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There are 7 ways to get from South Carolina to Des Moines by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly from Greenville/Spartanburg  •  6h 7m

  1. Fly from Greenville/Spartanburg (GSP) to Des Moines (DSM) GSP - DSM

$217 - $944

Cheapest option

Bus via St Louis, MO  •  32h 17m

  1. Take the bus from Florence, SC to Atlanta, Ga
  2. Take the bus from Atlanta, Ga to St Louis, Mo
  3. Take the bus from St Louis, MO to Mt. Pleasant, IA
  4. Take the bus from Mt. Pleasant, IL to Des Moines, IA

$164 - $342

5 alternative options

Bus to Charlotte, fly  •  6h 45m

  1. Take the bus from White Street Park and Ride to Johnson & Wales Way & 4th St
  2. Fly from Charlotte (CLT) to Des Moines (DSM) CLT - DSM

$169 - $483

Bus  •  31h 41m

  1. Take the bus from Florence, Sc to Savannah, Ga
  2. Take the bus from Savannah, Ga to Atlanta, Ga
  3. Take the bus from Marta Civic Center Station - Nb to Chicago
  4. Take the bus from Chicago, IL to Des Moines, IA

Train, bus  •  35h 16m

  1. Take the train from Florence Amtrak Station to Washington Union Station
  2. Take the train from Washington Union Station to Chicago Union Station
  3. Take the train from Chicago Union Station to Ottumwa Amtrak Station
  4. Take the bus from Ottumwa, IA to Des Moines, IA

$239 - $648

Train, bus via Alexandria Amtrak Station  •  40h 42m

  1. Take the train from Florence Amtrak Station to Alexandria Amtrak Station
  2. Take the train from Alexandria Amtrak Station to Chicago Union Station
  3. Take the train from Chicago Union Station to Ottumwa Amtrak Station
  4. Take the bus from Ottumwa, IA to Des Moines, IA

$258 - $685

Drive  •  19h 29m

  1. Drive from Florence to Des Moines 1176.7 miles

$110 - $170

Questions & Answers

The cheapest way to get from South Carolina to Des Moines is to drive which costs $110 - $170 and takes 19h 29m.

More details

The quickest way to get from South Carolina to Des Moines is to fly which costs $210 - $950 and takes 6h 7m.

More details

No, there is no direct bus from South Carolina to Des Moines. However, there are services departing from Florence, SC and arriving at Des Moines, IA via Atlanta, Ga, 20Th Street @ Cass Sb, St Louis, MO and Mt. Pleasant, IL. The journey, including transfers, takes approximately 32h 17m.

More details

The distance between South Carolina and Des Moines is 908 miles. The road distance is 1176.7 miles.

Get driving directions

The best way to get from South Carolina to Des Moines without a car is to bus which takes 31h 41m and costs .

More details

It takes approximately 6h 7m to get from South Carolina to Des Moines, including transfers.

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South Carolina to Des Moines bus services, operated by South Eastern Stages, depart from Florence, SC station.

More details

The best way to get from South Carolina to Des Moines is to fly which takes 6h 7m and costs $210 - $950. Alternatively, you can bus, which costs and takes 31h 41m.

Mode details

There is no direct flight from Greenville/Spartanburg Airport to Des Moines Airport. The quickest flight takes 4h 33m and has one stopover.

Search flights

South Carolina to Des Moines bus services, operated by Burlington Trailways, arrive at Des Moines, IA station.

More details

Map of how to get from South Carolina to Des Moines.
Launch map view
  • Distance: 908.1 miles
  • Duration: 6h 7m

What companies run services between South Carolina, USA and Des Moines, IA, USA?

Delta, United Airlines and two other airlines fly from Greenville to Des Moines hourly. Alternatively, you can take a bus from Florence to Des Moines via Savannah, Ga, Atlanta, Ga, Five Points Station, Civic Center Station, Marta Civic Center Station - Nb, and Chicago, IL in around 31h 41m.

