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How to get fromSiena to Madridby train, plane, train (Renfe, Ouigo), bus, car or train (Trenitalia, Renfe)

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There are 8 ways to get from Siena to Madrid by train, plane, train (Renfe, Ouigo), bus, car, or train (Trenitalia, Renfe)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Florence Peretola Airport, fly

    best
    1. Take the train from Siena to Firenze S.M.N.train
    2. Fly from Florence Peretola Airport (FLR) to Adolfo Suárez Madrid–Barajas Airport (MAD)planeFLR - MAD
    6h 47m
    €62–195
  2. Train via Barcelona

    1. Take the train from Siena to Firenze S.M.N.trainRe
    2. Take the train from Florence Santa Maria Novella to Milano Centraletrain
    3. Take the train from Milano Centrale to Lyon Part DieutrainFr
    4. Take the train from Lyon Part Dieu to Barcelona-Santstrain
    5. Take the train from Barcelona-Sants to Madrid-Puerta de Atocha-Almudena GrandestrainAve
    18h 46m
    €168–465
  3. Bus

    1. Take the bus from Siena to Florence Villa Constanza Bus Stationbus443 / ...
    2. Take the bus from Florence Villa Constanza Bus Station to Genoabus510 / ...
    3. Take the bus from Genoa to Madridbus
    26h 30m
    €95–263
  4. Drive 1,674.9 km

    1. Drive from Siena to Madridcar1,674.9 km
    17h 9m
    €260–375
  5. Train, train to Pisa International Airport, fly

    1. Take the train from Siena to Empolitrain
    2. Take the train from Empoli to Pisa Centraletrain
    3. Fly from Pisa International Airport (PSA) to Adolfo Suárez Madrid–Barajas Airport (MAD)planePSA - MAD
    6h 45m
    €72–213
  6. Train, train to Bologna Guglielmo Marconi Airport, fly

    1. Take the train from Siena to Firenze S.M.N.train
    2. Take the train from Firenze S.M.N. to Bologna Centraletrain
    3. Fly from Bologna Guglielmo Marconi Airport (BLQ) to Adolfo Suárez Madrid–Barajas Airport (MAD)planeBLQ - MAD
    7h 25m
    €73–262
  7. Train

    1. Take the train from Siena to EmpolitrainRe
    2. Take the train from Empoli to Pisa CentraletrainRe
    3. Take the train from Pisa Centrale to VentimigliatrainIc
    4. Take the train from Ventimiglia to Marseille St Charlestrain
    5. Take the train from Marseille St Charles to Madrid-Puerta de Atocha-Almudena Grandestrain
    21h 18m
    €143–213
  8. Bus, train

    1. Take the bus from Siena-Via Tozzi to Firenze Autostazionebus131
    2. Take the train from Florence Santa Maria Novella to Torino - Porta Nuovatrain
    3. Take the bus from Turin Corso Vittorio Emanuele II to Madrid Mendez Alvaro Estacion Surbus
    30h 32m

Siena to Madrid by train

Calendar7Weekly Trains
Duration18h 46mAverage Duration
Ticket€168Cheapest Price
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Questions & Answers

What companies run services between Siena, Italy and Madrid, Spain?

You can take a train from Siena to Madrid-Puerta de Atocha-Almudena Grandes via Florence Santa Maria Novella, Milano Centrale, Lyon Part Dieu, and Barcelona-Sants in around 18h 46m. Alternatively, you can take a bus from Siena to Madrid via Florence Villa Constanza Bus Station and Genoa in around 26h 30m.

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