There are 9 ways to get from Siena to Palermo by bus, plane, car, ferry, train, or train (Trenitalia)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus to Florence Peretola Airport, fly
best- Take the bus from Siena-Via Tozzi to Firenze Autostazionebus
- Fly from Florence Peretola Airport (FLR) to Palermo Airport (PMO)plane FLR - PMO
5h 7mBus
cheapest- Take the bus from Siena to Palermobus N597
16h€30–150Drive, ferry
- Drive from Siena to Port of Naplescar
- Take the ferry from Port of Naples to Port of Palermoferry
12h 35m€107–152Bus, train
- Take the bus from Siena-Via Tozzi to Firenze Autostazionebus 131
- Take the train from Florence Santa Maria Novella to Roma Terminitrain
- Take the train from Roma Termini to Palermo Centraletrain Ic
16h 3mTrain, train to Pisa International Airport, fly
- Take the train from Siena to Empolitrain
- Take the train from Empoli to Pisa Centraletrain
- Fly from Pisa International Airport (PSA) to Palermo Airport (PMO)plane PSA - PMO
5h 35m€83–236Bus, train to Bologna Guglielmo Marconi Airport, fly
- Take the bus from Siena-Via Tozzi to Firenze Autostazionebus
- Take the train from Firenze S.M.N. to Bologna Centraletrain
- Fly from Bologna Guglielmo Marconi Airport (BLQ) to Palermo Airport (PMO)plane BLQ - PMO
5h 51mBus to Perugia Sant'Egidio Airport, fly
- Take the bus from Siena to Perugiabus
- Fly from Perugia Sant'Egidio Airport (PEG) to Palermo Airport (PMO)plane PEG - PMO
4h 56m€79–376Train (Trenitalia)
- Take the train from Siena to Chiusi-Chianciano T.train Re
- Take the train from Chiusi-Chianciano T. to Roma Terminitrain Re
- Take the train from Roma Termini to Palermo Centraletrain Ic
17h 51m€47–142Bus via Rome
- Take the bus from Siena - p.zza Rosselli to Roma, Autostazione Tiburtinabus Siena
- Take the bus from Roma, Autostazione Tiburtina to Palermo Terminal Busbus Itabus
18h 30m€65–75
Siena to Palermo by bus
Questions & Answers
The cheapest way to get from Siena to Palermo is to bus which costs €30 - €150 and takes 16h.
The fastest way to get from Siena to Palermo is to bus and fly which takes 4h 56m and costs €75 - €380.
Yes, there is a direct bus departing from Siena and arriving at Palermo. Services depart once daily, and operate every day. The journey takes approximately 16h.
The distance between Siena and Palermo is 750 km.
The best way to get from Siena to Palermo without a car is to bus which takes 16h and costs €30 - €150.
It takes approximately 5h 7m to get from Siena to Palermo, including transfers.
Siena to Palermo bus services, operated by FlixBus, depart from Siena station.
The best way to get from Siena to Palermo is to bus which takes 16h and costs €30 - €150. Alternatively, you can train, which costs €45 - €150 and takes 17h 51m.
Siena to Palermo bus services, operated by FlixBus, arrive at Palermo station.
Book your Siena to Palermo bus tickets online with Omio and FlixBus.
What companies run services between Siena, Italy and Palermo, Italy?
FlixBus operates a bus from Siena to Palermo once daily. Tickets cost €30–150 and the journey takes 16h. Alternatively, you can take a train from Siena to Piazza Boiardo via Chiusi-Chianciano T., Roma Termini, Palermo Centrale, and Stazione Centrale Pensilina Esterna in around 17h 51m.
