Columbia to Chicago O'Hare  •  5h 49m

  1. Fly from Columbia (CAE) to Chicago O'Hare (ORD) CAE - ORD

$218 - $558

Bus to Charlotte, fly to Chicago O'Hare  •  6h 43m

  1. Take the bus from White Street Park and Ride to Johnson & Wales Way & 4th St
  2. Fly from Charlotte (CLT) to Chicago O'Hare (ORD) CLT - ORD

$144 - $368

Fly Charleston to Chicago O'Hare  •  6h 31m

  1. Fly from Charleston (CHS) to Chicago O'Hare (ORD) CHS - ORD

$150 - $483

Bus Greyhound USA  •  26h 9m

  1. Take the bus from Florence, Sc to Savannah, Ga
  2. Take the bus from Savannah, Ga to Atlanta, Ga
  3. Take the bus from Atlanta, Ga to Chicago, Il

$124 - $306

Train  •  27h 17m

  1. Take the train from Florence Amtrak Station to Washington Union Station Palmetto / ...
  2. Take the train from Washington Union Station to Chicago Union Station Capitol Limited

$168 - $486

Train via Alexandria Amtrak Station  •  32h 32m

  1. Take the train from Florence Amtrak Station to Alexandria Amtrak Station Palmetto / ...
  2. Take the train from Alexandria Amtrak Station to Chicago Union Station Cardinal

$187 - $523

Drive  •  14h 48m

  1. Drive from Florence to Chicago 881.8 miles

$85 - $130

Questions & Answers

The cheapest way to get from South Carolina to Illinois is to drive which costs $85 - $130 and takes 14h 48m.

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The quickest way to get from South Carolina to Illinois is to fly which costs $180 - $600 and takes 4h 16m.

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No, there is no direct bus from South Carolina to Illinois. However, there are services departing from Florence, Sc and arriving at Loomis & Cermak via Savannah, Ga, Atlanta, Ga and Harrison & Morgan. The journey, including transfers, takes approximately 26h 9m.

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The distance between South Carolina and Illinois is 668 miles. The road distance is 881.8 miles.

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The best way to get from South Carolina to Illinois without a car is to bus which takes 22h 7m and costs $100 - $150.

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It takes approximately 4h 16m to get from South Carolina to Illinois, including transfers.

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South Carolina to Illinois bus services, operated by Greyhound USA, depart from Florence, Sc station.

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The best way to get from South Carolina to Illinois is to fly which takes 4h 16m and costs $180 - $600. Alternatively, you can bus, which costs $100 - $150 and takes 22h 7m, you could also train, which costs $160 - $490 and takes 27h 17m.

Mode details

The quickest flight from Greenville/Spartanburg Airport to Chicago O'Hare Airport is the direct flight which takes 2h 7m.

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South Carolina to Illinois bus services, operated by Greyhound USA, arrive at Chicago, Il station.

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Map of how to get from South Carolina to Illinois.
Launch map view
  • Distance: 668.3 miles
  • Duration: 4h 16m

What companies run services between South Carolina, USA and Illinois, USA?

American Airlines, United Airlines and Delta fly from Greenville to Schaumburg hourly. Alternatively, you can take a bus from Florence to Chicago via Atlanta, Ga, Five Points Station, Civic Center Station, Marta Civic Center Station - Nb, Chicago, and LaSalle/Van Buren in around 22h 7m.

