There are 9 ways to get from Sikeston to Destin by taxi, plane, train, bus, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Taxi to Cape Girardeau Municipal Airport, fly to Pensacola International Airport, taxi
best- Take the taxi from Sikeston to Cape Girardeau Municipal Airport (CGI)taxi
- Fly from Cape Girardeau Municipal Airport (CGI) to Pensacola International Airport (PNS)plane CGI - PNS
- Take the taxi from Pensacola-Airport-PNS to Destintaxi
3h 36m$351–944Drive 597.7 mi
cheapest- Drive from Sikeston to Destincar 597.7 mi
11h 1m$110–158Taxi, train, bus
- Take the taxi from Sikeston to Fulton Amtrak Stationtaxi
- Take the train from Fulton Amtrak Station to New Orleans Union Passenger Terminaltrain
- Take the bus from New Orleans Bus Station to Biloxi Transit Centerbus
- Take the bus from Biloxi to Crestviewbus
- Take the taxi from Crestview to Destintaxi
21h 55m$414–559Bus, taxi
- Take the bus from Flying J - Matthews to Tornado Bus Co - West Memphisbus
- Take the bus from Memphis Bus Station to Lafayettebus
- Take the bus from Lafayette to McDonald's - Crestviewbus
- Take the taxi from McDonald's - Crestview to Destintaxi
22h 25m$304–562Taxi, bus to Nashville, fly to Destin–Fort Walton Beach Airport
- Take the taxi from Sikeston to Paducah Bus Stationtaxi
- Take the bus from Paducah Bus Station to Nashville Bus Stationbus
- Fly from Nashville (BNA) to Destin–Fort Walton Beach Airport (VPS)plane BNA - VPS
7h 32m$260–622Taxi, bus to Midamerica St. Louis Airport, fly to Destin–Fort Walton Beach Airport
- Take the taxi from Sikeston to Cape Girardeautaxi
- Take the bus from Cape Girardeau to St Louis Bus Stationbus
- Fly from Midamerica St. Louis Airport (BLV) to Destin–Fort Walton Beach Airport (VPS)plane BLV - VPS
6h 45m$223–550Taxi, bus to Nashville, fly to Northwest Florida Beaches International Airport
- Take the taxi from Sikeston to Paducah Bus Stationtaxi
- Take the bus from Paducah Bus Station to Nashville Bus Stationbus
- Fly from Nashville (BNA) to Northwest Florida Beaches International Airport (ECP)plane BNA - ECP
- Take the taxi from Northwest Florida Beaches International Airport (ECP) to Destintaxi
8h 6m$340–717Taxi, bus to Nashville, fly to Pensacola International Airport
- Take the taxi from Sikeston to Paducah Bus Stationtaxi
- Take the bus from Paducah Bus Station to Nashville Bus Stationbus
- Fly from Nashville (BNA) to Pensacola International Airport (PNS)plane BNA - PNS
- Take the taxi from Pensacola-Airport-PNS to Destintaxi
8h 19m$400–677Taxi, bus
- Take the taxi from Sikeston to Cape Girardeautaxi
- Take the bus from Cape Girardeau to New Orleans Bus Stationbus
- Take the bus from New Orleans Bus Station to Biloxi Transit Centerbus
- Take the bus from Biloxi to Crestviewbus
- Take the taxi from Crestview to Destintaxi
23h$287–429
Cape Girardeau Municipal Airport (CGI) to Pensacola International Airport (PNS) flights
Questions & Answers
The cheapest way to get from Sikeston to Destin is to drive which costs $100 - $160 and takes 11h 1m.
The fastest way to get from Sikeston to Destin is to taxi and fly which takes 3h 36m and costs $350 - $950.
The distance between Sikeston and Destin is 570 miles. The road distance is 601.2 miles.
The best way to get from Sikeston to Destin without a car is to taxi and train and bus which takes 21h 55m and costs $410 - $600.
It takes approximately 3h 36m to get from Sikeston to Destin, including transfers.
Yes, the driving distance between Sikeston to Destin is 601 miles. It takes approximately 11h 1m to drive from Sikeston to Destin.
There are 6127+ hotels available in Destin.
What companies run services between Sikeston, MO, USA and Destin, FL, USA?
There is no direct connection from Sikeston to Destin. However, you can take the taxi to Cape Girardeau Municipal Airport (CGI) airport, fly to Pensacola International Airport (PNS), then take the taxi to Destin. Alternatively, you can take the taxi to Fulton Amtrak Station, take the train to New Orleans Union Passenger Terminal, walk to New Orleans Bus Station, take the bus to Biloxi Transit Center, walk to Biloxi, take the bus to Crestview, then take the taxi to Destin.
