Cambodia Angkor Air, Vietnam Airlines and Lanmei Airlines fly from Siem Reap to Ho Chi Minh City every 4 hours. Alternatively, Virak Buntham operates a bus from Siem Reap to Ho Chi Minh City every 4 hours. Tickets cost $22 and the journey takes 12 h. Mekong Express also services this route once daily.
From Siem Reap taxi to Siem Reap airport then fly to Ho Chi Minh City airport. 1 h 12 min $152. From Siem Reap Virak Buntham Express bus to Ho Chi Minh Virak Buntham Express. 12 h $26. From Siem Reap bus to Phnom Penh Cambodia then bus to Ho Chi Minh. 14 h $17. From Siem Reap drive to Ho Chi Minh City. 7 h 2 min $43.