There are 9 ways to get from Siena to Palermo by car, plane, bus, train (Trenitalia), train, ferry, or car ferry
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Drive to Pisa International Airport, fly
best- Drive from Siena to Pisa International Airport (PSA)car
- Fly from Pisa International Airport (PSA) to Palermo Airport (PMO)plane PSA - PMO
4h 7m€56–222Bus to Perugia Sant'Egidio Airport, fly
cheapest- Take the bus from Siena to Perugiabus
- Fly from Perugia Sant'Egidio Airport (PEG) to Palermo Airport (PMO)plane PEG - PMO
6h 25m€43–283Bus
- Take the bus from Siena to Palermobus N597
16h€75–140Train (Trenitalia)
- Take the train from Siena to Firenze S.M.N.train Re
- Take the train from Firenze S.M.N. to Roma Terminitrain Fr
- Take the train from Roma Termini to Palermo Centraletrain Ic
16h 16m€123–295Bus, train, ferry
- Take the bus from Siena-Via Tozzi to Grosseto F.S.bus 51G
- Take the train from Grosseto to Civitavecchiatrain Re
- Take the ferry from Port of Civitavecchia to Port of Palermoferry
17h 16m€71–122Bus to Florence Peretola Airport, fly
- Take the bus from Siena-Via Tozzi to Firenze Autostazionebus
- Fly from Florence Peretola Airport (FLR) to Palermo Airport (PMO)plane FLR - PMO
5h 6m€61–165Bus, train to Bologna Guglielmo Marconi Airport, fly
- Take the bus from Siena-Via Tozzi to Firenze Autostazionebus
- Take the train from Firenze S.M.N. to Bologna Centraletrain
- Fly from Bologna Guglielmo Marconi Airport (BLQ) to Palermo Airport (PMO)plane BLQ - PMO
5h 54m€53–233Train via Chiusi (Trenitalia)
- Take the train from Siena to Chiusi-Chianciano T.train Re
- Take the train from Chiusi-Chianciano T. to Roma Terminitrain Re
- Take the train from Roma Termini to Palermo Centraletrain Ic
17h 54m€112–256Drive, car ferry
- Drive from Siena to Livornocar
- Take the car ferry from Livorno to Port of Palermocarferry
21h 20m€68–121
Siena to Palermo by bus
Questions & Answers
The cheapest way to get from Siena to Palermo is to drive and car ferry which costs €65 - €130 and takes 21h 20m.
The fastest way to get from Siena to Palermo is to drive and fly which takes 4h 7m and costs €55 - €230.
Yes, there is a direct bus departing from Siena and arriving at Palermo. Services depart once daily, and operate every day. The journey takes approximately 16h.
No, there is no direct train from Siena to Palermo. However, there are services departing from Siena and arriving at Palermo Centrale via Firenze S.M.N. and Roma Termini. The journey, including transfers, takes approximately 16h 16m.
The distance between Siena and Palermo is 795 km.
The best way to get from Siena to Palermo without a car is to bus which takes 16h and costs €75 - €140.
It takes approximately 4h 7m to get from Siena to Palermo, including transfers.
Siena to Palermo bus services, operated by FlixBus, depart from Siena station.
Siena to Palermo train services, operated by Trenitalia, depart from Siena station.
The best way to get from Siena to Palermo is to bus which takes 16h and costs €75 - €140. Alternatively, you can train, which costs €120 - €300 and takes 16h 16m.
What companies run services between Siena, Italy and Palermo, Italy?
FlixBus operates a bus from Siena to Palermo once daily. Tickets cost €75–140 and the journey takes 16h. Alternatively, you can take a train from Siena to Palermo Centrale via Firenze S.M.N. and Roma Termini in around 16h 16m.
- Website
- ryanair.com
Flights from Pisa International Airport to Palermo Airport
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- €35–180
Flights from Bologna Guglielmo Marconi Airport to Palermo Airport
- Ave. Duration
- 1h 30m
- When
- Every day
- Estimated price
- €30–140
Flights from Bologna Guglielmo Marconi Airport to Palermo Airport via Alghero
- Ave. Duration
- 3h 35m
- When
- Tuesday
- Estimated price
- €30–140
Flights from Perugia Sant'Egidio Airport to Palermo Airport
- Ave. Duration
- 1h 15m
- When
- Monday, Tuesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- €30–220
- Website
- ita-airways.com
Flights from Florence Peretola Airport to Palermo Airport via Rome
- Ave. Duration
- 3h 12m
- When
- Every day
- Estimated price
- €70–140
Flights from Bologna Guglielmo Marconi Airport to Palermo Airport via Rome
- Ave. Duration
- 3h 12m
- When
- Every day
- Estimated price
- €50–130
- Website
- volotea.com
Flights from Florence Peretola Airport to Palermo Airport
- Ave. Duration
- 1h 25m
- When
- Monday, Thursday, and Friday
- Estimated price
- €35–120
- Website
- flyulendo.com
Flights from Bologna Guglielmo Marconi Airport to Palermo Airport
- Ave. Duration
- 1h 35m
- When
- Every day
- Estimated price
- €20–120
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Siena to Firenze S.M.N.
