There are 9 ways to get from South Carolina to Des Moines by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly Charlotte to Des Moines  •  4 h 19 min

  1. Fly from Charlotte (CLT) to Des Moines (DSM) CLT - DSM

$240 - $565

Cheapest option

Bus Megabus  •  29 h 15 min

  1. Take the bus from Florence, SC to Atlanta, Ga
  2. Take the bus from Marta Civic Center Station - Nb to Chicago
  3. Take the bus from Chicago, IL to Des Moines, IA

$146 - $223

7 alternative options

Fly Greenville/Spartanburg to Des Moines  •  6 h 3 min

  1. Fly from Greenville/Spartanburg (GSP) to Des Moines (DSM) GSP - DSM

$228 - $844

Fly Charlotte to Cedar Rapids, bus  •  7 h 14 min

  1. Fly from Charlotte (CLT) to Cedar Rapids (CID) CLT - CID
  2. Take the bus from Cedar Rapids to Des Moines, IA

$318 - $1,143

Fly Greenville/Spartanburg to Cedar Rapids, bus  •  8 h 44 min

  1. Fly from Greenville/Spartanburg (GSP) to Cedar Rapids (CID) GSP - CID
  2. Take the bus from Cedar Rapids to Des Moines, IA

$256 - $1,042

Bus  •  28 h 51 min

  1. Take the bus from Florence, Sc to Savannah, Ga
  2. Take the bus from Savannah, Ga to Atlanta, Ga
  3. Take the bus from Atlanta, Ga to St Louis, Mo
  4. Take the bus from St Louis, Mo to Kansas City, Mo
  5. Take the bus from Kansas City, MO to Des Moines, IA 802 / ...

$176 - $388

Train, bus  •  36 h 22 min

  1. Take the train from Florence Amtrak to Washington Union Station
  2. Take the train from Washington Union Station to Chicago Union Station
  3. Take the train from Chicago Union Station to Ottumwa Amtrak
  4. Take the bus from Ottumwa, IA to Monroe, IA
  5. Take the bus from Monroe, IA to Des Moines, IA

$264 - $688

Train, bus via Alexandria Amtrak  •  41 h 48 min

  1. Take the train from Florence Amtrak to Alexandria Amtrak
  2. Take the train from Alexandria Amtrak to Chicago Union Station
  3. Take the train from Chicago Union Station to Ottumwa Amtrak
  4. Take the bus from Ottumwa, IA to Monroe, IA
  5. Take the bus from Monroe, IA to Des Moines, IA

$283 - $725

Drive  •  19 h 29 min

  1. Drive from Florence to Des Moines 1176.7 miles

$110 - $170

Questions & Answers

No, there is no direct bus from South Carolina to Des Moines. However, there are services departing from Florence, Sc and arriving at Des Moines, IA via Savannah, Ga, Atlanta, Ga, St Louis, Mo and Kansas City, MO. The journey, including transfers, takes approximately 28 h 51 min.

More details

The distance between South Carolina and Des Moines is 908 miles. The road distance is 1176.7 miles.

Get driving directions

The best way to get from South Carolina to Des Moines without a car is to bus which takes 28 h 51 min and costs .

More details

It takes approximately 4 h 19 min to get from South Carolina to Des Moines, including transfers.

More details

South Carolina to Des Moines bus services, operated by Greyhound USA, depart from Florence, Sc station.

More details

The best way to get from South Carolina to Des Moines is to fly which takes 4 h 19 min and costs . Alternatively, you can bus, which costs and takes 28 h 51 min.

Mode details

The quickest flight from Charlotte Airport to Des Moines Airport is the direct flight which takes 2 h 28 min.

Search flights

South Carolina to Des Moines bus services, operated by Jefferson Lines, arrive at Des Moines, IA station.

More details

Des Moines is 1 h behind South Carolina. It is currently 5:05 PM in South Carolina and 4:05 PM in Des Moines.

Yes, the driving distance between South Carolina to Des Moines is 1177 miles. It takes approximately 19 h 29 min to drive from South Carolina to Des Moines.

Get driving directions

Map of how to get from South Carolina to Des Moines.
Launch map view
  • Distance: 908.1 miles
  • Duration: 4 h 19 min

What companies run services between South Carolina, USA and Des Moines, IA, USA?