Airlines
American Airlines
Website
aa.com
Flights from Greenville/Spartanburg to Chicago O'Hare
Ave. Duration
2h 14m
When
Every day
Estimated price
$280 - $800
Flights from Greenville/Spartanburg to Chicago O'Hare via Charlotte
Ave. Duration
4h 14m
When
Every day
Estimated price
$280 - $800
Flights from Columbia to Chicago O'Hare via Charlotte
Ave. Duration
4h 34m
When
Every day
Estimated price
$400 - $1,100
Flights from Charlotte to Chicago O'Hare
Ave. Duration
2h 11m
When
Every day
Estimated price
$200 - $600
Flights from Charlotte to Chicago O'Hare via Covington
Ave. Duration
3h 44m
When
Monday to Friday
Estimated price
$200 - $600
Flights from Charlotte to Chicago O'Hare via Indianapolis
Ave. Duration
3h 51m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$200 - $600
Flights from Charlotte to Chicago O'Hare via Wilmington
Ave. Duration
3h 54m
When
Every day
Estimated price
$200 - $600
Flights from Charlotte to Chicago O'Hare via Augusta
Ave. Duration
3h 56m
When
Tuesday and Wednesday
Estimated price
$200 - $600
Flights from Charlotte to Chicago O'Hare via Louisville
Ave. Duration
3h 59m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$200 - $600
Flights from Charleston to Chicago O'Hare
Ave. Duration
2h 37m
When
Every day
Estimated price
$290 - $1,200
Flights from Charleston to Chicago O'Hare via Charlotte
Ave. Duration
4h 20m
When
Monday to Saturday
Estimated price
$290 - $1,200
Flights from Charleston to Chicago O'Hare via Reagan Washington
Ave. Duration
4h 37m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$290 - $1,200
United Airlines
Website
united.com
Flights from Greenville/Spartanburg to Chicago O'Hare
Ave. Duration
2h 14m
When
Every day
Estimated price
$280 - $1,100
Flights from Greenville/Spartanburg to Chicago O'Hare via Washington Dulles
Ave. Duration
4h 22m
When
Monday, Wednesday, Thursday, Friday and Sunday
Estimated price
$280 - $1,100
Flights from Columbia to Chicago O'Hare
Ave. Duration
2h 27m
When
Every day
Estimated price
$320 - $900
Flights from Columbia to Chicago O'Hare via Washington Dulles
Ave. Duration
4h 35m
When
Every day
Estimated price
$320 - $900
Flights from Charlotte to Chicago O'Hare
Ave. Duration
2h 16m
When
Every day
Estimated price
$180 - $550
Flights from Charleston to Chicago O'Hare
Ave. Duration
2h 34m
When
Every day
Estimated price
$300 - $1,100
Flights from Charleston to Chicago O'Hare via Washington Dulles
Ave. Duration
4h 36m
When
Every day
Estimated price
$300 - $1,100
Delta
Website
delta.com
Flights from Greenville/Spartanburg to Chicago O'Hare via Atlanta
Ave. Duration
4h 15m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$260 - $1,300
Flights from Charleston to Chicago Midway via Atlanta
Ave. Duration
4h 46m
When
Every day
Estimated price
$280 - $1,400
Flights from Charlotte to Chicago Midway via Atlanta
Ave. Duration
4h 47m
When
Every day
Estimated price
$210 - $700
Flights from Columbia to Chicago O'Hare via Atlanta
Ave. Duration
4h 50m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$420 - $1,000
Flights from Charleston to Chicago O'Hare via Atlanta
Ave. Duration
4h 37m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$320 - $1,400
Southwest Airlines
Website
southwest.com
Flights from Charleston to Chicago Midway
Ave. Duration
2h 15m
When
Every day
Estimated price
$350 - $1,600
Flights from Charleston to Chicago Midway via Nashville
Ave. Duration
4h 20m
When
Sunday
Estimated price
$350 - $1,600
Flights from Charleston to Chicago Midway via Baltimore
Ave. Duration
4h 38m
When
Every day
Estimated price
$350 - $1,600
Flights from Charlotte to Chicago Midway
Ave. Duration
2h 3m
When
Every day
Estimated price
$310 - $800
Flights from Charlotte to Chicago Midway via Nashville
Ave. Duration
3h 45m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$310 - $800
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from Florence Amtrak Station to Washington Union Station
Ave. Duration
8h 3m
Frequency
Twice daily
Estimated price
$65 - $180
Website
amtrak.com
Coach Seat
$65 - $100
Flexi Coach Seat
$110 - $170
Business Coach Seat
$120 - $180
Room
$280 - $400
Train from Washington Union Station to Chicago Union Station
Ave. Duration
17h 40m
Frequency
Once daily
Estimated price
$100 - $310
Website
amtrak.com
Coach Seat
$100 - $160
Flexi Coach Seat
$190 - $280
Business Coach Seat
$220 - $310
Room
$440 - $600
Train from Florence Amtrak Station to Alexandria Amtrak Station
Ave. Duration
7h 28m
Frequency
Twice daily
Estimated price
$60 - $170
Website
amtrak.com
Coach Seat
$60 - $95
Flexi Coach Seat
$110 - $170
Business Coach Seat
$120 - $170
Room
$280 - $390
Train from Alexandria Amtrak Station to Chicago Union Station
Ave. Duration
23h 41m
Frequency
3 times a week
Estimated price
$120 - $350
Website
amtrak.com
Coach Seat
$120 - $180
Flexi Coach Seat
$210 - $310
Business Coach Seat
$250 - $350
Room
$490 - $700
Bus operators
Charlotte Area Transit System
Phone
+1 704-336-7433
Email
telltransit@charlottenc.gov
Website
charlottenc.gov
Bus from White Street Park and Ride to Johnson & Wales Way & 4th St
Ave. Duration
1h 1m
Frequency
3 times a day
Estimated price
$3 - $5
Schedules at
charlottenc.gov
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Florence, Sc to Savannah, Ga
Ave. Duration
3h
Frequency
5 times a day
Estimated price
$22 - $55
Website
greyhound.com
Economy
$22 - $35
Flexible
$40 - $55
Bus from Savannah, Ga to Atlanta, Ga
Ave. Duration
4h 25m
Frequency
Every 2 hours
Estimated price
$29 - $70
Website
greyhound.com
Economy
$29 - $50
Flexible
$55 - $70
Bus from Atlanta, Ga to Chicago, Il
Ave. Duration
16h 25m
Frequency
4 times a day
Estimated price
$70 - $180
Website
greyhound.com
Economy
$70 - $120
Flexible
$130 - $180

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

More Questions & Answers

Illinois is 1h behind South Carolina. It is currently 8:26 AM in South Carolina and 7:26 AM in Illinois.

Yes, the driving distance between South Carolina to Illinois is 882 miles. It takes approximately 14h 48m to drive from South Carolina to Illinois.

Get driving directions

Delta, United Airlines and American Airlines offer flights from Greenville/Spartanburg Airport to Chicago O'Hare Airport.

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There are four+ hotels available in Illinois. Prices start at $100 USD per night.

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The best way to get from South Carolina to Greenville/Spartanburg Airport is to taxi which takes 18m and costs $35 - $45.

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