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How to get fromSiena to Palermoby bus, plane, car, ferry, train or train (Trenitalia)

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There are 9 ways to get from Siena to Palermo by bus, plane, car, ferry, train, or train (Trenitalia)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Florence Peretola Airport, fly

    best
    1. Take the bus from Siena-Via Tozzi to Firenze Autostazionebus bus
    2. Fly from Florence Peretola Airport (FLR) to Palermo Airport (PMO)plane plane FLR - PMO
    5h 7m
  2. Bus

    cheapest
    1. Take the bus from Siena to Palermobus bus N597
    16h
    €30–150
  3. Drive, ferry

    1. Drive from Siena to Port of Naplescar car
    2. Take the ferry from Port of Naples to Port of Palermoferry ferry
    12h 35m
    €107–152
  4. Bus, train

    1. Take the bus from Siena-Via Tozzi to Firenze Autostazionebus bus 131
    2. Take the train from Florence Santa Maria Novella to Roma Terminitrain train
    3. Take the train from Roma Termini to Palermo Centraletrain train Ic
    16h 3m
  5. Train, train to Pisa International Airport, fly

    1. Take the train from Siena to Empolitrain train
    2. Take the train from Empoli to Pisa Centraletrain train
    3. Fly from Pisa International Airport (PSA) to Palermo Airport (PMO)plane plane PSA - PMO
    5h 35m
    €83–236
  6. Bus, train to Bologna Guglielmo Marconi Airport, fly

    1. Take the bus from Siena-Via Tozzi to Firenze Autostazionebus bus
    2. Take the train from Firenze S.M.N. to Bologna Centraletrain train
    3. Fly from Bologna Guglielmo Marconi Airport (BLQ) to Palermo Airport (PMO)plane plane BLQ - PMO
    5h 51m
  7. Bus to Perugia Sant'Egidio Airport, fly

    1. Take the bus from Siena to Perugiabus bus
    2. Fly from Perugia Sant'Egidio Airport (PEG) to Palermo Airport (PMO)plane plane PEG - PMO
    4h 56m
    €79–376
  8. Train (Trenitalia)

    1. Take the train from Siena to Chiusi-Chianciano T.train train Re
    2. Take the train from Chiusi-Chianciano T. to Roma Terminitrain train Re
    3. Take the train from Roma Termini to Palermo Centraletrain train Ic
    17h 51m
    €47–142
  9. Bus via Rome

    1. Take the bus from Siena - p.zza Rosselli to Roma, Autostazione Tiburtinabus bus Siena
    2. Take the bus from Roma, Autostazione Tiburtina to Palermo Terminal Busbus bus Itabus
    18h 30m
    €65–75

Siena to Palermo by bus

Calendar7Weekly Buses
Duration16hAverage Duration
Ticket€30Cheapest Price
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Questions & Answers

What companies run services between Siena, Italy and Palermo, Italy?

FlixBus operates a bus from Siena to Palermo once daily. Tickets cost €30–150 and the journey takes 16h. Alternatively, you can take a train from Siena to Piazza Boiardo via Chiusi-Chianciano T., Roma Termini, Palermo Centrale, and Stazione Centrale Pensilina Esterna in around 17h 51m.

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