There are 8 ways to get from South Carolina to Buffalo–Depew Station by plane, train, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly Charlotte to Buffalo  •  3 h 52 min

  1. Fly from Charlotte (CLT) to Buffalo (BUF) CLT - BUF

$210 - $695

Cheapest option

Bus Megabus  •  25 h 31 min

  1. Take the bus from Florence, Sc to Fayetteville, Nc
  2. Take the bus from Fayetteville, NC to Washington
  3. Take the bus from Washington to Buffalo

$96 - $174

6 alternative options

Fly Charlotte to Rochester, train  •  5 h 16 min

  1. Fly from Charlotte (CLT) to Rochester (ROC) CLT - ROC
  2. Take the train from Rochester to Buffalo

$233 - $814

Fly Charlotte to Toronto, train  •  8 h 36 min

  1. Fly from Charlotte (CLT) to Toronto (YYZ) CLT - YYZ
  2. Take the train from Toronto to Buffalo

$291 - $993

Fly Charleston to Buffalo  •  7 h 25 min

  1. Fly from Charleston (CHS) to Buffalo (BUF) CHS - BUF

$266 - $558

Train  •  21 h 8 min

  1. Take the train from Florence Amtrak to New York Penn Station Palmetto / ...
  2. Take the train from New York to Buffalo VIA Rail / ...

$152 - $453

Bus via New York, NY - Port Authority  •  24 h 6 min

  1. Take the bus from Florence, Sc to New York, Ny 1008
  2. Take the bus from New York, NY - Port Authority to Buffalo, NY Nyc / ...

$107 - $259

Drive  •  13 h 35 min

  1. Drive from Florence to Buffalo–Depew Station 773 miles

$75 - $110

Questions & Answers

No, there is no direct bus from South Carolina to Buffalo–Depew Station. However, there are services departing from Florence, Sc and arriving at Walden Ave & 2929 Walden via New York, NY - Port Authority, Ellicott St & North Division St and Galleria Drway & Green Parking Entrance. The journey, including transfers, takes approximately 24 h 6 min.

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No, there is no direct train from South Carolina to Buffalo–Depew Station. However, there are services departing from Florence Amtrak and arriving at Buffalo via New York. The journey, including transfers, takes approximately 21 h 8 min.

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The distance between South Carolina and Buffalo–Depew Station is 647 miles. The road distance is 773 miles.

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The best way to get from South Carolina to Buffalo–Depew Station without a car is to train which takes 21 h 8 min and costs .

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It takes approximately 3 h 52 min to get from South Carolina to Buffalo–Depew Station, including transfers.

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South Carolina to Buffalo–Depew Station bus services, operated by Greyhound USA, depart from Florence, Sc station.

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South Carolina to Buffalo–Depew Station train services, operated by Amtrak, depart from Florence Amtrak station.

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The best way to get from South Carolina to Buffalo–Depew Station is to fly which takes 3 h 52 min and costs . Alternatively, you can train, which costs and takes 21 h 8 min, you could also bus, which costs and takes 24 h 6 min.

Mode details

The quickest flight from Charlotte Airport to Buffalo Airport is the direct flight which takes 1 h 33 min.

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South Carolina to Buffalo–Depew Station bus services, operated by Trailways New York, arrive at Buffalo, NY station.

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Map of how to get from South Carolina to Buffalo–Depew Station.
Launch map view
  • Distance: 647.4 miles
  • Duration: 3 h 52 min

What companies run services between South Carolina, USA and Buffalo–Depew Station, NY, USA?

American Airlines, Southwest Airlines and United Airlines fly from Rock Hill to Buffalo–Depew Station every 3 hours. Alternatively, you can take a train from Florence to Buffalo–Depew Station via New York Penn Station and New York in around 21 h 8 min.