American Airlines, United Airlines and Delta fly from Rock Hill to Des Moines hourly. Alternatively, you can take a bus from Florence to Des Moines via Savannah, Ga, Atlanta, Ga, St Louis, Mo, Kansas City, Mo, and Kansas City, MO in around 28 h 51 min.

Airlines
American Airlines
Website
aa.com
Flights from Charlotte to Des Moines
Ave. Duration
2 h 31 min
When
Every day
Estimated price
$290 - $700
Flights from Charlotte to Des Moines via Chicago O'Hare
Ave. Duration
5 h 4 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$290 - $700
Flights from Greenville/Spartanburg to Des Moines via Charlotte
Ave. Duration
5 h 1 min
When
Every day
Estimated price
$190 - $900
Flights from Greenville/Spartanburg to Des Moines via Chicago O'Hare
Ave. Duration
4 h 45 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$190 - $900
Flights from Greenville/Spartanburg to Des Moines via Philadelphia
Ave. Duration
5 h 47 min
When
Every day
Estimated price
$230 - $950
Flights from Greenville/Spartanburg to Des Moines via Reagan Washington
Ave. Duration
6 h 22 min
When
Every day
Estimated price
$220 - $950
Flights from Greenville/Spartanburg to Des Moines via Dallas/Ft.Worth
Ave. Duration
5 h 53 min
When
Every day
Estimated price
$230 - $950
Flights from Charlotte to Cedar Rapids
Ave. Duration
2 h 18 min
When
Every day
Estimated price
$210 - $1,000
Flights from Charlotte to Cedar Rapids via Chicago O'Hare
Ave. Duration
4 h 17 min
When
Every day
Estimated price
$220 - $1,000
Flights from Greenville/Spartanburg to Cedar Rapids via Chicago O'Hare
Ave. Duration
4 h 40 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$200 - $950
Flights from Greenville/Spartanburg to Cedar Rapids via Charlotte
Ave. Duration
5 h
When
Every day
Estimated price
$210 - $950
Flights from Greenville/Spartanburg to Cedar Rapids via Dallas/Ft.Worth
Ave. Duration
6 h 26 min
When
Every day
Estimated price
$270 - $1,100
Delta
Website
delta.com
Flights from Charlotte to Des Moines via Detroit
Ave. Duration
4 h 49 min
When
Every day
Estimated price
$200 - $950
Flights from Charlotte to Des Moines via Atlanta
Ave. Duration
4 h 39 min
When
Sunday
Estimated price
$190 - $950
Flights from Charlotte to Des Moines via Minneapolis
Ave. Duration
4 h 53 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$210 - $1,000
Flights from Greenville/Spartanburg to Des Moines via Atlanta
Ave. Duration
4 h 43 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$180 - $900
Flights from Greenville/Spartanburg to Des Moines via Detroit
Ave. Duration
5 h 38 min
When
Every day
Estimated price
$190 - $900
Flights from Greenville/Spartanburg to Des Moines via New York La Guardia
Ave. Duration
8 h 8 min
When
Monday to Friday
Estimated price
$230 - $1,000
Flights from Charlotte to Cedar Rapids via Atlanta
Ave. Duration
4 h 35 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$210 - $1,100
Flights from Charlotte to Cedar Rapids via Minneapolis
Ave. Duration
5 h 6 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$230 - $1,100
Flights from Greenville/Spartanburg to Cedar Rapids via Atlanta
Ave. Duration
4 h 46 min
When
Every day
Estimated price
$190 - $950
Flights from Greenville/Spartanburg to Cedar Rapids via Detroit
Ave. Duration
5 h 1 min
When
Every day
Estimated price
$200 - $1,000
United Airlines
Website
united.com
Flights from Charlotte to Des Moines via Chicago O'Hare
Ave. Duration
4 h 48 min
When
Every day
Estimated price
$330 - $800
Flights from Greenville/Spartanburg to Des Moines via Chicago O'Hare
Ave. Duration
5 h 13 min
When
Every day
Estimated price
$200 - $950
Flights from Greenville/Spartanburg to Des Moines via Houston
Ave. Duration
5 h 43 min
When
Every day
Estimated price
$250 - $1,100
Flights from Charlotte to Cedar Rapids via Chicago O'Hare
Ave. Duration
4 h 17 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$230 - $1,100
