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There are 6 ways to get from South Carolina to Buffalo by bus, plane, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Bus, fly to Buffalo  •  5h 15m

  1. Take the bus from White Street Park and Ride to Johnson & Wales Way & 4th St
  2. Fly from Charlotte (CLT) to Buffalo (BUF) CLT - BUF

$140 - $613

Cheapest option

Bus  •  23h 25m

  1. Take the bus from Florence, Sc to Fayetteville, Nc
  2. Take the bus from Fayetteville, Nc to Richmond, Va
  3. Take the bus from Richmond, Va to Washington, Dc
  4. Take the bus from Washington to Buffalo

$102 - $218

4 alternative options

Bus, fly to Rochester, train  •  7h 53m

  1. Take the bus from White Street Park and Ride to Johnson & Wales Way & 4th St
  2. Fly from Charlotte (CLT) to Rochester (ROC) CLT - ROC
  3. Take the train from Rochester Amtrak Station to Buffalo Amtrak Station

$165 - $717

Train, bus  •  20h 58m

  1. Take the train from Florence Amtrak Station to Washington Union Station Palmetto / ...
  2. Take the bus from Washington to Buffalo

$111 - $253

Train  •  21h 16m

  1. Take the train from Florence Amtrak Station to New York Penn Station Palmetto / ...
  2. Take the train from New York Penn Station to Buffalo Amtrak Station Maple Leaf / ...

$157 - $443

Drive  •  13h 31m

  1. Drive from Florence to Buffalo 769 miles

$75 - $110

Questions & Answers

The cheapest way to get from South Carolina to Buffalo is to drive which costs $75 - $110 and takes 13h 31m.

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The quickest way to get from South Carolina to Buffalo is to bus and fly which costs $140 - $650 and takes 5h 15m.

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No, there is no direct bus from South Carolina to Buffalo. However, there are services departing from Florence, Sc and arriving at Buffalo via Fayetteville, Nc, Richmond, Va and Washington. The journey, including transfers, takes approximately 23h 25m.

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No, there is no direct train from South Carolina station to Buffalo station. However, there are services departing from Florence Amtrak Station and arriving at Buffalo Amtrak Station via New York Penn Station. The journey, including transfers, takes approximately 21h 16m.

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The distance between South Carolina and Buffalo is 645 miles. The road distance is 769 miles.

Get driving directions

The best way to get from South Carolina to Buffalo without a car is to train and bus which takes 20h 58m and costs $110 - $260.

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It takes approximately 5h 15m to get from South Carolina to Buffalo, including transfers.

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South Carolina to Buffalo bus services, operated by Greyhound USA, depart from Florence, Sc station.

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South Carolina to Buffalo train services, operated by Amtrak, arrive at Florence Amtrak Station.

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The best way to get from South Carolina to Buffalo is to train which takes 21h 16m and costs $150 - $450. Alternatively, you can bus, which costs $100 - $220 and takes 23h 25m.

Mode details

Map of how to get from South Carolina to Buffalo.
Launch map view
  • Distance: 644.9 miles
  • Duration: 5h 15m

What companies run services between South Carolina, USA and Buffalo, NY, USA?

You can take a train from Florence to Buffalo via New York Penn Station in around 21h 16m. Alternatively, you can take a bus from Florence to Buffalo via Fayetteville, Nc, Richmond, Va, Washington, Dc, and Washington in around 23h 25m.

