There are 6 ways to get from South Carolina to Buffalo by plane, train, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly from Charlotte  •  2 h 52 min

  1. Fly from Charlotte (CLT) to Buffalo (BUF) CLT - BUF

$210 - $710

Cheapest option

Bus via Richmond, Va  •  21 h 52 min

  1. Take the bus from Florence, Sc to Fayetteville, Nc
  2. Take the bus from Fayetteville, Nc to Richmond, Va
  3. Take the bus from Richmond, Va to Washington, Dc
  4. Take the bus from Washington to Buffalo

$102 - $223

4 alternative options

Fly from Charleston  •  6 h 25 min

  1. Fly from Charleston (CHS) to Buffalo (BUF) CHS - BUF

$266 - $573

Train  •  21 h 21 min

  1. Take the train from Florence Amtrak to New York Penn Station Palmetto / ...
  2. Take the train from New York to Buffalo VIA Rail / ...

$152 - $463

Bus  •  23 h 33 min

  1. Take the bus from Florence, Sc to Fayetteville, Nc
  2. Take the bus from Fayetteville, NC to Arlington, VA
  3. Take the bus from Washington to Buffalo

Drive  •  13 h 31 min

  1. Drive from Florence to Buffalo 769 miles

$75 - $110

Questions & Answers

No, there is no direct bus from South Carolina to Buffalo. However, there are services departing from Florence, Sc and arriving at Buffalo via Fayetteville, Nc, Richmond, Va and Washington. The journey, including transfers, takes approximately 21 h 52 min.

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No, there is no direct train from South Carolina to Buffalo. However, there are services departing from Florence Amtrak and arriving at Buffalo via New York. The journey, including transfers, takes approximately 21 h 21 min.

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The distance between South Carolina and Buffalo is 645 miles. The road distance is 769 miles.

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The best way to get from South Carolina to Buffalo without a car is to train which takes 21 h 21 min and costs .

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It takes approximately 2 h 52 min to get from South Carolina to Buffalo, including transfers.

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South Carolina to Buffalo bus services, operated by Greyhound USA, depart from Florence, Sc station.

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South Carolina to Buffalo train services, operated by Amtrak, depart from Florence Amtrak station.

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The best way to get from South Carolina to Buffalo is to fly which takes 2 h 52 min and costs . Alternatively, you can train, which costs and takes 21 h 21 min, you could also bus, which costs and takes 21 h 52 min.

Mode details

The quickest flight from Charlotte Airport to Buffalo Airport is the direct flight which takes 1 h 33 min.

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South Carolina to Buffalo bus services, operated by Megabus, arrive at Buffalo station.

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Map of how to get from South Carolina to Buffalo.
Launch map view
  • Distance: 644.9 miles
  • Duration: 2 h 52 min

What companies run services between South Carolina, USA and Buffalo, NY, USA?

American Airlines, Southwest Airlines and United Airlines fly from Rock Hill to Buffalo every 3 hours. Alternatively, you can take a train from Florence to Buffalo via New York Penn Station and New York in around 21 h 21 min.