- Ave. Duration
- 1h 34m
- Frequency
- Hourly
- Estimated price
- €11–20
- Website
- https://www.trenitalia.com/en.html
Train from Firenze S.M.N. to Roma Termini
- Ave. Duration
- 3h 51m
- Frequency
- 4 times a day
- Estimated price
- €30–55
- Website
- https://www.trenitalia.com/en.html
Train from Grosseto to Civitavecchia
- Ave. Duration
- 1h 14m
- Frequency
- Every 2 hours
- Estimated price
- €13–23
- Website
- https://www.trenitalia.com/en.html
Train from Firenze S.M.N. to Bologna Centrale
- Ave. Duration
- 1h 28m
- Frequency
- Twice daily
- Estimated price
- €11–20
- Website
- https://www.trenitalia.com/en.html
Train from Siena to Chiusi-Chianciano T.
- Ave. Duration
- 1h 28m
- Frequency
- Every 2 hours
- Estimated price
- €11–19
- Website
- https://www.trenitalia.com/en.html
Train from Chiusi-Chianciano T. to Roma Termini
- Ave. Duration
- 2h 5m
- Frequency
- Every 4 hours
- Estimated price
- €19–35
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Firenze S.M.N. to Roma Termini
- Ave. Duration
- 1h 42m
- Frequency
- Every 30 minutes
- Estimated price
- €35–75
- Schedules at
- trenitalia.com
Train from Grosseto to Civitavecchia
- Ave. Duration
- 50 min
- Frequency
- 5 times a day
- Estimated price
- €15–29
- Schedules at
- trenitalia.com
Train from Firenze S.M.N. to Bologna Centrale
- Ave. Duration
- 37 min
- Frequency
- Every 30 minutes
- Estimated price
- €13–25
- Schedules at
- trenitalia.com
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Firenze S.M.N. to Roma Termini
- Ave. Duration
- 2h 40m
- Frequency
- 6 times a week
- Estimated price
- €26–60
- Website
- https://www.trenitalia.com/en.html
Train from Roma Termini to Palermo Centrale
- Ave. Duration
- 11h 44m
- Frequency
- Once daily
- Estimated price
- €85–200
- Website
- https://www.trenitalia.com/en.html
Train from Grosseto to Civitavecchia
- Ave. Duration
- 53 min
- Frequency
- 3 times a day
- Estimated price
- €10–25
- Website
- https://www.trenitalia.com/en.html
Train from Firenze S.M.N. to Bologna Centrale
- Ave. Duration
- 1h 17m
- Frequency
- Once daily
- Estimated price
- €9–21
- Website
- https://www.trenitalia.com/en.html
Train from Chiusi-Chianciano T. to Roma Termini
- Ave. Duration
- 2h 47m
- Frequency
- 3 times a day
- Estimated price
- €14–35
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- ufficiogruppi@trenitalia.it
- Website
- trenitalia.com
Train from Firenze S.M.N. to Bologna Centrale
- Ave. Duration
- 1h 12m
- Frequency
- Once daily
- Estimated price
- €27–70
- Website
- https://www.trenitalia.com/en.html
- 1st Class
- €45–70
- 2nd Class
- €27–40
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Siena to Palermo
- Ave. Duration
- 16h
- Frequency
- Once daily
- Estimated price
- €75–140
- Website
- https://www.flixbus.co.uk
Bus from Siena to Perugia
- Ave. Duration
- 1h 25m
- Frequency
- Twice daily
- Estimated price
- €6–12
- Website
- https://www.flixbus.co.uk
- Phone
- +39 800 142 424
- numeroverdetpl@regione.toscana.it
- Website
- at-bus.it
Bus from Siena-Via Tozzi to Grosseto F.S.
- Ave. Duration
- 1h 15m
- Frequency
- Every 2 hours
- Estimated price
- €5–7
- Website
- https://www.at-bus.it/en
- Schedules at
- https://www.at-bus.it/en/lines-and-timetables
Bus from Siena-Via Tozzi to Firenze Autostazione
- Ave. Duration
- 1h 15m
- Frequency
- Hourly
- Estimated price
- €4–6
- Website
- https://www.at-bus.it/en
- Schedules at
- https://www.at-bus.it/en/lines-and-timetables
- Phone
- +39 010 209 4591
- booking@gnv.it
- Website
- gnv.it
Ferry from Port of Civitavecchia to Port of Palermo
- Ave. Duration
- 12h
- Frequency
- Once a week
- Estimated price
- €55–85
- Website
- https://www.gnv.it/en
- Phone
- +39.081.496.444
- info@grimaldi.napoli.it
- Website
- grimaldi-lines.com
Car ferry from Livorno to Port of Palermo
- Ave. Duration
- 19h 30m
- Frequency
- 3 times a week
- Estimated price
- €50–95
- Website
- https://www.grimaldi-lines.com/en/
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More Questions & Answers
Siena to Palermo bus services, operated by FlixBus, arrive at Palermo station.
Siena to Palermo train services, operated by Trenitalia, arrive at Firenze S.M.N. station.
Book your Siena to Palermo train tickets online with Omio.
Book your Siena to Palermo bus tickets online with Omio and FlixBus.
There are 5879+ hotels available in Palermo.





























