There are 8 ways to get from South Carolina to Florida Panhandle by plane, taxi, car, bus or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly Greenville/Spartanburg to Panama City, taxi  •  4 h 11 min

  1. Fly from Greenville/Spartanburg (GSP) to Panama City (ECP) GSP - ECP
  2. Take a taxi from Panama City to Florida Panhandle

$366 - $1,392

Cheapest option

Bus, drive  •  10 h 5 min

  1. Take the bus from Florence, Sc to Jacksonville, Fl
  2. Take the bus from Jacksonville, Fl to Tallahassee, Fl
  3. Drive from Tallahassee, Fl to Florida Panhandle

$62 - $142

6 alternative options

Fly Charlotte to Panama City, taxi  •  3 h 15 min

  1. Fly from Charlotte (CLT) to Panama City (ECP) CLT - ECP
  2. Take a taxi from Panama City to Florida Panhandle

$428 - $1,443

Fly Charlotte to Tallahassee, drive  •  3 h 14 min

  1. Fly from Charlotte (CLT) to Tallahassee (TLH) CLT - TLH
  2. Drive from Tallahassee to Florida Panhandle

$303 - $1,302

Fly Greenville/Spartanburg to Tallahassee, drive  •  4 h 27 min

  1. Fly from Greenville/Spartanburg (GSP) to Tallahassee (TLH) GSP - TLH
  2. Drive from Tallahassee to Florida Panhandle

$241 - $1,151

Fly Charlotte to Valparaiso, drive  •  4 h

  1. Fly from Charlotte (CLT) to Valparaiso (VPS) CLT - VPS
  2. Drive from Valparaiso to Florida Panhandle

$286 - $1,206

Train, bus, drive  •  10 h 40 min

  1. Take the train from Florence Amtrak to Jacksonville Amtrak
  2. Take the bus from Jacksonville, Fl to Tallahassee, Fl
  3. Drive from Tallahassee, Fl to Florida Panhandle

$103 - $231

Drive  •  8 h 49 min

  1. Drive from Florence to Florida Panhandle 533.5 miles

$50 - $80

Questions & Answers

The distance between South Carolina and Florida Panhandle is 360 miles. The road distance is 533.5 miles.

Get driving directions

It takes approximately 4 h 11 min to get from South Carolina to Florida Panhandle, including transfers.

More details

There is no direct flight from Greenville/Spartanburg Airport to Panama City Airport. The quickest flight takes 3 h 1 min and has one stopover.

Search flights

Yes, the driving distance between South Carolina to Florida Panhandle is 534 miles. It takes approximately 8 h 49 min to drive from South Carolina to Florida Panhandle.

Get driving directions

United Airlines, American Airlines and Delta offer flights from Greenville/Spartanburg Airport to Panama City Airport.

Search flights

The best way to get from South Carolina to Greenville/Spartanburg Airport is to taxi which takes 18 min and costs .

More details

Map of how to get from South Carolina to Florida Panhandle.
Launch map view
  • Distance: 360 miles
  • Duration: 4 h 11 min

What companies run services between South Carolina, USA and Florida Panhandle, FL, USA?

There is no direct connection from Greenville to Florida Panhandle. However, you can take the taxi to Greenville/Spartanburg airport, fly to Panama City, then take the taxi to Florida Panhandle. Alternatively, you can take the taxi to Charlotte airport, fly to Panama City, then take the taxi to Florida Panhandle.

Airlines
Delta
Website
delta.com
Flights from Greenville/Spartanburg to Panama City via Atlanta
Ave. Duration
3 h 48 min
When
Every day
Estimated price
$210 - $1,200
Flights from Charlotte to Panama City via Atlanta
Ave. Duration
3 h 50 min
When
Every day
Estimated price
$230 - $1,200
Flights from Charlotte to Tallahassee via Atlanta
Ave. Duration
3 h 27 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$220 - $1,200
Flights from Greenville/Spartanburg to Tallahassee via Atlanta
Ave. Duration
3 h 35 min
When
Every day
Estimated price
$200 - $1,100
Flights from Charlotte to Valparaiso via Atlanta
Ave. Duration
3 h 43 min
When
Every day
Estimated price
$200 - $1,100
American Airlines
Website
aa.com
Flights from Greenville/Spartanburg to Panama City via Charlotte
Ave. Duration
4 h 13 min
When
Every day
Estimated price
$240 - $1,200
Flights from Charlotte to Panama City
Ave. Duration
1 h 41 min
When
Every day
Estimated price
$240 - $1,300
Flights from Charlotte to Tallahassee
Ave. Duration
1 h 29 min
When
Every day
Estimated price
$230 - $1,200
Flights from Greenville/Spartanburg to Tallahassee via Charlotte
Ave. Duration
4 h 2 min
When
Every day
Estimated price
$220 - $1,100
Flights from Charlotte to Valparaiso
Ave. Duration
1 h 39 min
When
Every day
Estimated price
$220 - $1,100
Southwest Airlines
Website
southwest.com
Flights from Charlotte to Panama City via Nashville
Ave. Duration
3 h 38 min
When
Every day
Estimated price
$300 - $1,300
United Airlines
Website
united.com
Flights from Greenville/Spartanburg to Panama City via Houston
Ave. Duration
5 h 55 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$340 - $1,500
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Florence Amtrak to Jacksonville Amtrak
Ave. Duration
5 h 56 min
Frequency
Once daily
Estimated price
$55 - $150
Website
amtrak.com
Coach Seat
$55 - $85
Flexi Coach Seat
$100 - $150
Business Coach Seat
$100 - $150
Room
$260 - $360
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Florence, Sc to Jacksonville, Fl
Ave. Duration
5 h 30 min
Frequency
Every 30 minutes
Estimated price
$35 - $85
Website
greyhound.com
Economy
$35 - $55
Flexible
$65 - $85
Bus from Jacksonville, Fl to Tallahassee, Fl
Ave. Duration
2 h 40 min
Frequency
Hourly
Estimated price
$21 - $50
Website
greyhound.com
Economy
$21 - $35
Flexible
$35 - $50
Other operators
Taxi from Panama City to Florida Panhandle
Ave. Duration
1 h 2 min
Estimated price
$120 - $150
Red Cabs of Panama City
Phone
+1 850-733-2227
Website
myfloridacabs.com
H2O Shuttle Taxi and Limo
Phone
+1 850-708-2870
Emerald Taxi
Phone
+1 850-792-2546
Website
emeraldtaxiandshuttle.com

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