There are 7 ways to get from Siena to Mainz by bus, plane, train, car, or car train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus to Florence Peretola Airport, fly
best- Take the bus from Siena-Via Tozzi to Firenze Autostazionebus
- Fly from Florence Peretola Airport (FLR) to Frankfurt (FRA)plane FLR - FRA
5h 51m€112–331Bus
cheapest- Take the bus from Siena to Florence Villa Constanza Bus Stationbus 1509 / ...
- Take the bus from Florence Villa Constanza Bus Station to Frankfurt central train stationbus N77 / ...
21h€71–132Bus, train
- Take the bus from Siena-Via Tozzi to Firenze Autostazionebus 131
- Take the train from Firenze S.M.N. to Milano Centraletrain Fr
- Take the train from Milano Centrale to Mannheim Hbftrain Ec
- Take the train from Mannheim, Hauptbahnhof to Mainz, Römisches Theatertrain S5 / ...
13h 25m€169–293Drive 1,023.6 km
- Drive from Siena to Mainzcar 1,023.6 km
9h 49m€161–232Bus, train to Bologna Guglielmo Marconi Airport, fly
- Take the bus from Siena-Via Tozzi to Firenze Autostazionebus
- Take the train from Firenze S.M.N. to Bologna Centraletrain
- Fly from Bologna Guglielmo Marconi Airport (BLQ) to Frankfurt (FRA)plane BLQ - FRA
6h 32m€119–359Bus, train via Munich
- Take the bus from Siena-Via Tozzi to Firenze Autostazionebus 131
- Take the train from Firenze S.M.N. to Bologna Centraletrain Fr
- Take the train from Bologna Centrale to München Hbftrain 89
- Take the train from München Hbf to Frankfurttrain 47 / ...
14h 1m€154–474Drive, car train
- Drive from Siena to München Ostcar
- Take the car train from München Ost to Würzburg Hbfcartrain
- Drive from Würzburg Hbf to Mainzcar
10h 4m€216–294
Siena to Mainz by bus and train
Questions & Answers
The cheapest way to get from Siena to Mainz is to bus which costs €70 - €140 and takes 21h.
The fastest way to get from Siena to Mainz is to bus and fly which takes 5h 51m and costs €110 - €340.
No, there is no direct bus from Siena to Mainz station. However, there are services departing from Siena and arriving at Mainz central train station via Florence Villa Constanza Bus Station and Frankfurt central train station. The journey, including transfers, takes approximately 21h.
The distance between Siena and Mainz is 824 km. The road distance is 1023.6 km.
The best way to get from Siena to Mainz without a car is to bus and train which takes 13h 25m and costs €160 - €300.
It takes approximately 5h 51m to get from Siena to Mainz, including transfers.
Siena to Mainz bus services, operated by FlixBus, depart from Siena station.
Siena to Mainz bus services, operated by FlixBus, arrive at Florence Villa Constanza Bus Station.
Yes, the driving distance between Siena to Mainz is 1024 km. It takes approximately 9h 49m to drive from Siena to Mainz.
Book your Siena to Mainz bus tickets online with FlixBus.
What companies run services between Siena, Italy and Mainz, Germany?
You can take a bus from Siena to Mainz central train station via Florence Villa Constanza Bus Station and Frankfurt central train station in around 21h.