Airlines
American Airlines
Website
aa.com
Flights from Charlotte to Buffalo
Ave. Duration
1 h 42 min
When
Every day
Estimated price
$270 - $1,200
Flights from Charlotte to Buffalo via Reagan Washington
Ave. Duration
3 h 44 min
When
Monday to Friday
Estimated price
$270 - $1,200
Flights from Charlotte to Buffalo via Philadelphia
Ave. Duration
4 h 2 min
When
Monday
Estimated price
$270 - $1,200
Flights from Charleston to Buffalo via Reagan Washington
Ave. Duration
4 h 6 min
When
Every day
Estimated price
$500 - $1,300
Flights from Charleston to Buffalo via Philadelphia
Ave. Duration
4 h 13 min
When
Every day
Estimated price
$500 - $1,300
Flights from Charleston to Buffalo via Charlotte
Ave. Duration
4 h 40 min
When
Every day
Estimated price
$500 - $1,300
United Airlines
Website
united.com
Flights from Charlotte to Buffalo via Washington Dulles
Ave. Duration
3 h 47 min
When
Every day
Estimated price
$260 - $1,400
Flights from Charleston to Buffalo via Washington Dulles
Ave. Duration
3 h 42 min
When
Every day
Estimated price
$600 - $1,200
Flights from Charleston to Buffalo via Newark
Ave. Duration
4 h 41 min
When
Every day
Estimated price
$600 - $1,200
Southwest Airlines
Website
southwest.com
Flights from Charlotte to Buffalo via Baltimore
Ave. Duration
3 h 39 min
When
Every day
Estimated price
$310 - $1,200
Flights from Charleston to Buffalo via Baltimore
Ave. Duration
3 h 50 min
When
Every day
Estimated price
$600 - $1,300
Delta
Website
delta.com
Flights from Charleston to Buffalo via Atlanta
Ave. Duration
4 h 29 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$470 - $1,200
Flights from Charleston to Buffalo via New York JFK
Ave. Duration
4 h 23 min
When
Monday, Tuesday, Thursday and Friday
Estimated price
$470 - $1,200
Flights from Charleston to Buffalo via Detroit
Ave. Duration
4 h 32 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$470 - $1,200
JetBlue Airways
Website
jetblue.com
Flights from Charleston to Buffalo via New York JFK
Ave. Duration
4 h 23 min
When
Every day
Estimated price
$650 - $1,500
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Florence Amtrak to New York Penn Station
Ave. Duration
12 h 17 min
Frequency
Twice daily
Estimated price
$90 - $260
Website
amtrak.com
Coach Seat
$90 - $140
Flexi Coach Seat
$160 - $230
Business Coach Seat
$180 - $260
Room
$380 - $550
Train from New York Penn Station to Buffalo Exchange Street Amtrak
Ave. Duration
7 h 59 min
Frequency
3 times a day
Estimated price
$65 - $190
Website
amtrak.com
Coach Seat
$65 - $100
Flexi Coach Seat
$120 - $180
Business Coach Seat
$130 - $190
Room
$300 - $410
VIA Rail
Phone
+1 1 888 842-7245
Website
viarail.ca
Train from New York to Buffalo
Ave. Duration
8 h 9 min
Frequency
Every 3 hours
Estimated price
$60 - $210
Website
viarail.ca
Escape
$60 - $85
Economy
$100 - $140
Economy Plus
$140 - $210
Business
$150 - $210
Business Plus/Sleeper
$270 - $380
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Florence, Sc to Fayetteville, Nc
Ave. Duration
1 h 30 min
Frequency
Hourly
Estimated price
$14 - $35
Website
greyhound.com
Economy
$14 - $22
Flexible
$26 - $35
Bus from Fayetteville, Nc to Richmond, Va
Ave. Duration
4 h 55 min
Frequency
Every 15 minutes
Estimated price
$26 - $65
Website
greyhound.com
Economy
$26 - $45
Flexible
$45 - $65
Bus from Richmond, Va to Washington, Dc
Ave. Duration
2 h 20 min
Frequency
Every 15 minutes
Estimated price
$16 - $40
Website
greyhound.com
Economy
$16 - $25
Flexible
$29 - $40
bus
Bus from Fayetteville, NC to Arlington, VA
Ave. Duration
5 h 30 min
Frequency
5 times a week
Schedules at
lacubanabus.com

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More Questions & Answers

South Carolina to Buffalo train services, operated by VIA Rail, arrive at Buffalo station.

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Yes, the driving distance between South Carolina to Buffalo is 769 miles. It takes approximately 13 h 31 min to drive from South Carolina to Buffalo.

Get driving directions

American Airlines, Southwest Airlines and United Airlines offer flights from Charlotte Airport to Buffalo Airport.

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There are 136+ hotels available in Buffalo. Prices start at $67 USD per night.

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The best way to get from South Carolina to Charlotte Airport is to taxi which takes 35 min and costs .

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