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How to get fromSimpsonville to Florida Keysby plane, bus (Greyhound, Flixbus), taxi, bus, train, car or shuttle

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There are 7 ways to get from Simpsonville to Florida Keys by plane, bus (Greyhound, Flixbus), taxi, bus, train, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Greenville–Spartanburg International Airport to Key West International Airport

    best
    1. Fly from Greenville–Spartanburg International Airport (GSP) to Key West International Airport (EYW)plane plane GSP - EYW
    7h 10m
    $202–810

  2. Bus

    cheapest
    1. Take the bus from Greenville, SC to Atlantabus bus Nyc
    2. Take the bus from Atlanta Bus Station to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    27h 40m
    $147–347

  3. Taxi, bus, train

    1. Take the taxi from Simpsonville to Servicios Zapata - Spartanburgtaxi taxi
    2. Take the bus from Servicios Zapata - Spartanburg to Charlottebus bus
    3. Take the train from Charlotte Amtrak Station to Carytrain train
    4. Take the train from Cary to Miami Amtrak Stationtrain train
    5. Take the bus from Miami Airport Station to Big Pine Keybus bus
    36h 17m
    $268–636

  4. Drive 860.6 mi

    1. Drive from Simpsonville to Florida Keyscar car 860.6 mi
    14h 47m
    $158–227

  5. Drive to Asheville Regional Airport, fly to Key West International Airport

    1. Drive from Simpsonville to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Key West International Airport (EYW)plane plane AVL - EYW
    6h 26m
    $148–585

  6. Fly Greenville–Spartanburg International Airport to Miami International Airport, shuttle

    1. Fly from Greenville–Spartanburg International Airport (GSP) to Miami International Airport (MIA)plane plane GSP - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    7h 54m
    $252–705

  7. Fly Greenville–Spartanburg International Airport to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from Greenville–Spartanburg International Airport (GSP) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane GSP - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    8h 20m
    $507–795

Greenville–Spartanburg International Airport (GSP) to Key West International Airport (EYW) flights

Calendar65Weekly Planes
Duration4h 54mAverage Duration
Ticket$123Cheapest Price
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Questions & Answers

What companies run services between Simpsonville, SC, USA and Florida Keys, FL, USA?

American Airlines and Delta fly from Greenville–Spartanburg International Airport (GSP) to Key West International Airport (EYW) every 3 hours. Alternatively, you can take a vehicle from Simpsonville to Florida Keys via Greenville, SC, Atlanta, Buford Hwy @ Mcelroy Rd, Doraville Station, Doraville Station, Garnett Station, Atlanta Bus Station, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 27h 40m.

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