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There are 5 ways to get from South Bend to Kirksville by train, car, plane or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Train  •  7h 58m

  1. Take the train from South Bend Amtrak Station to Chicago Union Station Capitol Limited / ...
  2. Take the train from Chicago Union Station to La Plata Amtrak Station Southwest Chief

$108 - $238

4 alternative options

Drive  •  7h 56m

  1. Drive from South Bend to Kirksville 465.9 miles

$45 - $70

Train to Chicago Midway, fly to Kirksville  •  7h 27m

  1. Take the train from South Bend Amtrak Station to Chicago Union Station
  2. Fly from Chicago Midway (MDW) to Kirksville (IRK) MDW - IRK

$200 - $787

Train to Chicago Midway, fly to St. Louis, bus  •  11h 35m

  1. Take the train from South Bend Amtrak Station to Chicago Union Station
  2. Fly from Chicago Midway (MDW) to St. Louis (STL) MDW - STL
  3. Take the bus from St Louis, Mo to Kirksville

$183 - $437

Train to Chicago O'Hare, fly to Burlington, train  •  11h 10m

  1. Take the train from South Bend Amtrak Station to Chicago Union Station
  2. Fly from Chicago O'Hare (ORD) to Burlington (BRL) ORD - BRL
  3. Take the train from Burlington Amtrak Station to Galesburg Amtrak Station
  4. Take the train from Galesburg Amtrak Station to La Plata Amtrak Station

$176 - $305

Questions & Answers

The cheapest way to get from South Bend to Kirksville is to drive which costs $45 - $70 and takes 7h 56m.

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The quickest way to get from South Bend to Kirksville is to train and fly which costs $200 - $800 and takes 7h 27m.

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The distance between South Bend and Kirksville is 348 miles. The road distance is 465.9 miles.

Get driving directions

The best way to get from South Bend to Kirksville without a car is to train which takes 7h 58m and costs $100 - $240.

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It takes approximately 7h 58m to get from South Bend to Kirksville, including transfers.

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There is no direct flight from Chicago Midway Airport to Kirksville Airport. The quickest flight takes 9h 25m and has one stopover.

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Kirksville is 1h behind South Bend. It is currently 1:08 PM in South Bend and 12:08 PM in Kirksville.

Yes, the driving distance between South Bend to Kirksville is 466 miles. It takes approximately 7h 56m to drive from South Bend to Kirksville.

Get driving directions

Delta, Cape Air and Southwest Airlines offer flights from Chicago Midway Airport to Kirksville Airport.

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There are eight+ hotels available in Kirksville. Prices start at $100 USD per night.

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Map of how to get from South Bend to Kirksville.
Launch map view
  • Distance: 348.1 miles
  • Duration: 7h 58m

What companies run services between South Bend, IN, USA and Kirksville, MO, USA?

You can take a train from South Bend to Kirksville via Chicago Union Station and La Plata Amtrak Station in around 7h 58m.

Airlines
Southwest Airlines
Website
southwest.com
Flights from Chicago Midway to St. Louis
Ave. Duration
1h 11m
When
Every day
Estimated price
$160 - $550
Cape Air
Website
capeair.com
Flights from Chicago Midway to Kirksville via St. Louis
Ave. Duration
4h 24m
When
Every day
Estimated price
$150 - $700
Flights from Chicago Midway to Kirksville via Kansas City, St. Louis
Ave. Duration
6h
When
Monday to Friday
Estimated price
$190 - $800
Flights from Chicago Midway to Kirksville via Nashville, St. Louis
Ave. Duration
6h 30m
When
Sunday
Estimated price
$190 - $800
Flights from Chicago Midway to Kirksville via Minneapolis, St. Louis
Ave. Duration
7h
When
Sunday
Estimated price
$170 - $850
Flights from Chicago Midway to Kirksville via Atlanta, St. Louis
Ave. Duration
7h 45m
When
Sunday
Estimated price
$220 - $900
Flights from Chicago Midway to Kirksville via Detroit, St. Louis
Ave. Duration
7h 50m
When
Monday to Friday
Estimated price
$190 - $800
Air Choice One
Website
airchoiceone.com
Flights from Chicago O'Hare to Burlington
Ave. Duration
1h 40m
When
Every day
Estimated price
$50 - $120
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from South Bend Amtrak Station to Chicago Union Station
Ave. Duration
1h 54m
Frequency
3 times a day
Estimated price
$28 - $60
Website
amtrak.com
Coach Seat
$28 - $45
Flexi Coach Seat
$50 - $75
Business Coach Seat
$40 - $60
Room
$150 - $210
Train from Chicago Union Station to La Plata Amtrak Station
Ave. Duration
4h 47m
Frequency
Once daily
Estimated price
$50 - $140
Website
amtrak.com
Coach Seat
$50 - $80
Flexi Coach Seat
$90 - $140
Business Coach Seat
$95 - $140
Room
$240 - $330
Train from Burlington Amtrak Station to Galesburg Amtrak Station
Ave. Duration
1h 5m
Frequency
Once daily
Estimated price
$23 - $45
Website
amtrak.com
Coach Seat
$23 - $35
Flexi Coach Seat
$40 - $60
Business Coach Seat
$30 - $45
Room
$130 - $190
Train from Galesburg Amtrak Station to La Plata Amtrak Station
Ave. Duration
2h 11m
Frequency
Once daily
Estimated price
$30 - $80
Website
amtrak.com
Coach Seat
$30 - $50
Flexi Coach Seat
$60 - $85
Business Coach Seat
$55 - $80
Room
$170 - $240
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from St Louis, Mo to Kirksville
Ave. Duration
4h 40m
Frequency
Once daily
Estimated price
$28 - $70
Website
greyhound.com
Economy
$28 - $45
Flexible
$50 - $70

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.