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How to get fromSimpsonville to St. Louisby plane, bus (Flixbus, Greyhound), or car

Find Transport to St. Louis

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There are 5 ways to get from Simpsonville to St. Louis by plane, bus (Flixbus, Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Greenville–Spartanburg International Airport

    best
    1. Fly from Greenville–Spartanburg International Airport (GSP) to Lambert–St. Louis International Airport (STL)plane plane GSP - STL
    4h 42m
    $162–749

  2. Drive 661.1 mi

    cheapest
    1. Drive from Simpsonville to St. Louiscar car 661.1 mi
    11h 19m
    $121–175

  3. Bus

    1. Take the bus from Taqueria Guadalajara - Greenville to Atlantabus bus Charlotte
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus FlixBus N2521
    16h 2m
    $159–372

  4. Drive to Asheville Regional Airport, fly

    1. Drive from Simpsonville to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Lambert–St. Louis International Airport (STL)plane plane AVL - STL
    5h 30m
    $124–669

  5. Drive to Columbia, fly

    1. Drive from Simpsonville to Columbia-Airport-CAEcar car
    2. Fly from Columbia (CAE) to Lambert–St. Louis International Airport (STL)plane plane CAE - STL
    5h 55m
    $130–677

Greenville–Spartanburg International Airport (GSP) to Lambert–St. Louis International Airport (STL) flights

Calendar115Weekly Planes
Duration5h 7mAverage Duration
Ticket$123Cheapest Price
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Questions & Answers

What companies run services between Simpsonville, SC, USA and St. Louis, MO, USA?

Delta, Southwest Airlines, and two other airlines fly from Greenville–Spartanburg International Airport (GSP) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a vehicle from Simpsonville to St Louis Bus Station via Taqueria Guadalajara - Greenville, Atlanta, Doraville Station, Garnett Station, and Atlanta Bus Station in around 16h 2m.

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