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There are 8 ways to get from Siena to Palermo by bus, plane, train, night bus, bus and ferry, car or ferry

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Bus to Florence, fly  •  5 h 16 min

  1. Take the bus from Siena-Via Tozzi to Leopolda
  2. Fly from Florence (FLR) to Palermo (PMO) FLR - PMO

$64 - $198

Cheapest option

Train, train to Pisa, fly  •  5 h 36 min

  1. Take the train from Siena to Empoli
  2. Take the train from Empoli to Pisa C.Le
  3. Fly from Pisa (PSA) to Palermo (PMO) PSA - PMO

$38 - $177

6 alternative options

Train, train to Bologna, fly  •  6 h 45 min

  1. Take the train from Siena to Firenze Smn
  2. Take the train from Firenze S.Maria Novella to Bologna C.Le
  3. Fly from Bologna (BLQ) to Palermo (PMO) BLQ - PMO

$52 - $238

Train via Napoli Centrale  •  15 h 4 min

  1. Take the train from Siena to Firenze Smn Reg / ...
  2. Take the train from Firenze S.Maria Novella to Napoli Centrale Fr
  3. Take the train from Napoli Centrale to Palermo Centrale Ic / ...

$102 - $171

Night bus, bus and ferry  •  15 h 40 min

  1. Take the night bus from Siena to Rome N997
  2. Take the bus and ferry from Rome Tiburtina to Palermo

$68 - $116

Bus  •  16 h 10 min

  1. Take the bus from SIENA - Pza Stazione FS-Fta SENA to PALERMO - PALERMO-P.Cairoli FS Baltour

$55 - $80

Drive, ferry  •  16 h 31 min

  1. Drive from Siena to Civitavecchia
  2. Take the ferry from Civitavecchia to Palermo

$113 - $160

Train  •  16 h 56 min

  1. Take the train from Siena to Chiusi-Chianciano Terme Reg
  2. Take the train from Chiusi-Chianciano Terme to Roma Termini Rv / ...
  3. Take the train from Roma Termini to Palermo Centrale Ic / ...

$103 - $159

Questions & Answers

The cheapest way to get from Siena to Palermo is to bus which costs 50€ - 70€ and takes 16 h 10 min.

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The quickest way to get from Siena to Palermo is to bus and fly which costs 55€ - 180€ and takes 5 h 16 min.

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Yes, there is a direct bus departing from SIENA - Pza Stazione FS-Fta SENA and arriving at PALERMO - PALERMO-P.Cairoli FS. Services depart twice daily, and operate every day. The journey takes approximately 16 h 10 min.

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No, there is no direct train from Siena to Palermo. However, there are services departing from Siena and arriving at Palermo Centrale via Firenze S.Maria Novella and Napoli Centrale. The journey, including transfers, takes approximately 15 h 4 min.

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The distance between Siena and Palermo is 601 km.

The best way to get from Siena to Palermo without a car is to train which takes 15 h 4 min and costs 85€ - 150€.

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It takes approximately 5 h 16 min to get from Siena to Palermo, including transfers.

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Siena to Palermo bus services, operated by Baltour, depart from SIENA - Pza Stazione FS-Fta SENA station.

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Siena to Palermo train services, operated by Trenitalia, depart from Siena station.

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The best way to get from Siena to Palermo is to train which takes 15 h 4 min and costs 85€ - 150€. Alternatively, you can bus, which costs 50€ - 70€ and takes 16 h 10 min.

Mode details

Map of how to get from Siena to Palermo.
Launch map view
  • Distance: 375.5 miles
  • Duration: 5 h 16 min

What companies run services between Siena, Italy and Palermo, Italy?

You can take a train from Siena to Palermo via Firenze Smn, Firenze S.Maria Novella, and Napoli Centrale in around 15 h 4 min. Alternatively, Baltour operates a bus from Siena to Palermo twice daily. Tickets cost $55 - $80 and the journey takes 16 h 10 min.

Airlines
Alitalia
Website
alitalia.com
Flights from Florence to Palermo via Rome
Ave. Duration
3 h 6 min
When
Every day
Estimated price
$80 - $280
Flights from Pisa to Palermo via Rome
Ave. Duration
3 h 16 min
When
Every day
Estimated price
$120 - $490
Flights from Bologna to Palermo via Rome
Ave. Duration
3 h 19 min
When
Every day
Estimated price
$75 - $330
Ryanair
Website
ryanair.com
Flights from Pisa to Palermo
Ave. Duration
1 h 25 min
When
Every day
Estimated price
$30 - $210
Flights from Bologna to Palermo
Ave. Duration
1 h 30 min
When
Every day
Estimated price
$30 - $350
Vueling Airlines
Website
vueling.com
Flights from Florence to Palermo
Ave. Duration
1 h 20 min
When
Monday, Friday and Sunday
Estimated price
$85 - $450
Train operators
Trenitalia

The primary train operator in Italy, Trenitalia was created in the year 2000. Trenitalia offers national rail connections in Italy as well as international connections to Austria, France, Germany and Switzerland. The company operates regional and long-distance trains, as well as high-speed trains called Frecce that travel on specialised tracks on speeds of up to 360km/h. Trenitalia tickets are available online, in stations across the country or from many travel agents that offer bookings.

