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How to get fromSimpsonville to Florida Keysby plane, bus (Greyhound), taxi, bus, train, car or shuttle

Find Transport to Florida Keys

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There are 7 ways to get from Simpsonville to Florida Keys by plane, bus (Greyhound), taxi, bus, train, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Greenville–Spartanburg International Airport to Key West International Airport

    best
    1. Fly from Greenville–Spartanburg International Airport (GSP) to Key West International Airport (EYW)planeGSP - EYW
    7h 5m
    $192–710

  2. Drive to Asheville Regional Airport, fly to Key West International Airport

    cheapest
    1. Drive from Simpsonville to Asheville-Airport-AVLcar
    2. Fly from Asheville Regional Airport (AVL) to Key West International Airport (EYW)planeAVL - EYW
    6h 15m
    $143–565

  3. Bus

    1. Take the bus from Greenville, SC to AtlantabusNyc
    2. Take the bus from Atlanta Bus Station to Miami Airport Stationbus
    3. Take the bus from Miami Airport Station to Big Pine Keybus
    24h 25m
    $156–347

  4. Taxi, bus, train

    1. Take the taxi from Simpsonville to Servicios Zapata - Spartanburgtaxi
    2. Take the bus from Servicios Zapata - Spartanburg to Charlottebus
    3. Take the train from Charlotte Amtrak Station to Carytrain
    4. Take the train from Cary to Miami Amtrak Stationtrain
    5. Take the bus from Miami Airport Station to Big Pine Keybus
    36h 16m
    $277–1,136

  5. Drive 860.6 mi

    1. Drive from Simpsonville to Florida Keyscar860.6 mi
    14h 38m
    $158–227

  6. Fly Greenville–Spartanburg International Airport to Miami International Airport, shuttle

    1. Fly from Greenville–Spartanburg International Airport (GSP) to Miami International Airport (MIA)planeGSP - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle
    7h 50m
    $247–675

  7. Bus, shuttle

    1. Take the bus from Taqueria Guadalajara - Greenville to Charlottebus
    2. Take the bus from Charlotte Bus Station to Orlando Bus Stationbus
    3. Take the bus from Orlando Bus Station to Fort Lauderdale International Airportbus
    4. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Summerland Key - Mote Marine Labshuttle
    26h 59m
    $328–638

Greenville–Spartanburg International Airport (GSP) to Key West International Airport (EYW) flights

Calendar68Weekly Planes
Duration4h 51mAverage Duration
Ticket$113Cheapest Price
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Questions & Answers

What companies run services between Simpsonville, SC, USA and Florida Keys, FL, USA?

American Airlines, Delta, and Allegiant Air fly from Greenville–Spartanburg International Airport (GSP) to Key West International Airport (EYW) every 3 hours. Alternatively, you can take a vehicle from Simpsonville to Florida Keys via Greenville, SC, Atlanta, Buford Hwy @ Mcelroy Rd, Doraville Station, Doraville Station, Garnett Station, Atlanta Bus Station, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 24h 25m.

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