Flights from Greenville/Spartanburg to Cedar Rapids via Chicago O'Hare
Ave. Duration
5 h 26 min
When
Every day
Estimated price
$210 - $1,000
Frontier Airlines
Website
flyfrontier.com
Flights from Greenville/Spartanburg to Des Moines via Denver
Ave. Duration
7 h 28 min
When
Wednesday and Saturday
Estimated price
$190 - $800
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Florence Amtrak to Washington Union Station
Ave. Duration
8 h 3 min
Frequency
Twice daily
Estimated price
$65 - $180
Website
amtrak.com
Coach Seat
$65 - $100
Flexi Coach Seat
$110 - $170
Business Coach Seat
$120 - $180
Room
$280 - $400
Train from Washington Union Station to Chicago Union Station
Ave. Duration
17 h 40 min
Frequency
Once daily
Estimated price
$100 - $310
Website
amtrak.com
Coach Seat
$100 - $160
Flexi Coach Seat
$190 - $280
Business Coach Seat
$220 - $310
Room
$440 - $600
Train from Chicago Union Station to Ottumwa Amtrak
Ave. Duration
4 h 53 min
Frequency
Once daily
Estimated price
$50 - $130
Website
amtrak.com
Coach Seat
$50 - $75
Flexi Coach Seat
$90 - $130
Business Coach Seat
$90 - $130
Room
$230 - $320
Train from Florence Amtrak to Alexandria Amtrak
Ave. Duration
7 h 28 min
Frequency
Twice daily
Estimated price
$60 - $170
Website
amtrak.com
Coach Seat
$60 - $95
Flexi Coach Seat
$110 - $170
Business Coach Seat
$120 - $170
Room
$280 - $390
Train from Alexandria Amtrak to Chicago Union Station
Ave. Duration
23 h 41 min
Frequency
4 times a week
Estimated price
$120 - $350
Website
amtrak.com
Coach Seat
$120 - $180
Flexi Coach Seat
$210 - $310
Business Coach Seat
$250 - $350
Room
$490 - $700
Bus operators
Burlington Trailways
Website
burlingtontrailways.com
Bus from Cedar Rapids to Des Moines, IA
Ave. Duration
3 h 20 min
Frequency
Once daily
Estimated price
$30 - $50
Schedules at
burlingtontrailways.com
Book at
burlingtontrailways.com
Bus from Chicago, IL to Des Moines, IA
Ave. Duration
6 h 50 min
Frequency
Hourly
Estimated price
$45 - $80
Schedules at
burlingtontrailways.com
Book at
burlingtontrailways.com
Bus from Ottumwa, IA to Monroe, IA
Ave. Duration
1 h
Frequency
Once daily
Estimated price
$25 - $40
Schedules at
burlingtontrailways.com
Book at
burlingtontrailways.com
Bus from Monroe, IA to Des Moines, IA
Ave. Duration
40 min
Frequency
Once daily
Estimated price
$23 - $35
Schedules at
burlingtontrailways.com
Book at
burlingtontrailways.com
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Florence, Sc to Savannah, Ga
Ave. Duration
3 h
Frequency
Every 30 minutes
Estimated price
$22 - $55
Website
greyhound.com
Economy
$22 - $35
Flexible
$40 - $55
Bus from Savannah, Ga to Atlanta, Ga
Ave. Duration
4 h 25 min
Frequency
Every 15 minutes
Estimated price
$29 - $70
Website
greyhound.com
Economy
$29 - $50
Flexible
$55 - $70
Bus from Atlanta, Ga to St Louis, Mo
Ave. Duration
12 h 50 min
Frequency
Hourly
Estimated price
$55 - $140
Website
greyhound.com
Economy
$55 - $90
Flexible
$100 - $140
Bus from St Louis, Mo to Kansas City, Mo
Ave. Duration
4 h 25 min
Frequency
Hourly
Estimated price
$29 - $70
Website
greyhound.com
Economy
$29 - $45
Flexible
$50 - $70
Jefferson Lines
Phone
800-451-5333
Email
info@jeffersonlines.com
Website
jeffersonlines.com
Bus from Kansas City, MO to Des Moines, IA
Ave. Duration
2 h 55 min
Frequency
Hourly
Estimated price
$40 - $55
Book at
jeffersonlines.com
Megabus

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More Questions & Answers

American Airlines, United Airlines and Delta offer flights from Charlotte Airport to Des Moines Airport.

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There are 106+ hotels available in Des Moines. Prices start at $75 USD per night.

More details

The best way to get from South Carolina to Charlotte Airport is to taxi which takes 35 min and costs .

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