- Website
- southwest.com
Flights from Nashville to Destin–Fort Walton Beach Airport
- Ave. Duration
- 1h 36m
- When
- Every day
- Estimated price
- $50–340
Flights from Nashville to Northwest Florida Beaches International Airport
- Ave. Duration
- 1h 27m
- When
- Every day
- Estimated price
- $50–340
Flights from Nashville to Pensacola International Airport
- Ave. Duration
- 1h 33m
- When
- Every day
- Estimated price
- $65–410
- Website
- delta.com
Flights from Nashville to Destin–Fort Walton Beach Airport via Atlanta
- Ave. Duration
- 3h 23m
- When
- Every day
- Estimated price
- $55–350
Flights from Nashville to Northwest Florida Beaches International Airport via Atlanta
- Ave. Duration
- 3h 24m
- When
- Every day
- Estimated price
- $55–350
Flights from Nashville to Pensacola International Airport via Atlanta
- Ave. Duration
- 3h 31m
- When
- Monday, Thursday, and Friday
- Estimated price
- $70–430
- Website
- allegiantair.com
Flights from Midamerica St. Louis Airport to Destin–Fort Walton Beach Airport
- Ave. Duration
- 1h 46m
- When
- Monday, Wednesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $60–350
- Website
- contouraviation.com
Flights from Cape Girardeau Municipal Airport to Pensacola International Airport
- Ave. Duration
- 1h 45m
- When
- Wednesday and Saturday
- Estimated price
- $160–700
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Fulton Amtrak Station to New Orleans Union Passenger Terminal
- Ave. Duration
- 12h 33m
- Frequency
- Once daily
- Estimated price
- $120–190
- Website
- https://www.amtrak.com/home.html
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from New Orleans Bus Station to Biloxi Transit Center
- Ave. Duration
- 1h 45m
- Frequency
- Once daily
- Estimated price
- $17–25
- Website
- https://www.greyhound.com/
Bus from Cape Girardeau to St Louis Bus Station
- Ave. Duration
- 1h 50m
- Frequency
- Once daily
- Estimated price
- $22–26
- Website
- https://www.greyhound.com/
Bus from Cape Girardeau to New Orleans Bus Station
- Ave. Duration
- 14h 35m
- Frequency
- Once daily
- Estimated price
- $60–140
- Website
- https://www.greyhound.com/
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from New Orleans Bus Station to Biloxi Transit Center
- Ave. Duration
- 1h 25m
- Frequency
- 6 times a week
- Estimated price
- $17–26
- Schedules at
- flixbus.com
Bus from Memphis Bus Station to Lafayette
- Ave. Duration
- 10h
- Frequency
- 5 times a week
- Estimated price
- $70–95
- Schedules at
- flixbus.com
Bus from Paducah Bus Station to Nashville Bus Station
- Ave. Duration
- 2h 25m
- Frequency
- Once daily
- Estimated price
- $24–55
- Schedules at
- flixbus.com
- Phone
- +1 800-923-1799
- contactus@omexusa.net
- Website
- omnibusexpress.com
Bus from Biloxi to Crestview
- Ave. Duration
- 3h 10m
- Frequency
- Once daily
- Estimated price
- $55–75
- Schedules at
- omnibusexpress.com
- Phone
- +1 888 358 6762
- info@tornadobus.com
- Website
- tornadobus.com
Bus from Flying J - Matthews to Tornado Bus Co - West Memphis
- Ave. Duration
- 2h 20m
- Frequency
- Once daily
- Estimated price
- $45–140
- Schedules at
- tornadobus.com
- Adults 11-59
- $45–140
Bus from Lafayette to McDonald's - Crestview
- Ave. Duration
- 5h 40m
- Frequency
- Once daily
- Estimated price
- $70–180
- Schedules at
- tornadobus.com
- Adults 11-59
- $70–180
- Ave. Duration
- 1h 2m
- Estimated price
- $70–170
Choice Taxi
- Phone
- +1 850-529-1806
- Website
- mychoicetaxi.com
Able Shuttle and Taxi
- Phone
- +1 850-607-0209
Red Cabs of Panama City
- Phone
- +1 850-733-2227
- Website
- myfloridacabs.com
H2O Shuttle Taxi and Limo
- Phone
- +1 850-708-2870
Emerald Taxi
- Phone
- +1 850-792-2546
- Website
- emeraldtaxiandshuttle.com
Choice Taxi
- Phone
- +1 850-529-1806
- Website
- mychoicetaxi.com
Able Shuttle and Taxi
- Phone
- +1 850-607-0209
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Why you should take the train in the US
Read the travel guide
Need to know: Greyhound
Read the travel guide