Airlines
American Airlines
Website
aa.com
Flights from Charlotte to Buffalo
Ave. Duration
1 h 42 min
When
Every day
Estimated price
$270 - $1,200
Flights from Charlotte to Buffalo via Reagan Washington
Ave. Duration
3 h 44 min
When
Monday to Friday
Estimated price
$270 - $1,200
Flights from Charlotte to Buffalo via Philadelphia
Ave. Duration
4 h 2 min
When
Monday
Estimated price
$270 - $1,200
Flights from Charlotte to Rochester
Ave. Duration
1 h 48 min
When
Every day
Estimated price
$200 - $1,300
Flights from Charlotte to Rochester via Reagan Washington
Ave. Duration
3 h 51 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$200 - $1,300
Flights from Charlotte to Toronto
Ave. Duration
1 h 59 min
When
Every day
Estimated price
$330 - $1,600
Flights from Charlotte to Toronto via Philadelphia
Ave. Duration
4 h 30 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$330 - $1,600
Flights from Charleston to Buffalo via Reagan Washington
Ave. Duration
4 h 6 min
When
Every day
Estimated price
$500 - $1,300
Flights from Charleston to Buffalo via Philadelphia
Ave. Duration
4 h 13 min
When
Every day
Estimated price
$500 - $1,300
Flights from Charleston to Buffalo via Charlotte
Ave. Duration
4 h 40 min
When
Every day
Estimated price
$500 - $1,300
United Airlines
Website
united.com
Flights from Charlotte to Buffalo via Washington Dulles
Ave. Duration
3 h 47 min
When
Every day
Estimated price
$260 - $1,400
Flights from Charlotte to Rochester via Washington Dulles
Ave. Duration
3 h 49 min
When
Every day
Estimated price
$220 - $1,100
Flights from Charlotte to Rochester via Newark
Ave. Duration
4 h 9 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$220 - $1,100
Flights from Charlotte to Toronto
Ave. Duration
1 h 57 min
When
Every day
Estimated price
$500 - $2,300
Flights from Charlotte to Toronto via Washington Dulles
Ave. Duration
3 h 51 min
When
Every day
Estimated price
$320 - $1,800
Flights from Charlotte to Toronto via Chicago O'Hare
Ave. Duration
4 h 31 min
When
Monday, Wednesday, Thursday, Friday and Saturday
Estimated price
$320 - $1,800
Flights from Charleston to Buffalo via Washington Dulles
Ave. Duration
3 h 42 min
When
Every day
Estimated price
$600 - $1,200
Flights from Charleston to Buffalo via Newark
Ave. Duration
4 h 41 min
When
Every day
Estimated price
$600 - $1,200
Southwest Airlines
Website
southwest.com
Flights from Charlotte to Buffalo via Baltimore
Ave. Duration
3 h 39 min
When
Every day
Estimated price
$310 - $1,200
Flights from Charlotte to Rochester via Baltimore
Ave. Duration
3 h 45 min
When
Saturday and Sunday
Estimated price
$210 - $1,300
Flights from Charleston to Buffalo via Baltimore
Ave. Duration
3 h 50 min
When
Every day
Estimated price
$600 - $1,300
Delta
Website
delta.com
Flights from Charlotte to Rochester via Detroit
Ave. Duration
3 h 53 min
When
Every day
Estimated price
$170 - $1,100
Flights from Charlotte to Toronto via Detroit
Ave. Duration
4 h 12 min
When
Every day
Estimated price
$300 - $1,400
Flights from Charlotte to Toronto via Atlanta
Ave. Duration
4 h 30 min
When
Every day
Estimated price
$300 - $1,400
Flights from Charleston to Buffalo via Atlanta
Ave. Duration
4 h 29 min
When
Every day
Estimated price
$470 - $1,200
Flights from Charleston to Buffalo via New York JFK
Ave. Duration
4 h 22 min
When
Monday, Tuesday, Thursday, Friday and Saturday
Estimated price
$470 - $1,200
Flights from Charleston to Buffalo via Detroit
Ave. Duration
4 h 32 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$470 - $1,200
Air Canada
Website
aircanada.com
Flights from Charlotte to Toronto
Ave. Duration
1 h 57 min
When
Every day
Estimated price
$500 - $2,300
JetBlue Airways
