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How to get fromSiena to Mainzby train, plane, train (Trenitalia), bus, or car

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There are 7 ways to get from Siena to Mainz by train, plane, train (Trenitalia), bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Florence Peretola Airport, fly

    best
    1. Take the train from Siena to Firenze S.M.N.train train
    2. Fly from Florence Peretola Airport (FLR) to Frankfurt (FRA)plane plane FLR - FRA
    6h 20m
    €139–314

  2. Bus via Frankfurt am Main

    cheapest
    1. Take the bus from Siena to Florence Villa Constanza Bus Stationbus bus 1509 / ...
    2. Take the bus from Florence Villa Constanza Bus Station to Frankfurt central train stationbus bus N77 / ...
    20h 13m
    €92–165

  3. Train

    1. Take the train from Siena to Firenze S.M.N.train train Re
    2. Take the train from Firenze S.M.N. to Milano Centraletrain train Fr
    3. Take the train from Milano Centrale to Mannheim Hbftrain train Ec
    4. Take the train from Mannheim, Hauptbahnhof to Mainz, Hauptbahnhoftrain train 55 / ...
    12h 47m
    €175–339

  4. Bus

    1. Take the bus from Siena to Florence Villa Constanza Bus Stationbus bus 1509 / ...
    2. Take the bus from Florence Villa Constanza Bus Station to Wiesbaden Gartenfeldstraße P+Rbus bus
    17h 31m

  5. Drive 1,023.7 km

    1. Drive from Siena to Mainzcar car 1,023.7 km
    9h 49m
    €162–234

  6. Train, train to Pisa International Airport, fly

    1. Take the train from Siena to Empolitrain train
    2. Take the train from Empoli to Pisa Centraletrain train
    3. Fly from Pisa International Airport (PSA) to Frankfurt (FRA)plane plane PSA - FRA
    6h 26m
    €123–263

  7. Train, train to Bologna Guglielmo Marconi Airport, fly

    1. Take the train from Siena to Firenze S.M.N.train train
    2. Take the train from Firenze S.M.N. to Bologna Centraletrain train
    3. Fly from Bologna Guglielmo Marconi Airport (BLQ) to Frankfurt (FRA)plane plane BLQ - FRA
    6h 47m
    €121–332

Siena to Mainz by train

Calendar7Weekly Trains
Duration12h 47mAverage Duration
Ticket€175Cheapest Price
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Questions & Answers

Map of how to get from Siena to Mainz.ExpandLaunch map view
  • Distance: 847.3 km
  • Duration: 6h 20m

What companies run services between Siena, Italy and Mainz, Germany?

You can take a train from Siena to Mainz, Hauptbahnhof via Firenze S.M.N., Milano Centrale, Mannheim Hbf, and Mannheim, Hauptbahnhof in around 12h 47m. Alternatively, you can take a bus from Siena to Mainz, Münsterplatz via Florence Villa Constanza Bus Station, Wiesbaden Gartenfeldstraße P+R, and Wiesbaden Hauptbahnhof in around 17h 31m.

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