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How to get fromSimpsonville to Chicagoby plane, bus (Flixbus, Greyhound), car or bus (Greyhound)

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There are 7 ways to get from Simpsonville to Chicago by plane, bus (Flixbus, Greyhound), car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Greenville–Spartanburg International Airport to Chicago O'Hare International Airport

    best
    1. Fly from Greenville–Spartanburg International Airport (GSP) to Chicago O'Hare International Airport (ORD)planeGSP - ORD
    3h 19m
    $287–596

  2. Drive to Asheville Regional Airport, fly to Chicago O'Hare International Airport

    cheapest
    1. Drive from Simpsonville to Asheville-Airport-AVLcar
    2. Fly from Asheville Regional Airport (AVL) to Chicago O'Hare International Airport (ORD)planeAVL - ORD
    4h 1m
    $58–301

  3. Bus

    1. Take the bus from Greenville, SC to AtlantabusNyc
    2. Take the bus from Atlanta Bus Station to Chicago Bus StationbusFlixBus 2512 / ...
    18h 40m
    $153–343

  4. Drive 683.1 mi

    1. Drive from Simpsonville to Chicagocar683.1 mi
    12h 48m
    $125–181

  5. Fly Greenville–Spartanburg International Airport to Chicago Midway International Airport

    1. Fly from Greenville–Spartanburg International Airport (GSP) to Chicago Midway International Airport (MDW)planeGSP - MDW
    4h 48m
    $127–596

  6. Drive to Columbia, fly to Chicago O'Hare International Airport

    1. Drive from Simpsonville to Columbia-Airport-CAEcar
    2. Fly from Columbia (CAE) to Chicago O'Hare International Airport (ORD)planeCAE - ORD
    4h 54m
    $99–479

  7. Bus via 510 & 601 Connection

    1. Take the bus from Greenville, SC to AtlantabusNyc
    2. Take the bus from Atlanta Bus Station to Chicago Train StationbusGreyhound US0100
    21h 14m
    $164–336

Greenville–Spartanburg International Airport (GSP) to Chicago O'Hare International Airport (ORD) flights

Calendar80Weekly Planes
Duration2h 48mAverage Duration
Ticket$65Cheapest Price
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Questions & Answers

What companies run services between Simpsonville, SC, USA and Chicago, IL, USA?

American Airlines, United Airlines, and Delta fly from Greenville–Spartanburg International Airport (GSP) to Chicago O'Hare International Airport (ORD) every 2 hours. Alternatively, you can take a vehicle from Simpsonville to Chicago Bus Station via Greenville, SC, Atlanta, Buford Hwy @ Mcelroy Rd, Doraville Station, Doraville Station, Garnett Station, and Atlanta Bus Station in around 18h 40m.

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Need to know: Greyhound

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