- Website
- lufthansa.com
Flights from Florence Peretola Airport to Frankfurt
- Ave. Duration
- 1h 35m
- When
- Every day
- Estimated price
- €110–400
Flights from Florence Peretola Airport to Frankfurt via Munich
- Ave. Duration
- 3h 37m
- When
- Every day
- Estimated price
- €110–400
Flights from Bologna Guglielmo Marconi Airport to Frankfurt
- Ave. Duration
- 1h 30m
- When
- Every day
- Estimated price
- €90–440
Flights from Bologna Guglielmo Marconi Airport to Frankfurt via Munich
- Ave. Duration
- 3h
- When
- Every day
- Estimated price
- €100–480
- Website
- airdolomiti.it
Flights from Florence Peretola Airport to Frankfurt
- Ave. Duration
- 1h 35m
- When
- Every day
- Estimated price
- €110–400
Flights from Bologna Guglielmo Marconi Airport to Frankfurt
- Ave. Duration
- 1h 30m
- When
- Every day
- Estimated price
- €100–440
- Website
- swiss.com
Flights from Florence Peretola Airport to Frankfurt via Zurich
- Ave. Duration
- 3h 35m
- When
- Every day
- Estimated price
- €120–260
Flights from Bologna Guglielmo Marconi Airport to Frankfurt via Zurich
- Ave. Duration
- 3h 17m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- €75–290
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Firenze S.M.N. to Milano Centrale
- Ave. Duration
- 1h 55m
- Frequency
- Hourly
- Estimated price
- €40–85
- Schedules at
- trenitalia.com
Train from Firenze S.M.N. to Bologna Centrale
- Ave. Duration
- 37 min
- Frequency
- Hourly
- Estimated price
- €13–25
- Schedules at
- trenitalia.com
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Firenze S.M.N. to Milano Centrale
- Ave. Duration
- 3h 54m
- Frequency
- Once daily
- Estimated price
- €30–70
- Website
- https://www.trenitalia.com/en.html
Train from Firenze S.M.N. to Bologna Centrale
- Ave. Duration
- 1h 17m
- Frequency
- Once daily
- Estimated price
- €9–21
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- ufficiogruppi@trenitalia.it
- Website
- trenitalia.com
Train from Milano Centrale to Mannheim Hbf
- Ave. Duration
- 6h 48m
- Frequency
- Once daily
- Estimated price
- €120–180
- Website
- https://www.trenitalia.com/en.html
- 1st Class
- €120–180
- 2nd Class
- €120–160
Train from Firenze S.M.N. to Bologna Centrale
- Ave. Duration
- 1h 12m
- Frequency
- Once daily
- Estimated price
- €27–70
- Website
- https://www.trenitalia.com/en.html
- 1st Class
- €45–70
- 2nd Class
- €27–40
- Phone
- +49 30 2970
- Website
- bahn.de
Train from Mannheim, Hauptbahnhof to Mainz, Römisches Theater
- Ave. Duration
- 1h 17m
- Frequency
- Hourly
- Estimated price
- €14–22
- Website
- https://int.bahn.de/en
- Phone
- 0621 8301200
- Website
- suewex.de
Train from Mannheim, Hauptbahnhof to Mainz, Römisches Theater
- Ave. Duration
- 57 min
- Frequency
- 5 times a week
- Estimated price
- €14–20
- Schedules at
- suewex.de
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Firenze S.M.N. to Bologna Centrale
- Ave. Duration
- 1h 28m
- Frequency
- Twice daily
- Estimated price
- €11–20
- Website
- https://www.trenitalia.com/en.html
- Phone
- +49 30 311 682904
- Website
- bahn.de
Train from Bologna Centrale to München Hbf
- Ave. Duration
- 6h 33m
- Frequency
- Once daily
- Estimated price
- €95–220
- Website
- https://int.bahn.de/en
Train from München Hbf to Frankfurt
- Ave. Duration
- 3h 19m
- Frequency
- Hourly
- Estimated price
- €70–170
- Website
- https://int.bahn.de/en
- Phone
- +31 30 751 5155
- Website
- ns.nl
Train from München Hbf to Frankfurt
- Ave. Duration
- 3h 18m
- Frequency
- Once daily
- Estimated price
- €40–110
- Website
- https://www.ns.nl/en
- Phone
- +49 (0) 221 800 20 820
- info@urlaubs-express.de
- Website
- urlaubs-express.de
Car train from München Ost to Würzburg Hbf
- Ave. Duration
- 1h 37m
- Frequency
- Once daily
- Estimated price
- €90–110
- Website
- https://urlaubs-express.de/?lang=en
- Phone
- +39 800 142 424
- numeroverdetpl@regione.toscana.it
- Website
- at-bus.it
Bus from Siena-Via Tozzi to Firenze Autostazione
- Ave. Duration
- 1h 15m
- Frequency
- Hourly
- Estimated price
- €4–6
- Website
- https://www.at-bus.it/en
- Schedules at
- https://www.at-bus.it/en/lines-and-timetables
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Siena to Florence Villa Constanza Bus Station
- Ave. Duration
- 50 min
- Frequency
- Every 2 hours
- Estimated price
- €4–8
- Website
- https://www.flixbus.co.uk
Bus from Florence Villa Constanza Bus Station to Frankfurt central train station
- Ave. Duration
- 17h 30m
- Frequency
- Twice daily
- Estimated price
- €65–120
- Website
- https://www.flixbus.co.uk
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