Rome2Rio

How to get fromSimpsonville to St. Louisby plane, bus (Flixbus) or car

Find Transport to St. Louis

See all options

There are 6 ways to get from Simpsonville to St. Louis by plane, bus (Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Greenville–Spartanburg International Airport

    best
    1. Fly from Greenville–Spartanburg International Airport (GSP) to Lambert–St. Louis International Airport (STL)plane plane GSP - STL
    4h 49m
    $168–794

  2. Drive 661 mi

    cheapest
    1. Drive from Simpsonville to St. Louiscar car 661 mi
    11h 19m
    $121–175

  3. Bus

    1. Take the bus from Greenville, SC to Atlantabus bus Nyc
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus FlixBus N2521
    14h 55m
    $128–273

  4. Drive to Asheville Regional Airport, fly

    1. Drive from Simpsonville to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Lambert–St. Louis International Airport (STL)plane plane AVL - STL
    5h 50m
    $124–619

  5. Drive to Columbia, fly

    1. Drive from Simpsonville to Columbia-Airport-CAEcar car
    2. Fly from Columbia (CAE) to Lambert–St. Louis International Airport (STL)plane plane CAE - STL
    6h 9m
    $130–677

  6. Bus via Taqueria Guadalajara - Greenville

    1. Take the bus from Taqueria Guadalajara - Greenville to Atlantabus bus Charlotte
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus FlixBus N2521
    17h 24m
    $150–384

Greenville–Spartanburg International Airport (GSP) to Lambert–St. Louis International Airport (STL) flights

Calendar81Weekly Planes
Duration5h 5mAverage Duration
Ticket$130Cheapest Price
See schedules

Questions & Answers

What companies run services between Simpsonville, SC, USA and St. Louis, MO, USA?

Delta, American Airlines, and two other airlines fly from Greenville–Spartanburg International Airport (GSP) to Lambert–St. Louis International Airport (STL) every 2 hours. Alternatively, you can take a vehicle from Simpsonville to St Louis Bus Station via Greenville, SC, Atlanta, Buford Hwy @ Mcelroy Rd, Doraville Station, Doraville Station, Garnett Station, and Atlanta Bus Station in around 14h 55m.

Airlines
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Trips from Simpsonville

Trips to St. Louis

Popular routes