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How to get fromSimpsonville to Florida Keysby plane, bus (Greyhound), taxi, bus, train, car or shuttle

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There are 7 ways to get from Simpsonville to Florida Keys by plane, bus (Greyhound), taxi, bus, train, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Greenville–Spartanburg International Airport to Key West International Airport

    best
    1. Fly from Greenville–Spartanburg International Airport (GSP) to Key West International Airport (EYW)plane plane GSP - EYW
    7h 5m
    $192–760

  2. Drive to Asheville Regional Airport, fly to Key West International Airport

    cheapest
    1. Drive from Simpsonville to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Key West International Airport (EYW)plane plane AVL - EYW
    6h 26m
    $148–565

  3. Bus

    1. Take the bus from Greenville, SC to Atlantabus bus Nyc
    2. Take the bus from Atlanta Bus Station to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    24h 25m
    $156–347

  4. Taxi, bus, train

    1. Take the taxi from Simpsonville to Servicios Zapata - Spartanburgtaxi taxi
    2. Take the bus from Servicios Zapata - Spartanburg to Charlottebus bus
    3. Take the train from Charlotte Amtrak Station to Carytrain train
    4. Take the train from Cary to Miami Amtrak Stationtrain train
    5. Take the bus from Miami Airport Station to Big Pine Keybus bus
    36h 16m
    $277–1,136

  5. Drive 860.6 mi

    1. Drive from Simpsonville to Florida Keyscar car 860.6 mi
    14h 38m
    $158–227

  6. Fly Greenville–Spartanburg International Airport to Miami International Airport, shuttle

    1. Fly from Greenville–Spartanburg International Airport (GSP) to Miami International Airport (MIA)plane plane GSP - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    7h 50m
    $247–685

  7. Bus, shuttle

    1. Take the bus from Taqueria Guadalajara - Greenville to Charlottebus bus
    2. Take the bus from Charlotte Bus Station to Orlando Bus Stationbus bus
    3. Take the bus from Orlando Bus Station to Fort Lauderdale International Airportbus bus
    4. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Summerland Key - Mote Marine Labshuttle bus
    26h 59m
    $328–638

Greenville–Spartanburg International Airport (GSP) to Key West International Airport (EYW) flights

Calendar64Weekly Planes
Duration5hAverage Duration
Ticket$116Cheapest Price
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Questions & Answers

What companies run services between Simpsonville, SC, USA and Florida Keys, FL, USA?

American Airlines, Delta, and Allegiant Air fly from Greenville–Spartanburg International Airport (GSP) to Key West International Airport (EYW) every 3 hours. Alternatively, you can take a vehicle from Simpsonville to Florida Keys via Greenville, SC, Atlanta, Buford Hwy @ Mcelroy Rd, Doraville Station, Doraville Station, Garnett Station, Atlanta Bus Station, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 24h 25m.

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