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How to get fromSimpsonville to Chicagoby plane, bus (Greyhound, Flixbus), taxi, bus, train, car or bus (Greyhound)

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There are 8 ways to get from Simpsonville to Chicago by plane, bus (Greyhound, Flixbus), taxi, bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Greenville–Spartanburg International Airport to Chicago O'Hare International Airport

    best
    1. Fly from Greenville–Spartanburg International Airport (GSP) to Chicago O'Hare International Airport (ORD)plane plane GSP - ORD
    3h 26m
    $106–451

  2. Drive to Asheville Regional Airport, fly to Chicago O'Hare International Airport

    cheapest
    1. Drive from Simpsonville to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Chicago O'Hare International Airport (ORD)plane plane AVL - ORD
    4h 13m
    $63–321

  3. Bus

    1. Take the bus from Taqueria Guadalajara - Greenville to Atlantabus bus Charlotte
    2. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus Greyhound US0100
    21h 26m
    $179–432

  4. Taxi, bus, train

    1. Take the taxi from Simpsonville to Servicios Zapata - Spartanburgtaxi taxi
    2. Take the bus from Servicios Zapata - Spartanburg to Charlottebus bus
    3. Take the train from Charlotte Amtrak Station to Raleigh Union Stationtrain train
    4. Take the train from Raleigh Union Station to Chicago Union Stationtrain train
    32h 56m
    $458–988

  5. Drive 681.9 mi

    1. Drive from Simpsonville to Chicagocar car 681.9 mi
    12h 57m
    $125–180

  6. Fly Greenville–Spartanburg International Airport to Chicago Midway International Airport

    1. Fly from Greenville–Spartanburg International Airport (GSP) to Chicago Midway International Airport (MDW)plane plane GSP - MDW
    4h 48m
    $141–651

  7. Drive to Columbia, fly to Chicago O'Hare International Airport

    1. Drive from Simpsonville to Columbia-Airport-CAEcar car
    2. Fly from Columbia (CAE) to Chicago O'Hare International Airport (ORD)plane plane CAE - ORD
    4h 47m
    $74–349

  8. Bus via 510 & 601 Connection

    1. Take the bus from Taqueria Guadalajara - Greenville to Atlantabus bus Charlotte
    2. Take the bus from Atlanta Bus Station to Chicago Train Stationbus bus Greyhound US0100
    22h 48m
    $186–416

Greenville–Spartanburg International Airport (GSP) to Chicago O'Hare International Airport (ORD) flights

Calendar89Weekly Planes
Duration3h 16mAverage Duration
Ticket$69Cheapest Price
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Questions & Answers

What companies run services between Simpsonville, SC, USA and Chicago, IL, USA?

American Airlines, United Airlines, and Delta fly from Greenville–Spartanburg International Airport (GSP) to Chicago O'Hare International Airport (ORD) hourly. Alternatively, you can take a vehicle from Simpsonville to Chicago Bus Station via Taqueria Guadalajara - Greenville, Atlanta, Doraville Station, Garnett Station, and Atlanta Bus Station in around 21h 26m.

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