There are 8 ways to get from Siena to Lucerne by bus, train (Trenitalia), car, train, or plane
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus via Luzerner Raststätte A2
best- Take the bus from Siena to Florence Villa Constanza Bus Stationbus 1509 / ...
- Take the bus from Florence Villa Constanza Bus Station to Luzerner Raststätte A2bus
6h 43mBus
cheapest- Take the bus from Siena to Florence Villa Constanza Bus Stationbus 1509 / ...
- Take the bus from Florence to Luzernbus FlixBus 1524
11h 30mCHF 45–79Train via Milan
- Take the train from Siena to Firenze S.M.N.train Re
- Take the train from Firenze S.M.N. to Bologna Centraletrain Fr
- Take the train from Bologna centrale to Milano Centraletrain
- Take the train from Milano Centrale to Arth-Goldautrain Ec
7h 58mCHF 99–249Drive 604.2 km
- Drive from Siena to Lucernecar 604.2 km
6h 15mCHF 99–143Train to Florence Peretola Airport, fly to Zurich Airport, train
- Take the train from Siena to Firenze S.M.N.train
- Fly from Florence Peretola Airport (FLR) to Zurich Airport (ZRH)plane FLR - ZRH
- Take the train from Zürich HB to Luzerntrain
6h 25mCHF 129–315Train (Trenitalia)
- Take the train from Siena to Firenze S.M.N.train Re / ...
- Take the train from Firenze S.M.N. to Arth-Goldautrain Ec
10h 10mCHF 119–204Train, train to Bologna Guglielmo Marconi Airport, fly to Zurich Airport
- Take the train from Siena to Firenze S.M.N.train
- Take the train from Firenze S.M.N. to Bologna Centraletrain
- Fly from Bologna Guglielmo Marconi Airport (BLQ) to Zurich Airport (ZRH)plane BLQ - ZRH
- Take the train from Zürich HB to Luzerntrain
7h 4mCHF 121–368Train to Florence Peretola Airport, fly to Basel, train
- Take the train from Siena to Firenze S.M.N.train
- Fly from Florence Peretola Airport (FLR) to Basel (BSL)plane FLR - BSL
- Take the train from Basel SBB to Luzerntrain
9h 30mCHF 134–296
Siena to Lucerne by train (Trenitalia)
Questions & Answers
The cheapest way to get from Siena to Lucerne is to bus which costs SFr 40 - SFr 80 and takes 11h 30m.
The fastest way to get from Siena to Lucerne is to drive which takes 6h 15m and costs SFr 95 - SFr 150.
No, there is no direct bus from Siena to Lucerne. However, there are services departing from Siena and arriving at Luzerner Raststätte A2 via Florence Villa Constanza Bus Station. The journey, including transfers, takes approximately 6h 43m.
No, there is no direct train from Siena to Lucerne. However, there are services departing from Siena and arriving at Luzern via Firenze S.M.N., Bologna centrale, Milano Centrale and Arth-Goldau. The journey, including transfers, takes approximately 7h 58m.
The distance between Siena and Lucerne is 652 km. The road distance is 604.2 km.
The best way to get from Siena to Lucerne without a car is to bus via Luzerner Raststätte A2 which takes 6h 43m and costs .
It takes approximately 6h 43m to get from Siena to Lucerne, including transfers.
Siena to Lucerne bus services, operated by FlixBus, depart from Siena station.
Siena to Lucerne train services, operated by Trenitalia, depart from Siena station.
The best way to get from Siena to Lucerne is to bus via Luzerner Raststätte A2 which takes 6h 43m and costs . Alternatively, you can train via Milan, which costs SFr 95 - SFr 250 and takes 7h 58m.
What companies run services between Siena, Italy and Lucerne, Switzerland?
You can take a bus from Siena to Lucerne via Florence Villa Constanza Bus Station and Luzerner Raststätte A2 in around 6h 43m. Alternatively, you can take a train from Siena to Luzern via Firenze S.M.N., Bologna centrale, Milano Centrale, and Arth-Goldau in around 7h 58m.