Contact Details
Phone
+39 06 68475475
Website
trenitalia.com
Train from Siena to Empoli
Ave. Duration
1 h 2 min
Frequency
Every 30 minutes
Estimated price
$5 - $12
Website
orario.trenitalia.com
1st Class
$9 - $12
Train from Empoli to Pisa C.Le
Ave. Duration
30 min
Frequency
Every 20 minutes
Estimated price
$3 - $9
Website
orario.trenitalia.com
1st Class
$7 - $9
Train from Siena to Firenze Smn
Ave. Duration
1 h 32 min
Frequency
Hourly
Estimated price
$7 - $16
Website
orario.trenitalia.com
1st Class
$13 - $16
Train from Firenze Smn to Bologna C.Le
Ave. Duration
1 h 27 min
Frequency
Once daily
Estimated price
$7 - $16
Website
orario.trenitalia.com
1st Class
$13 - $16
Train from Siena to Chiusi-Chianciano Terme
Ave. Duration
1 h 25 min
Frequency
Hourly
Estimated price
$6 - $15
Website
orario.trenitalia.com
1st Class
$12 - $15
Train from Chiusi-Chianciano Terme to Roma Termini
Ave. Duration
1 h 52 min
Frequency
Every 2 hours
Estimated price
$11 - $24
Website
orario.trenitalia.com
1st Class
$20 - $24
Trenitalia Frecce

The primary train operator in Italy, Trenitalia was created in the year 2000. Trenitalia offers national rail connections in Italy as well as international connections to Austria, France, Germany and Switzerland. The company operates regional and long-distance trains, as well as high-speed trains called Frecce that travel on specialised tracks on speeds of up to 360km/h. Trenitalia tickets are available online, in stations across the country or from many travel agents that offer bookings.

Contact Details
Phone
+39 06 68475475
Website
trenitalia.com
Train from Firenze S.Maria Novella to Bologna C.Le
Ave. Duration
35 min
Frequency
Every 30 minutes
Estimated price
$15 - $23
Website
orario.trenitalia.com
Train from Firenze S.Maria Novella to Napoli Centrale
Ave. Duration
2 h 52 min
Frequency
Hourly
Estimated price
$55 - $80
Website
orario.trenitalia.com
ItaloTreno
Phone
+39 060708
Website
italotreno.it
Train from Firenze Santa Maria Novella Station to Bologna Centrale Station
Ave. Duration
39 min
Frequency
Hourly
Estimated price
$17 - $25
Website
italotreno.it
Train from Firenze Santa Maria Novella Station to Napoli Centrale Station
Ave. Duration
2 h 52 min
Frequency
Hourly
Estimated price
$35 - $55
Website
italotreno.it
Trenitalia Intercity

The primary train operator in Italy, Trenitalia was created in the year 2000. Trenitalia offers national rail connections in Italy as well as international connections to Austria, France, Germany and Switzerland. The company operates regional and long-distance trains, as well as high-speed trains called Frecce that travel on specialised tracks on speeds of up to 360km/h. Trenitalia tickets are available online, in stations across the country or from many travel agents that offer bookings.

Contact Details
Phone
+39 06 68475475
Website
trenitalia.com
Train from Napoli Centrale to Palermo Centrale
Ave. Duration
9 h 20 min
Frequency
3 times a day
Estimated price
$60 - $75
Website
orario.trenitalia.com
Train from Roma Termini to Palermo Centrale
Ave. Duration
11 h 39 min
Frequency
4 times a day
Estimated price
$85 - $120
Website
orario.trenitalia.com
Bus operators
FlixBus

One of Europe’s leading bus companies, Flixbus serves over 1400 destinations, in 26 countries including Germany, France, Italy, Austria, the Netherlands, Croatia, Spain, and across Scandinavia and central and eastern Europe. Founded in 2012, Flixbus’ extensive network connects cities with approximately 200,000 trips, with buses often departing every 30 minutes. One of the most affordable ways to get around Europe (and expanding soon into the US), a Flixbus journey is cost-effective, well-connected, comfortable and safe.

Rome2rio's guide to FlixBus
Contact Details
Phone
+49 1807 123 99 123
Email
info@flixbus.de
Website
flixbus.de
Night bus from Siena to Rome
Ave. Duration
2 h 45 min
Frequency
5 times a week
Estimated price
$13 - $22
Website
flixbus.co.uk
Autoservizi Salemi Srl
Phone
(+39) 0923 98.11.20
Website
autoservizisalemi.it
Bus and ferry from Rome Tiburtina to Palermo
Ave. Duration
11 h 55 min
Frequency
Once daily
Estimated price
$55 - $95
Schedules at
autoservizisalemi.it
Baltour
Phone
+39 0861 1991900
Email
info@baltour.it
Website
baltour.it
Bus from SIENA - Pza Stazione FS-Fta SENA to PALERMO - PALERMO-P.Cairoli FS
Ave. Duration
16 h 10 min
Frequency
Twice daily
Estimated price
$55 - $80
Website
http://www.baltour.it/
Ferry operators

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More Questions & Answers

The quickest flight from Florence Airport to Palermo Airport is the direct flight which takes 1 h 20 min.

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Siena to Palermo bus services, operated by Baltour, arrive at PALERMO - PALERMO-P.Cairoli FS station.

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Siena to Palermo train services, operated by Trenitalia Intercity, arrive at Palermo Centrale station.

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Vueling Airlines and Alitalia offer flights from Florence Airport to Palermo Airport.

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Book your Siena to Palermo train tickets online with Rome2rio.

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Book your Siena to Palermo bus tickets online with Distribusion and Busbud.

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There are 3119+ hotels available in Palermo. Prices start at $44 USD per night.

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