- Website
- ryanair.com
Flights from Pisa International Airport to Palermo Airport
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- €55–210
Flights from Bologna Guglielmo Marconi Airport to Palermo Airport
- Ave. Duration
- 1h 30m
- When
- Every day
- Estimated price
- €30–230
Flights from Bologna Guglielmo Marconi Airport to Palermo Airport via Cagliari
- Ave. Duration
- 3h 25m
- When
- Friday
- Estimated price
- €30–230
Flights from Perugia Sant'Egidio Airport to Palermo Airport
- Ave. Duration
- 1h 15m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- €35–250
- Website
- ita-airways.com
Flights from Florence Peretola Airport to Palermo Airport via Rome
- Ave. Duration
- 3h 41m
- When
- Every day
- Estimated price
- €70–180
Flights from Bologna Guglielmo Marconi Airport to Palermo Airport via Rome
- Ave. Duration
- 3h 25m
- When
- Monday, Tuesday, Wednesday, Thursday, Saturday, and Sunday
- Estimated price
- €45–160
- Website
- volotea.com
Flights from Florence Peretola Airport to Palermo Airport
- Ave. Duration
- 1h 25m
- When
- Monday and Friday
- Estimated price
- €30–170
- Phone
- +39 06 8937 1892
- Website
- italotreno.it
Train from Florence Santa Maria Novella to Roma Termini
- Ave. Duration
- 1h 32m
- Frequency
- Hourly
- Estimated price
- €22–50
- Website
- https://www.italotreno.it/en
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Roma Termini to Palermo Centrale
- Ave. Duration
- 11h 44m
- Frequency
- Once daily
- Estimated price
- €27–110
- Website
- https://www.trenitalia.com/en.html
Train from Firenze S.M.N. to Bologna Centrale
- Ave. Duration
- 1h 17m
- Frequency
- Once daily
- Estimated price
- €9–15
- Website
- https://www.trenitalia.com/en.html
Train from Chiusi-Chianciano T. to Roma Termini
- Ave. Duration
- 2h 47m
- Frequency
- 3 times a day
- Estimated price
- €9–21
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Siena to Empoli
- Ave. Duration
- 1h 2m
- Frequency
- Hourly
- Estimated price
- €8
- Website
- https://www.trenitalia.com/en.html
Train from Empoli to Pisa Centrale
- Ave. Duration
- 46 min
- Frequency
- Every 30 minutes
- Estimated price
- €7
- Website
- https://www.trenitalia.com/en.html
Train from Firenze S.M.N. to Bologna Centrale
- Ave. Duration
- 1h 44m
- Frequency
- Twice daily
- Estimated price
- €10
- Website
- https://www.trenitalia.com/en.html
Train from Siena to Chiusi-Chianciano T.
- Ave. Duration
- 1h 28m
- Frequency
- Every 2 hours
- Estimated price
- €10
- Website
- https://www.trenitalia.com/en.html
Train from Chiusi-Chianciano T. to Roma Termini
- Ave. Duration
- 2h 5m
- Frequency
- Every 4 hours
- Estimated price
- €13
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Firenze S.M.N. to Bologna Centrale
- Ave. Duration
- 37 min
- Frequency
- Every 30 minutes
- Estimated price
- €15–40
- Schedules at
- trenitalia.com
- Phone
- +39 06 68475475
- ufficiogruppi@trenitalia.it
- Website
- trenitalia.com
Train from Firenze S.M.N. to Bologna Centrale
- Ave. Duration
- 1h 12m
- Frequency
- Once daily
- Estimated price
- €27–70
- Website
- https://www.trenitalia.com/en.html
- 1st Class
- €45–70
- 2nd Class
- €27–40
- Phone
- +39 055 849 0505
- servizioclienti@at-bus.it
- Website
- at-bus.it
Bus from Siena-Via Tozzi to Firenze Autostazione
- Ave. Duration
- 1h 15m
- Frequency
- Hourly
- Website
- https://www.at-bus.it/en
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Siena to Palermo
- Ave. Duration
- 16h
- Frequency
- Once daily
- Estimated price
- €30–150
- Website
- https://www.flixbus.co.uk
Bus from Siena to Perugia
- Ave. Duration
- 1h 25m
- Frequency
- Twice daily
- Estimated price
- €6–11
- Website
- https://www.flixbus.co.uk
Bus from Siena - p.zza Rosselli to Roma, Autostazione Tiburtina
- Ave. Duration
- 4h 15m
- Frequency
- Once daily
- Estimated price
- €10–15
- Schedules at
- autolineefederico.it
- Phone
- +39 06 88 93 82 32
- Website
- itabus.it
Bus from Roma, Autostazione Tiburtina to Palermo Terminal Bus
- Ave. Duration
- 13h 15m
- Frequency
- 3 times a week
- Estimated price
- €55–60
- Website
- https://www.itabus.it/en/home
- Phone
- +39.081.496.444
- info@grimaldi.napoli.it
- Website
- grimaldi-lines.com
Ferry from Port of Naples to Port of Palermo
- Ave. Duration
- 8h 30m
- Frequency
- Once daily
- Estimated price
- €40–55
- Website
- https://www.grimaldi-lines.com/en/
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