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How to get fromSiena to Mainzby train, plane, train (Trenitalia), bus, or car

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There are 10 ways to get from Siena to Mainz by train, plane, train (Trenitalia), bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Florence Peretola Airport, fly

    best
    1. Take the train from Siena to Firenze Rifreditrain train
    2. Fly from Florence Peretola Airport (FLR) to Frankfurt (FRA)plane plane FLR - FRA
    6h 7m
    €137–343

  2. Bus

    cheapest
    1. Take the bus from Siena to Florence Villa Constanza Bus Stationbus bus 1509 / ...
    2. Take the bus from Florence Villa Constanza Bus Station to Frankfurt central train stationbus bus N77 / ...
    21h
    €81–143

  3. Train via Basel

    1. Take the train from Siena to Firenze S.M.N.train train Re
    2. Take the train from Firenze S.M.N. to Milano Centraletrain train Fr
    3. Take the train from Milano Centrale to Basel Sbbtrain train Ec
    4. Take the train from Basel SBB to Mannheim, Hauptbahnhoftrain train 12 / ...
    5. Take the train from Mannheim, Hauptbahnhof to Mainz, Hauptbahnhoftrain train 55 / ...
    12h 23m
    €175–444

  4. Bus, train

    1. Take the bus from Siena-Via Tozzi to Firenze Autostazionebus bus 131
    2. Take the bus from Florence Villa Constanza Bus Station to Stuttgart Airportbus bus
    3. Take the train from Hauptbahnhof to Mannheim, Hauptbahnhoftrain train 47 / ...
    4. Take the train from Mannheim, Hauptbahnhof to Mainz, Römisches Theatertrain train S5 / ...
    17h 44m

  5. Drive 1,023.7 km

    1. Drive from Siena to Mainzcar car 1,023.7 km
    9h 49m
    €163–235

  6. Train, train to Pisa International Airport, fly

    1. Take the train from Siena to Empolitrain train
    2. Take the train from Empoli to Pisa Centraletrain train
    3. Fly from Pisa International Airport (PSA) to Frankfurt (FRA)plane plane PSA - FRA
    6h 24m
    €123–293

  7. Train, train to Bologna Guglielmo Marconi Airport, fly

    1. Take the train from Siena to Firenze S.M.N.train train
    2. Take the train from Firenze S.M.N. to Bologna Centraletrain train
    3. Fly from Bologna Guglielmo Marconi Airport (BLQ) to Frankfurt (FRA)plane plane BLQ - FRA
    6h 38m
    €126–352

  8. Train, train to Venice Marco Polo Airport, fly

    1. Take the train from Siena to Firenze S.M.N.train train
    2. Take the train from Firenze S.M.N. to Venezia Mestretrain train
    3. Fly from Venice Marco Polo Airport (VCE) to Frankfurt (FRA)plane plane VCE - FRA
    8h 23m
    €118–364

  9. Train, train to Verona Villafranca Airport, fly

    1. Take the train from Siena to Firenze S.M.N.train train
    2. Take the train from Firenze S.M.N. to Verona Porta Nuovatrain train
    3. Fly from Verona Villafranca Airport (VRN) to Frankfurt (FRA)plane plane VRN - FRA
    8h 9m
    €173–399

  10. Train

    1. Take the train from Siena to Firenze S.M.N.train train Re
    2. Take the train from Firenze S.M.N. to Milano Centraletrain train Fr
    3. Take the train from Milano Centrale to Mannheim Hbftrain train Ec
    4. Take the train from Mannheim, Hauptbahnhof to Mainz, Römisches Theatertrain train S5 / ...
    13h 12m
    €175–309

Siena to Mainz by train

Calendar92Weekly Trains
Duration12h 23mAverage Duration
Ticket€175Cheapest Price
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Questions & Answers

Map of how to get from Siena to Mainz.ExpandLaunch map view
  • Distance: 844.6 km
  • Duration: 6h 7m

What companies run services between Siena, Italy and Mainz, Germany?

You can take a train from Siena to Mainz, Hauptbahnhof via Firenze S.M.N., Milano Centrale, Basel SBB, and Mannheim, Hauptbahnhof in around 12h 23m. Alternatively, you can take a bus from Siena to Mainz central train station via Florence Villa Constanza Bus Station and Frankfurt central train station in around 21h.

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