There are 7 ways to get from Siena to Mainz by car, plane, bus, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Drive to Pisa International Airport, fly
best- Drive from Siena to Pisa International Airport (PSA)car
- Fly from Pisa International Airport (PSA) to Frankfurt (FRA)plane PSA - FRA
4h 3m€134–318Bus
cheapest- Take the bus from Siena to Bolognabus Siena
- Take the bus from Bologna Centrale to Frankfurt central train stationbus N422 / ...
18h 10m€77–144Bus, train via Mannheim
- Take the bus from Siena-Via Tozzi to Firenze Autostazionebus 131
- Take the train from Firenze S.M.N. to Milano Centraletrain Fr
- Take the train from Milano Centrale to Mannheim Hbftrain Ec
- Take the train from Mannheim, Hauptbahnhof to Mainz, Römisches Theatertrain S5 / ...
13h 19m€169–303Drive 1,023.7 km
- Drive from Siena to Mainzcar 1,023.7 km
9h 49m€159–229Bus to Florence Peretola Airport, fly
- Take the bus from Siena-Via Tozzi to Firenze Autostazionebus
- Fly from Florence Peretola Airport (FLR) to Frankfurt (FRA)plane FLR - FRA
5h 56m€114–351Bus, train to Bologna Guglielmo Marconi Airport, fly
- Take the bus from Siena-Via Tozzi to Firenze Autostazionebus
- Take the train from Firenze S.M.N. to Bologna Centraletrain
- Fly from Bologna Guglielmo Marconi Airport (BLQ) to Frankfurt (FRA)plane BLQ - FRA
6h 27m€121–359Bus, train
- Take the bus from Siena to Comobus Siena
- Take the train from Como S. Giovanni to Frankfurttrain Ec
15h 32m€242–707
Siena to Mainz by bus and train
Questions & Answers
The cheapest way to get from Siena to Mainz is to bus which costs €75 - €150 and takes 18h 10m.
The fastest way to get from Siena to Mainz is to drive and fly which takes 4h 3m and costs €130 - €320.
No, there is no direct bus from Siena to Mainz station. However, there are services departing from Siena and arriving at Mainz central train station via Bologna Centrale and Frankfurt central train station. The journey, including transfers, takes approximately 18h 10m.
The distance between Siena and Mainz is 857 km. The road distance is 1023.7 km.
The best way to get from Siena to Mainz without a car is to bus and train via Mannheim which takes 13h 19m and costs €160 - €310.
It takes approximately 4h 3m to get from Siena to Mainz, including transfers.
Siena to Mainz bus services, operated by Itabus S.p.A., depart from Siena station.
Siena to Mainz bus services, operated by Itabus S.p.A., arrive at Bologna station.
Yes, the driving distance between Siena to Mainz is 1024 km. It takes approximately 9h 49m to drive from Siena to Mainz.
Book your Siena to Mainz bus tickets online with FlixBus.
What companies run services between Siena, Italy and Mainz, Germany?
You can take a bus from Siena to Mainz central train station via Bologna Centrale and Frankfurt central train station in around 18h 10m.
