There are 5 ways to get from Simpsonville to St. Louis by plane, bus (Flixbus, Greyhound), or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Greenville–Spartanburg International Airport
best- Fly from Greenville–Spartanburg International Airport (GSP) to Lambert–St. Louis International Airport (STL)plane GSP - STL
4h 42m$162–749Drive 661.1 mi
cheapest- Drive from Simpsonville to St. Louiscar 661.1 mi
11h 19m$121–175Bus
- Take the bus from Taqueria Guadalajara - Greenville to Atlantabus Charlotte
- Take the bus from Atlanta Bus Station to St Louis Bus Stationbus FlixBus N2521
16h 2m$159–372Drive to Asheville Regional Airport, fly
- Drive from Simpsonville to Asheville-Airport-AVLcar
- Fly from Asheville Regional Airport (AVL) to Lambert–St. Louis International Airport (STL)plane AVL - STL
5h 30m$124–669Drive to Columbia, fly
- Drive from Simpsonville to Columbia-Airport-CAEcar
- Fly from Columbia (CAE) to Lambert–St. Louis International Airport (STL)plane CAE - STL
5h 55m$130–677
Greenville–Spartanburg International Airport (GSP) to Lambert–St. Louis International Airport (STL) flights
Questions & Answers
The cheapest way to get from Simpsonville to St. Louis is to drive which costs $120 - $180 and takes 11h 19m.
The fastest way to get from Simpsonville to St. Louis is to fly which takes 4h 42m and costs $160 - $750.
The distance between Simpsonville and St. Louis is 553 miles. The road distance is 664.9 miles.
The best way to get from Simpsonville to St. Louis without a car is to bus which takes 16h 2m and costs $150 - $380.
It takes approximately 4h 42m to get from Simpsonville to St. Louis, including transfers.
The best way to get from Simpsonville to St. Louis is to fly which takes 4h 42m and costs $160 - $750. Alternatively, you can bus, which costs $150 - $380 and takes 16h 2m.
St. Louis is 1h behind Simpsonville. It is currently 12:51 PM in Simpsonville and 11:51 AM in St. Louis.
Yes, the driving distance between Simpsonville to St. Louis is 665 miles. It takes approximately 11h 19m to drive from Simpsonville to St. Louis.
There are 918+ hotels available in St. Louis.
What companies run services between Simpsonville, SC, USA and St. Louis, MO, USA?
Delta, Southwest Airlines, and two other airlines fly from Greenville–Spartanburg International Airport (GSP) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a vehicle from Simpsonville to St Louis Bus Station via Taqueria Guadalajara - Greenville, Atlanta, Doraville Station, Garnett Station, and Atlanta Bus Station in around 16h 2m.
- Website
- aa.com
Flights from Greenville–Spartanburg International Airport to Lambert–St. Louis International Airport via Charlotte
- Ave. Duration
- 5h 18m
- When
- Every day
- Estimated price
- $130–750
Flights from Greenville–Spartanburg International Airport to Lambert–St. Louis International Airport via Chicago O'Hare
- Ave. Duration
- 6h 21m
- When
- Every day
- Estimated price
- $160–850
Flights from Asheville Regional Airport to Lambert–St. Louis International Airport via Charlotte
- Ave. Duration
- 5h 21m
- When
- Every day
- Estimated price
- $120–650
Flights from Asheville Regional Airport to Lambert–St. Louis International Airport via Chicago O'Hare
- Ave. Duration
- 6h 4m
- When
- Every day
- Estimated price
- $130–700
Flights from Asheville Regional Airport to Lambert–St. Louis International Airport via Reagan Washington
- Ave. Duration
- 6h 8m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $170–850
Flights from Columbia to Lambert–St. Louis International Airport via Charlotte
- Ave. Duration
- 5h 13m
- When
- Every day
- Estimated price
- $110–650
Flights from Columbia to Lambert–St. Louis International Airport via Reagan Washington
- Ave. Duration
- 6h 27m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $170–850
Flights from Columbia to Lambert–St. Louis International Airport via Dallas/Ft.Worth
- Ave. Duration
- 6h 6m
- When
- Every day
- Estimated price
- $210–1,000
Flights from Columbia to Lambert–St. Louis International Airport via Philadelphia
- Ave. Duration
- 6h 20m
- When
- Every day
- Estimated price
- $190–950
Flights from Columbia to Lambert–St. Louis International Airport via Chicago O'Hare
- Ave. Duration
- 7h 58m
- When
- Every day
- Estimated price
- $140–750
- Website
- delta.com
Flights from Greenville–Spartanburg International Airport to Lambert–St. Louis International Airport via Atlanta
- Ave. Duration
- 4h 27m
- When
- Every day
- Estimated price
- $130–750
Flights from Greenville–Spartanburg International Airport to Lambert–St. Louis International Airport via Detroit
- Ave. Duration
- 6h 41m
- When
- Every day
- Estimated price
- $180–900
Flights from Asheville Regional Airport to Lambert–St. Louis International Airport via Atlanta
- Ave. Duration
- 4h 47m
- When
- Every day
- Estimated price
- $110–650
Flights from Columbia to Lambert–St. Louis International Airport via Atlanta
- Ave. Duration
- 4h 28m
- When
- Every day
- Estimated price
- $120–650
- Website
- united.com
Flights from Greenville–Spartanburg International Airport to Lambert–St. Louis International Airport via Chicago O'Hare
- Ave. Duration
- 4h 52m
- When
- Friday, Wednesday, Monday, and Sunday
- Estimated price
- $160–850
Flights from Asheville Regional Airport to Lambert–St. Louis International Airport via Chicago O'Hare
- Ave. Duration
- 5h 15m
- When
- Every day
- Estimated price
- $130–700
Flights from Columbia to Lambert–St. Louis International Airport via Chicago O'Hare
- Ave. Duration
- 4h 56m
- When
- Every day
- Estimated price
- $140–750
Flights from Columbia to Lambert–St. Louis International Airport via Washington Dulles
- Ave. Duration
- 5h 35m
- When
- Monday to Friday
- Estimated price
- $160–850
Flights from Columbia to Lambert–St. Louis International Airport via Newark
- Ave. Duration
- 5h 49m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $210–1,000
- Website
- southwest.com
Flights from Greenville–Spartanburg International Airport to Lambert–St. Louis International Airport via Nashville
- Ave. Duration
- 4h 2m
- When
- Saturday and Sunday
- Estimated price
- $120–700
- Phone
- +1 888 358 6762
- info@tornadobus.com
- Website
- tornadobus.com
Bus from Taqueria Guadalajara - Greenville to Atlanta
- Ave. Duration
- 3h 23m
- Frequency
- Once daily
- Estimated price
- $45–150
- Schedules at
- tornadobus.com
- Adults 11-59
- $45–150
- Phone
- +1 (855) 626-8585
- Website
- https://www.flixbus.com
Bus from Atlanta Bus Station to St Louis Bus Station
- Ave. Duration
- 10h 36m
- Frequency
- Once daily
- Estimated price
- $70–120
- Schedules at
- flixbus.com
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Atlanta Bus Station to St Louis Bus Station
- Ave. Duration
- 11h 30m
- Frequency
- Once daily
- Estimated price
- $85–170
- Website
- https://www.greyhound.com/
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