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There are 4 ways to get from South Carolina to Gainesville by train, car, plane or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Train, drive  •  7h 20m

  1. Take the train from Florence Amtrak Station to Jacksonville Amtrak Station Silver Meteor
  2. Drive from Jacksonville Amtrak Station to Gainesville

$64 - $160

3 alternative options

Drive  •  6h 22m

  1. Drive from Florence to Gainesville 379 miles

$35 - $55

Fly from Greenville/Spartanburg  •  4h 48m

  1. Fly from Greenville/Spartanburg (GSP) to Gainesville (GNV) GSP - GNV

$278 - $1,344

Bus to Charlotte, fly  •  5h 30m

  1. Take the bus from White Street Park and Ride to Johnson & Wales Way & 4th St
  2. Fly from Charlotte (CLT) to Gainesville (GNV) CLT - GNV

$270 - $1,413

Questions & Answers

The cheapest way to get from South Carolina to Gainesville is to drive which costs $35 - $55 and takes 6h 22m.

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The quickest way to get from South Carolina to Gainesville is to fly which costs $270 - $1,400 and takes 4h 48m.

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The distance between South Carolina and Gainesville is 302 miles. The road distance is 379 miles.

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It takes approximately 7h 20m to get from South Carolina to Gainesville, including transfers.

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There is no direct flight from Greenville/Spartanburg Airport to Gainesville Airport. The quickest flight takes 3h 16m and has one stopover.

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Yes, the driving distance between South Carolina to Gainesville is 379 miles. It takes approximately 6h 22m to drive from South Carolina to Gainesville.

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American Airlines and Delta offer flights from Greenville/Spartanburg Airport to Gainesville Airport.

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There are 52+ hotels available in Gainesville. Prices start at $59 USD per night.

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The best way to get from South Carolina to Greenville/Spartanburg Airport is to taxi which takes 18m and costs $35 - $45.

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Map of how to get from South Carolina to Gainesville.
Launch map view
  • Distance: 301.9 miles
  • Duration: 7h 20m

What companies run services between South Carolina, USA and Gainesville, FL, USA?

Delta, American Airlines and Southwest Airlines fly from Greenville to Gainesville hourly.

Airlines
Delta
Website
delta.com
Flights from Greenville/Spartanburg to Gainesville via Atlanta
Ave. Duration
4h 11m
When
Every day
Estimated price
$240 - $1,300
Flights from Greenville/Spartanburg to Gainesville via Detroit, Atlanta
Ave. Duration
7h 20m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$340 - $1,600
Flights from Charlotte to Gainesville via Atlanta
Ave. Duration
3h 40m
When
Every day
Estimated price
$260 - $1,400
American Airlines
Website
aa.com
Flights from Greenville/Spartanburg to Gainesville via Charlotte
Ave. Duration
3h 52m
When
Every day
Estimated price
$260 - $1,300
Flights from Greenville/Spartanburg to Gainesville via Miami
Ave. Duration
4h 29m
When
Monday, Thursday, Friday and Sunday
Estimated price
$310 - $1,400
Flights from Greenville/Spartanburg to Gainesville via Reagan Washington, Charlotte
Ave. Duration
7h 4m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$330 - $1,500
Flights from Charlotte to Gainesville
Ave. Duration
1h 28m
When
Every day
Estimated price
$260 - $1,400
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from Florence Amtrak Station to Jacksonville Amtrak Station
Ave. Duration
5h 56m
Frequency
Once daily
Estimated price
$55 - $150
Website
amtrak.com
Coach Seat
$55 - $85
Flexi Coach Seat
$100 - $150
Business Coach Seat
$100 - $150
Room
$260 - $360
Bus operators
Charlotte Area Transit System
Phone
+1 704-336-7433
Email
telltransit@charlottenc.gov
Website
charlottenc.gov
Bus from White Street Park and Ride to Johnson & Wales Way & 4th St
Ave. Duration
1h 1m
Frequency
3 times a day
Estimated price
$3 - $5
Schedules at
charlottenc.gov

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