Airlines
American Airlines
Website
aa.com
Flights from Greenville/Spartanburg to Des Moines via Charlotte
Ave. Duration
5h 10m
When
Every day
Estimated price
$190 - $900
Flights from Greenville/Spartanburg to Des Moines via Chicago O'Hare
Ave. Duration
5h 46m
When
Every day
Estimated price
$190 - $900
Flights from Greenville/Spartanburg to Des Moines via Reagan Washington
Ave. Duration
6h 48m
When
Every day
Estimated price
$220 - $950
Flights from Greenville/Spartanburg to Des Moines via Philadelphia
Ave. Duration
6h 4m
When
Every day
Estimated price
$230 - $950
Flights from Greenville/Spartanburg to Des Moines via Dallas/Ft.Worth
Ave. Duration
7h 34m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$230 - $950
Flights from Greenville/Spartanburg to Des Moines via Charlotte, Chicago O'Hare
Ave. Duration
6h 24m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$200 - $900
Flights from Charlotte to Des Moines
Ave. Duration
2h 43m
When
Every day
Estimated price
$290 - $700
Flights from Charlotte to Des Moines via Chicago O'Hare
Ave. Duration
4h 53m
When
Every day
Estimated price
$290 - $700
Delta
Website
delta.com
Flights from Greenville/Spartanburg to Des Moines via Atlanta
Ave. Duration
4h 41m
When
Every day
Estimated price
$180 - $900
Flights from Greenville/Spartanburg to Des Moines via Detroit
Ave. Duration
5h 56m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$190 - $900
Flights from Greenville/Spartanburg to Des Moines via New York La Guardia
Ave. Duration
9h 1m
When
Monday to Friday
Estimated price
$230 - $1,000
Flights from Charlotte to Des Moines via Detroit
Ave. Duration
4h 50m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$200 - $950
Flights from Charlotte to Des Moines via Atlanta
Ave. Duration
5h 13m
When
Every day
Estimated price
$190 - $950
United Airlines
Website
united.com
Flights from Greenville/Spartanburg to Des Moines via Chicago O'Hare
Ave. Duration
5h 9m
When
Every day
Estimated price
$200 - $950
Flights from Greenville/Spartanburg to Des Moines via Houston
Ave. Duration
6h 4m
When
Monday to Friday
Estimated price
$250 - $1,100
Flights from Charlotte to Des Moines via Chicago O'Hare
Ave. Duration
4h 45m
When
Every day
Estimated price
$330 - $800
Southwest Airlines
Website
southwest.com
Flights from Greenville/Spartanburg to Des Moines via Atlanta, St. Louis
Ave. Duration
6h 17m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$210 - $850
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from Florence Amtrak Station to Washington Union Station
Ave. Duration
8h 3m
Frequency
Twice daily
Estimated price
$65 - $180
Website
amtrak.com
Coach Seat
$65 - $100
Flexi Coach Seat
$110 - $170
Business Coach Seat
$120 - $180
Room
$280 - $400
Train from Washington Union Station to Chicago Union Station
Ave. Duration
17h 40m
Frequency
Once daily
Estimated price
$100 - $310
Website
amtrak.com
Coach Seat
$100 - $160
Flexi Coach Seat
$190 - $280
Business Coach Seat
$220 - $310
Room
$440 - $600
Train from Chicago Union Station to Ottumwa Amtrak Station
Ave. Duration
4h 53m
Frequency
Twice daily
Estimated price
$50 - $130
Website
amtrak.com
Coach Seat
$50 - $75
Flexi Coach Seat
$90 - $130
Business Coach Seat
$90 - $130
Room
$230 - $320
Train from Florence Amtrak Station to Alexandria Amtrak Station
Ave. Duration
7h 28m
Frequency
Twice daily
Estimated price
$60 - $170
Website
amtrak.com
Coach Seat
$60 - $95
Flexi Coach Seat
$110 - $170
Business Coach Seat
$120 - $170
Room
$280 - $390
Train from Alexandria Amtrak Station to Chicago Union Station
Ave. Duration
23h 41m
Frequency
3 times a week
Estimated price
$120 - $350
Website
amtrak.com
Coach Seat
$120 - $180
Flexi Coach Seat
$210 - $310
Business Coach Seat
$250 - $350
Room
$490 - $700
Bus operators
Charlotte Area Transit System
Phone
+1 704-336-7433
Email
telltransit@charlottenc.gov
Website
charlottenc.gov
Bus from White Street Park and Ride to Johnson & Wales Way & 4th St
Ave. Duration
1h 1m
Frequency
3 times a day
Estimated price
$3 - $5
Schedules at
charlottenc.gov
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Florence, Sc to Savannah, Ga
Ave. Duration
3h
Frequency
5 times a day
Estimated price
$22 - $55
Website
greyhound.com
Economy
$22 - $35
Flexible
$40 - $55
Bus from Savannah, Ga to Atlanta, Ga
Ave. Duration
4h 25m
Frequency
Every 2 hours
Estimated price
$29 - $70
Website
greyhound.com
Economy
$29 - $50
Flexible
$55 - $70
Bus from Atlanta, Ga to St Louis, Mo
Ave. Duration
12h 50m
Frequency
3 times a day
Estimated price
$55 - $140
Website
greyhound.com
Economy
$55 - $90
Flexible
$100 - $140
Windstar
Phone
+1 888-494-6378
Email
sara@gowindstar.com
Website
gowindstar.com
Bus from Chicago, IL to Des Moines, IA
Ave. Duration
6h 40m
Frequency
Once daily
Schedules at
gowindstar.com
Burlington Trailways
Website
burlingtontrailways.com
Bus from St Louis, MO to Mt. Pleasant, IA
Ave. Duration
7h 40m
Frequency
Once daily
Estimated price
$40 - $100
Schedules at
burlingtontrailways.com
Book at
burlingtontrailways.com
Bus from Mt. Pleasant, IL to Des Moines, IA
Ave. Duration
2h 40m
Frequency
Once daily
Estimated price
$29 - $45
Schedules at
burlingtontrailways.com
Book at
burlingtontrailways.com
Bus from Ottumwa, IA to Des Moines, IA
Ave. Duration
1h 40m
Frequency
Once daily
Estimated price
$23 - $35
Schedules at
burlingtontrailways.com
Book at
burlingtontrailways.com

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More Questions & Answers

Des Moines is 1h behind South Carolina. It is currently 3:13 PM in South Carolina and 2:13 PM in Des Moines.

Yes, the driving distance between South Carolina to Des Moines is 1177 miles. It takes approximately 19h 29m to drive from South Carolina to Des Moines.

Get driving directions

Southwest Airlines, United Airlines, Delta and American Airlines offer flights from Greenville/Spartanburg Airport to Des Moines Airport.

Search flights

There are 108+ hotels available in Des Moines. Prices start at $69 USD per night.

More details

The best way to get from South Carolina to Greenville/Spartanburg Airport is to taxi which takes 18m and costs $35 - $45.

More details