Website
jetblue.com
Flights from Charleston to Buffalo via New York JFK
Ave. Duration
4 h 23 min
When
Every day
Estimated price
$650 - $1,500
Train operators
VIA Rail
Phone
+1 1 888 842-7245
Website
viarail.ca
Train from Rochester to Buffalo
Ave. Duration
1 h 9 min
Frequency
Every 3 hours
Estimated price
$24 - $70
Website
viarail.ca
Escape
$24 - $35
Economy
$30 - $45
Economy Plus
$45 - $70
Business
$40 - $60
Business Plus/Sleeper
$75 - $110
Train from Toronto to Buffalo
Ave. Duration
4 h 39 min
Frequency
Every 3 hours
Estimated price
$29 - $90
Website
viarail.ca
Escape
$29 - $45
Economy
$40 - $55
Economy Plus
$60 - $90
Business
$55 - $80
Business Plus/Sleeper
$100 - $150
Train from New York to Buffalo
Ave. Duration
7 h 56 min
Frequency
Every 3 hours
Estimated price
$60 - $200
Website
viarail.ca
Escape
$60 - $85
Economy
$100 - $140
Economy Plus
$140 - $200
Business
$150 - $210
Business Plus/Sleeper
$260 - $370
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Rochester Amtrak to Buffalo Depew Station Amtrak
Ave. Duration
1 h
Frequency
5 times a day
Estimated price
$25 - $50
Website
amtrak.com
Coach Seat
$25 - $40
Flexi Coach Seat
$45 - $65
Business Coach Seat
$35 - $50
Room
$140 - $200
Train from Florence Amtrak to New York Penn Station
Ave. Duration
12 h 17 min
Frequency
Twice daily
Estimated price
$90 - $260
Website
amtrak.com
Coach Seat
$90 - $140
Flexi Coach Seat
$160 - $230
Business Coach Seat
$180 - $260
Room
$380 - $550
Train from New York Penn Station to Buffalo Depew Station Amtrak
Ave. Duration
7 h 42 min
Frequency
3 times a day
Estimated price
$65 - $190
Website
amtrak.com
Coach Seat
$65 - $100
Flexi Coach Seat
$120 - $180
Business Coach Seat
$130 - $190
Room
$290 - $410
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Florence, Sc to New York, Ny
Ave. Duration
15 h 10 min
Frequency
Hourly
Estimated price
$60 - $160
Website
greyhound.com
Economy
$60 - $100
Flexible
$120 - $160
Bus from New York, Ny to Buffalo, Ny
Ave. Duration
8 h 45 min
Frequency
Every 20 minutes
Estimated price
$40 - $100
Website
greyhound.com
Economy
$40 - $65
Flexible
$75 - $100
Bus from Florence, Sc to Fayetteville, Nc
Ave. Duration
1 h 30 min
Frequency
Hourly
Estimated price
$14 - $35
Website
greyhound.com
Economy
$14 - $22
Flexible
$26 - $35
Trailways New York
Phone
(800) 858-8555
Website
trailwaysny.com
Bus from New York, NY - Port Authority to Buffalo, NY
Ave. Duration
7 h
Frequency
Hourly
Estimated price
$50 - $100
Book at
trailwaysny.com
Megabus
Phone
877-462-6342
Website
us.megabus.com
Bus from Fayetteville, NC to Washington
Ave. Duration
7 h 45 min
Frequency
Twice daily
Estimated price
$30 - $50
Book at
megabus.com
Bus from Washington to Buffalo
Ave. Duration
11 h 55 min
Frequency
Once daily
Estimated price
$45 - $85
Book at
megabus.com

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More Questions & Answers

South Carolina to Buffalo–Depew Station train services, operated by VIA Rail, arrive at Buffalo station.

More details

Yes, the driving distance between South Carolina to Buffalo–Depew Station is 773 miles. It takes approximately 13 h 35 min to drive from South Carolina to Buffalo–Depew Station.

Get driving directions

American Airlines, United Airlines and Southwest Airlines offer flights from Charlotte Airport to Buffalo Airport.

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There are 130+ hotels available in Buffalo–Depew Station. Prices start at $65 USD per night.

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The best way to get from South Carolina to Charlotte Airport is to taxi which takes 35 min and costs .

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