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How to get fromSimpsonville to St. Louisby plane, bus (Flixbus) or car

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There are 6 ways to get from Simpsonville to St. Louis by plane, bus (Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Greenville–Spartanburg International Airport

    best
    1. Fly from Greenville–Spartanburg International Airport (GSP) to Lambert–St. Louis International Airport (STL)plane plane GSP - STL
    4h 49m
    $158–794

  2. Drive to Asheville Regional Airport, fly

    cheapest
    1. Drive from Simpsonville to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Lambert–St. Louis International Airport (STL)plane plane AVL - STL
    5h 50m
    $114–619

  3. Bus

    1. Take the bus from Greenville, SC to Atlantabus bus Nyc
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus FlixBus N2521
    14h 55m
    $128–273

  4. Drive 661 mi

    1. Drive from Simpsonville to St. Louiscar car 661 mi
    11h 19m
    $121–175

  5. Drive to Columbia, fly

    1. Drive from Simpsonville to Columbia-Airport-CAEcar car
    2. Fly from Columbia (CAE) to Lambert–St. Louis International Airport (STL)plane plane CAE - STL
    6h 9m
    $130–627

  6. Bus via Taqueria Guadalajara - Greenville

    1. Take the bus from Taqueria Guadalajara - Greenville to Atlantabus bus Charlotte
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus FlixBus N2521
    17h 24m
    $150–384

Greenville–Spartanburg International Airport (GSP) to Lambert–St. Louis International Airport (STL) flights

Calendar76Weekly Planes
Duration5h 1mAverage Duration
Ticket$126Cheapest Price
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Questions & Answers

What companies run services between Simpsonville, SC, USA and St. Louis, MO, USA?

Delta, American Airlines, and two other airlines fly from Greenville–Spartanburg International Airport (GSP) to Lambert–St. Louis International Airport (STL) every 2 hours. Alternatively, you can take a vehicle from Simpsonville to St Louis Bus Station via Greenville, SC, Atlanta, Buford Hwy @ Mcelroy Rd, Doraville Station, Doraville Station, Garnett Station, and Atlanta Bus Station in around 14h 55m.

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