- Website
- lufthansa.com
Flights from Pisa International Airport to Frankfurt
- Ave. Duration
- 1h 40m
- When
- Every day
- Estimated price
- €130–470
Flights from Florence Peretola Airport to Frankfurt
- Ave. Duration
- 1h 40m
- When
- Every day
- Estimated price
- €100–400
Flights from Florence Peretola Airport to Frankfurt via Munich
- Ave. Duration
- 3h 12m
- When
- Every day
- Estimated price
- €130–400
Flights from Bologna Guglielmo Marconi Airport to Frankfurt
- Ave. Duration
- 1h 34m
- When
- Every day
- Estimated price
- €90–420
Flights from Bologna Guglielmo Marconi Airport to Frankfurt via Munich
- Ave. Duration
- 3h 31m
- When
- Every day
- Estimated price
- €120–440
- Website
- airdolomiti.it
Flights from Pisa International Airport to Frankfurt
- Ave. Duration
- 1h 40m
- When
- Every day
- Estimated price
- €130–470
Flights from Florence Peretola Airport to Frankfurt
- Ave. Duration
- 1h 40m
- When
- Every day
- Estimated price
- €130–400
Flights from Bologna Guglielmo Marconi Airport to Frankfurt
- Ave. Duration
- 1h 30m
- When
- Every day
- Estimated price
- €110–420
- Website
- swiss.com
Flights from Florence Peretola Airport to Frankfurt via Zurich
- Ave. Duration
- 3h 20m
- When
- Every day
- Estimated price
- €120–210
Flights from Bologna Guglielmo Marconi Airport to Frankfurt via Zurich
- Ave. Duration
- 3h 45m
- When
- Monday, Wednesday, Friday, and Saturday
- Estimated price
- €75–310
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Firenze S.M.N. to Milano Centrale
- Ave. Duration
- 1h 55m
- Frequency
- Hourly
- Estimated price
- €45–90
- Schedules at
- trenitalia.com
Train from Firenze S.M.N. to Bologna Centrale
- Ave. Duration
- 37 min
- Frequency
- Every 30 minutes
- Estimated price
- €13–26
- Schedules at
- trenitalia.com
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Firenze S.M.N. to Milano Centrale
- Ave. Duration
- 3h 54m
- Frequency
- Once daily
- Estimated price
- €30–70
- Website
- https://www.trenitalia.com/en.html
Train from Firenze S.M.N. to Bologna Centrale
- Ave. Duration
- 1h 17m
- Frequency
- Once daily
- Estimated price
- €9–21
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- ufficiogruppi@trenitalia.it
- Website
- trenitalia.com
Train from Milano Centrale to Mannheim Hbf
- Ave. Duration
- 6h 48m
- Frequency
- Once daily
- Estimated price
- €120–180
- Website
- https://www.trenitalia.com/en.html
- 1st Class
- €120–180
- 2nd Class
- €120–160
Train from Firenze S.M.N. to Bologna Centrale
- Ave. Duration
- 1h 12m
- Frequency
- Once daily
- Estimated price
- €27–70
- Website
- https://www.trenitalia.com/en.html
- 1st Class
- €45–70
- 2nd Class
- €27–40
- Phone
- +49 30 2970
- Website
- bahn.de
Train from Mannheim, Hauptbahnhof to Mainz, Römisches Theater
- Ave. Duration
- 1h 17m
- Frequency
- Hourly
- Estimated price
- €19–27
- Website
- https://int.bahn.de/en
- Phone
- 0621 8301200
- Website
- suewex.de
Train from Mannheim, Hauptbahnhof to Mainz, Römisches Theater
- Ave. Duration
- 57 min
- Frequency
- 5 times a week
- Estimated price
- €14–20
- Schedules at
- suewex.de
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Firenze S.M.N. to Bologna Centrale
- Ave. Duration
- 1h 28m
- Frequency
- Twice daily
- Estimated price
- €11–19
- Website
- https://www.trenitalia.com/en.html
- Phone
- +41 848 446 688
- Website
- sbb.ch
Train from Como S. Giovanni to Frankfurt
- Ave. Duration
- 6h 53m
- Frequency
- Once a week
- Estimated price
- €210–650
- Website
- https://www.sbb.ch/en
- Phone
- +39 800 142 424
- numeroverdetpl@regione.toscana.it
- Website
- at-bus.it
Bus from Siena-Via Tozzi to Firenze Autostazione
- Ave. Duration
- 1h 15m
- Frequency
- Hourly
- Estimated price
- €4–6
- Website
- https://www.at-bus.it/en
- Schedules at
- https://www.at-bus.it/en/lines-and-timetables
- Phone
- +39 06 88 93 82 32
- Website
- itabus.it
Bus from Siena to Bologna
- Ave. Duration
- 2h 20m
- Frequency
- Hourly
- Estimated price
- €9–17
- Website
- https://www.itabus.it/en/home
Bus from Siena to Como
- Ave. Duration
- 6h 50m
- Frequency
- Once daily
- Estimated price
- €24–45
- Website
- https://www.itabus.it/en/home
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Siena to Bologna
- Ave. Duration
- 2h 35m
- Frequency
- Twice daily
- Estimated price
- €11–20
- Website
- https://www.flixbus.co.uk
Bus from Bologna Centrale to Frankfurt central train station
- Ave. Duration
- 13h 10m
- Frequency
- 3 times a day
- Estimated price
- €65–120
- Website
- https://www.flixbus.co.uk
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