- Website
- swiss.com
Flights from Florence Peretola Airport to Zurich Airport
- Ave. Duration
- 1h 18m
- When
- Every day
- Estimated price
- CHF 90–240
Flights from Bologna Guglielmo Marconi Airport to Zurich Airport
- Ave. Duration
- 1h 16m
- When
- Every day
- Estimated price
- CHF 80–260
- Website
- lufthansa.com
Flights from Florence Peretola Airport to Basel via Frankfurt
- Ave. Duration
- 3h 33m
- When
- Every day
- Estimated price
- CHF 170–700
Flights from Florence Peretola Airport to Basel via Munich
- Ave. Duration
- 5h 20m
- When
- Wednesday to Sunday
- Estimated price
- CHF 170–650
- Website
- airdolomiti.it
Flights from Florence Peretola Airport to Basel via Frankfurt
- Ave. Duration
- 3h 30m
- When
- Monday, Saturday, and Sunday
- Estimated price
- CHF 170–700
Flights from Florence Peretola Airport to Basel via Munich
- Ave. Duration
- 6h 30m
- When
- Sunday
- Estimated price
- CHF 170–650
- Website
- airfrance.com
Flights from Florence Peretola Airport to Basel via Paris Charles de Gaulle
- Ave. Duration
- 3h 55m
- When
- Monday, Tuesday, Wednesday, Thursday, Saturday, and Sunday
- Estimated price
- CHF 75–380
- Website
- austrian.com
Flights from Florence Peretola Airport to Basel via Vienna
- Ave. Duration
- 5h
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- CHF 100–380
- Phone
- +39.06.5210550
- Website
- Trenitalia
Train from Siena to Firenze S.M.N.
- Ave. Duration
- 1h 34m
- Frequency
- Hourly
- Estimated price
- CHF 11–18
- Website
- Trenitalia
Train from Firenze S.M.N. to Bologna Centrale
- Ave. Duration
- 1h 28m
- Frequency
- Twice daily
- Estimated price
- CHF 10–18
- Website
- Trenitalia
Train from Siena to Firenze S.M.N.
- Ave. Duration
- 1h 34m
- Frequency
- Hourly
- Estimated price
- CHF 11–18
- Website
- Trenitalia
Train from Siena to Firenze S.M.N.
- Ave. Duration
- 1h 34m
- Frequency
- Hourly
- Estimated price
- CHF 11–18
- Website
- Trenitalia
Train from Siena to Firenze S.M.N.
- Ave. Duration
- 1h 34m
- Frequency
- Hourly
- Estimated price
- CHF 11–18
- Website
- Trenitalia
Train from Firenze S.M.N. to Bologna Centrale
- Ave. Duration
- 1h 28m
- Frequency
- Twice daily
- Estimated price
- CHF 10–18
- Website
- Trenitalia
Train from Siena to Firenze S.M.N.
- Ave. Duration
- 1h 34m
- Frequency
- Hourly
- Estimated price
- CHF 11–18
- Website
- Trenitalia
- Phone
- +39 06 68475475
- Website
- Trenitalia Frecce
Train from Firenze S.M.N. to Bologna Centrale
- Ave. Duration
- 37 min
- Frequency
- Every 30 minutes
- Estimated price
- CHF 12–25
- Schedules at
- Trenitalia Frecce
Train from Firenze S.M.N. to Bologna Centrale
- Ave. Duration
- 37 min
- Frequency
- Every 30 minutes
- Estimated price
- CHF 12–25
- Schedules at
- Trenitalia Frecce
- Phone
- +39 06 8937 1892
- Website
- Italo Treno
Train from Firenze S.M.N. to Bologna Centrale
- Ave. Duration
- 45 min
- Frequency
- 4 times a day
- Estimated price
- CHF 11–22
- Website
- Italo Treno
Train from Bologna centrale to Milano Centrale
- Ave. Duration
- 1h 4m
- Frequency
- Every 30 minutes
- Estimated price
- CHF 26–50
- Website
- Italo Treno
Train from Firenze S.M.N. to Bologna Centrale
- Ave. Duration
- 45 min
- Frequency
- 4 times a day
- Estimated price
- CHF 11–22
- Website
- Italo Treno
- Phone
- +39 06 68475475
- Website
- Trenitalia Intercity
Train from Firenze S.M.N. to Bologna Centrale
- Ave. Duration
- 1h 17m
- Frequency
- Once daily
- Estimated price
- CHF 9–19
- Website
- Trenitalia Intercity
Train from Firenze S.M.N. to Bologna Centrale