Airlines
American Airlines
Website
aa.com
Flights from Charlotte to Buffalo
Ave. Duration
1h 43m
When
Every day
Estimated price
$270 - $1,200
Flights from Charlotte to Buffalo via Reagan Washington
Ave. Duration
3h 45m
When
Every day
Estimated price
$270 - $1,200
Flights from Charlotte to Buffalo via Philadelphia
Ave. Duration
4h 3m
When
Every day
Estimated price
$270 - $1,200
Flights from Charlotte to Rochester
Ave. Duration
1h 47m
When
Every day
Estimated price
$200 - $1,300
Flights from Charlotte to Rochester via Reagan Washington
Ave. Duration
3h 50m
When
Every day
Estimated price
$200 - $1,300
Flights from Charlotte to Rochester via Philadelphia
Ave. Duration
4h 5m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$200 - $1,300
Southwest Airlines
Website
southwest.com
Flights from Charlotte to Buffalo via Baltimore
Ave. Duration
3h 43m
When
Every day
Estimated price
$310 - $1,200
Flights from Charlotte to Rochester via Baltimore
Ave. Duration
3h 47m
When
Every day
Estimated price
$210 - $1,300
United Airlines
Website
united.com
Flights from Charlotte to Buffalo via Washington Dulles
Ave. Duration
3h 39m
When
Every day
Estimated price
$260 - $1,400
Flights from Charlotte to Rochester via Washington Dulles
Ave. Duration
3h 51m
When
Every day
Estimated price
$220 - $1,100
Delta
Website
delta.com
Flights from Charlotte to Buffalo via Detroit
Ave. Duration
4h 4m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$260 - $1,000
Flights from Charlotte to Rochester via Detroit
Ave. Duration
4h 12m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$170 - $1,100
JetBlue Airways
Website
jetblue.com
Flights from Charlotte to Rochester via New York JFK
Ave. Duration
4h 11m
When
Every day
Estimated price
$180 - $1,500
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from Rochester Amtrak Station to Buffalo Amtrak Station
Ave. Duration
1h 17m
Frequency
3 times a day
Estimated price
$26 - $55
Website
amtrak.com
Coach Seat
$26 - $40
Flexi Coach Seat
$45 - $70
Business Coach Seat
$35 - $55
Room
$140 - $210
Train from Florence Amtrak Station to Washington Union Station
Ave. Duration
8h 3m
Frequency
Twice daily
Estimated price
$65 - $180
Website
amtrak.com
Coach Seat
$65 - $100
Flexi Coach Seat
$110 - $170
Business Coach Seat
$120 - $180
Room
$280 - $400
Train from Florence Amtrak Station to New York Penn Station
Ave. Duration
12h 17m
Frequency
Twice daily
Estimated price
$90 - $260
Website
amtrak.com
Coach Seat
$90 - $140
Flexi Coach Seat
$160 - $230
Business Coach Seat
$180 - $260
Room
$380 - $550
Train from New York Penn Station to Buffalo Amtrak Station
Ave. Duration
7h 59m
Frequency
3 times a day
Estimated price
$65 - $190
Website
amtrak.com
Coach Seat
$65 - $100
Flexi Coach Seat
$120 - $180
Business Coach Seat
$130 - $190
Room
$300 - $410
VIA Rail
Phone
+1 1 888 842-7245
Website
viarail.ca
Train from Rochester to Buffalo
Ave. Duration
1h 22m
Frequency
Once daily
Estimated price
$40 - $85
Website
viarail.ca
Escape
$19 - $40
Economy
$40 - $55
EconomyPlus
$55 - $85
Business
$55 - $80
Train from New York to Buffalo
Ave. Duration
8h 9m
Frequency
Once daily
Estimated price
$90 - $170
Website
viarail.ca
Escape
$65 - $90
Economy
$90 - $130
EconomyPlus
$120 - $170
Business
$160 - $220
Bus operators
Charlotte Area Transit System
Phone
+1 704-336-7433
Email
telltransit@charlottenc.gov
Website
charlottenc.gov
Bus from White Street Park and Ride to Johnson & Wales Way & 4th St
Ave. Duration
1h 1m
Frequency
3 times a day
Estimated price
$3 - $5
Schedules at
charlottenc.gov
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Florence, Sc to Fayetteville, Nc
Ave. Duration
1h 30m
Frequency
3 times a day
Estimated price
$14 - $35
Website
greyhound.com
Economy
$14 - $22
Flexible
$26 - $35
Bus from Fayetteville, Nc to Richmond, Va
Ave. Duration
4h 55m
Frequency
Hourly
Estimated price
$26 - $65
Website
greyhound.com
Economy
$26 - $45
Flexible
$45 - $65
Bus from Richmond, Va to Washington, Dc
Ave. Duration
2h 20m
Frequency
Hourly
Estimated price
$16 - $40
Website
greyhound.com
Economy
$16 - $25
Flexible
$29 - $40

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More Questions & Answers

The quickest flight from Charlotte Airport to Buffalo Airport is the direct flight which takes 1h 35m.

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South Carolina to Buffalo bus services, operated by Megabus, arrive at Buffalo station.

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South Carolina to Buffalo train services, operated by Amtrak, arrive at Buffalo Amtrak Station.

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Yes, the driving distance between South Carolina to Buffalo is 769 miles. It takes approximately 13h 31m to drive from South Carolina to Buffalo.

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Delta, United Airlines, Southwest Airlines and American Airlines offer flights from Charlotte Airport to Buffalo Airport.

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Book your South Carolina to Buffalo train tickets online with Rome2rio.

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There are 140+ hotels available in Buffalo. Prices start at $59 USD per night.

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