- Ave. Duration
- 1h 17m
- Frequency
- Once daily
- Estimated price
- CHF 9–19
- Website
- Trenitalia Intercity
- Phone
- +39 06 68475475
- ufficiogruppi@trenitalia.it
- Website
- Trenitalia Eurocity
Train from Firenze S.M.N. to Bologna Centrale
- Ave. Duration
- 1h 12m
- Frequency
- Once daily
- Estimated price
- CHF 25–65
- Website
- Trenitalia Eurocity
- 1st Class
- CHF 45–65
- 2nd Class
- CHF 25–35
Train from Milano Centrale to Arth-Goldau
- Ave. Duration
- 2h 32m
- Frequency
- Hourly
- Estimated price
- CHF 45–90
- Website
- Trenitalia Eurocity
- 1st Class
- CHF 60–90
- 2nd Class
- CHF 45–65
Train from Firenze S.M.N. to Arth-Goldau
- Ave. Duration
- 6h 52m
- Frequency
- Once daily
- Estimated price
- CHF 100–160
- Website
- Trenitalia Eurocity
- 1st Class
- CHF 100–160
- 2nd Class
- CHF 100–140
Train from Firenze S.M.N. to Bologna Centrale
- Ave. Duration
- 1h 12m
- Frequency
- Once daily
- Estimated price
- CHF 25–65
- Website
- Trenitalia Eurocity
- 1st Class
- CHF 45–65
- 2nd Class
- CHF 25–35
Train from Zürich HB to Luzern
- Ave. Duration
- 41 min
- Frequency
- Every 30 minutes
- Estimated price
- CHF 18–55
- Website
- Swiss Federal Railways (SBB CFF FFS)
Train from Zürich HB to Luzern
- Ave. Duration
- 41 min
- Frequency
- Every 30 minutes
- Estimated price
- CHF 18–55
- Website
- Swiss Federal Railways (SBB CFF FFS)
Train from Basel SBB to Luzern
- Ave. Duration
- 1h 1m
- Frequency
- Every 2 hours
- Estimated price
- CHF 30–95
- Website
- Swiss Federal Railways (SBB CFF FFS)
- Phone
- +41 58 580 70 70
- Website
- Schweizerische Südostbahn AG
Train from Basel SBB to Luzern
- Ave. Duration
- 1h 1m
- Frequency
- Every 4 hours
- Estimated price
- CHF 30–45
- Schedules at
- Schweizerische Südostbahn AG
Rome2Rio's guide to FlixBus
Contact DetailsContact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- Flixbus
Bus from Siena to Florence Villa Constanza Bus Station
- Ave. Duration
- 50 min
- Frequency
- Every 3 hours
- Estimated price
- CHF 4–8
- Website
- Flixbus
Bus from Siena to Florence Villa Constanza Bus Station
- Ave. Duration
- 50 min
- Frequency
- Every 3 hours
- Estimated price
- CHF 4–8
- Website
- Flixbus
Bus from Florence to Luzern
- Ave. Duration
- 9h 40m
- Frequency
- Twice daily
- Estimated price
- CHF 40–70
- Website
- Flixbus
- Phone
- +3 318 576 2228
- Website
- BlaBlaCar Bus
Bus from Siena to Florence Villa Constanza Bus Station
- Ave. Duration
- 1h
- Frequency
- Twice a week
- Estimated price
- CHF 5–10
- Website
- BlaBlaCar Bus
Bus from Siena to Florence Villa Constanza Bus Station
- Ave. Duration
- 1h
- Frequency
- Twice a week
- Estimated price
- CHF 5–10
- Website
- BlaBlaCar Bus
- Phone
- +39 0362 185 0590
- info@onebus.it
- Website
- Onebus
Bus from Florence Villa Constanza Bus Station to Luzerner Raststätte A2
- Ave. Duration
- 4h 41m
- Frequency
- Once a week
- Website
- Onebus
Want to know more about travelling around Switzerland
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More Questions & Answers
Siena to Lucerne bus services, operated by FlixBus, arrive at Florence Villa Constanza Bus Station.
Siena to Lucerne train services, operated by Trenitalia, arrive at Firenze S.M.N. station.
Yes, the driving distance between Siena to Lucerne is 604 km. It takes approximately 6h 15m to drive from Siena to Lucerne.
Book your Siena to Lucerne train tickets online with Omio.
Book your Siena to Lucerne bus tickets online with Omio.
There are 681+ hotels available in Lucerne.







































