There are 8 ways to get from Sicily to Santander by plane, car ferry, car, bus, or train (Trenitalia, Renfe)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Catania–Fontanarossa Airport to Santander Airport
best- Fly from Catania–Fontanarossa Airport (CTA) to Santander Airport (SDR)CTA - SDR
7h 16m€67–263Car ferry, drive
- Take the car ferry from Port of Palermo to Port of Genoa
- Drive from Port of Genoa to Santander
33h 9m€261–411Bus via Bordeaux
- Take the bus from Palermo to Florence Villa Constanza Bus Station
- Take the bus from Florence Villa Constanza Bus Station to Bordeaux
- Take the bus from Bordeaux to Santander
43h 58m€123–341Train
- Take the train from Palermo Centrale to Roma TerminiIc
- Take the train from Roma Termini to Marseille St Charles
- Take the train from Marseille St Charles to Madrid-Puerta de Atocha-Almudena Grandes
- Take the train from Madrid Chamartín to SantanderAlv / ...
44h 21m€215–411Fly Palermo Airport to Santander Airport
- Fly from Palermo Airport (PMO) to Santander Airport (SDR)PMO - SDR
9h 24m€94–315Fly Catania–Fontanarossa Airport to Bilbao Airport, bus
- Fly from Catania–Fontanarossa Airport (CTA) to Bilbao Airport (BIO)CTA - BIO
- Take the bus from Bilbao Intermodal to Santander E.A.
10h 27m€81–251Car ferry, bus
- Take the car ferry from Port of Palermo to Port of Genoa
- Take the bus from Genoa to Nice Airport798 / ...
- Take the bus from Nice Airport to Bilbao
- Take the bus from Bilbao Intermodal to Santander E.A.
46h 20m€134–306Bus
- Take the bus from Palermo Via Tommaso Fazello to Milano, San Donato M3
- Take the bus from Milano, Autostazione Lampugnano to Vitoria Gasteiz Central Bus Station
- Take the bus from Vitoria-Gasteiz to Santander E.A.
2d 1h€125–190
Sicily to Santander by bus
Questions & Answers
The cheapest way to get from Sicily to Santander is to fly and bus which costs €80 - €260 and takes 10h 27m.
The fastest way to get from Sicily to Santander is to fly which takes 7h 16m and costs €65 - €270.
No, there is no direct bus from Sicily to Santander. However, there are services departing from Piazza Boiardo and arriving at Santander via Palermo, Florence Villa Constanza Bus Station and Bordeaux. The journey, including transfers, takes approximately 43h 58m.
No, there is no direct train from Sicily to Santander. However, there are services departing from Palermo Notarbartolo and arriving at Santander via Palermo Centrale, Roma Termini, Marseille St Charles, Madrid-Atocha Cercanías and Madrid Chamartín. The journey, including transfers, takes approximately 44h 21m.
The distance between Sicily and Santander is 1729 km.
The best way to get from Sicily to Santander without a car is to bus via Bordeaux which takes 43h 58m and costs €120 - €350.
It takes approximately 7h 16m to get from Sicily to Santander, including transfers.
Sicily to Santander bus services, operated by FlixBus, depart from Palermo station.
Sicily to Santander train services, operated by Trenitalia Intercity, depart from Palermo Centrale station.
The best way to get from Sicily to Santander is to fly which takes 7h 16m and costs €65 - €270. Alternatively, you can bus via Bordeaux, which costs €120 - €350 and takes 43h 58m, you could also train, which costs €210 - €420 and takes 44h 21m.
What companies run services between Sicily, Italy and Santander, Spain?
Iberia, Vueling Airlines, and Ryanair fly from Catania–Fontanarossa Airport (CTA) to Santander Airport (SDR) twice daily. Alternatively, you can take a bus from Piazza Boiardo to Santander via Stazione Centrale Pensilina Esterna, Palermo, Florence Villa Constanza Bus Station, and Bordeaux in around 43h 58m.
- Website
- iberia.com
Flights from Catania–Fontanarossa Airport to Santander Airport via Madrid
- Ave. Duration
- 7h 10m
- When
- Tuesday, Wednesday, Thursday, Saturday, and Sunday
- Estimated price
- €85–310
Flights from Catania–Fontanarossa Airport to Santander Airport via Barcelona
- Ave. Duration
- 6h 5m
- When
- Tuesday, Thursday, Friday, and Sunday
- Estimated price
- €65–260
Flights from Palermo Airport to Santander Airport via Madrid
- Ave. Duration
- 10h 50m
- When
- Monday, Thursday, and Sunday
- Estimated price
- €95–350
Flights from Palermo Airport to Santander Airport via Barcelona
- Ave. Duration
- 6h 40m
- When
- Tuesday, Friday, and Sunday
- Estimated price
- €90–310
Flights from Catania–Fontanarossa Airport to Bilbao Airport via Barcelona
- Ave. Duration
- 5h 25m
- When
- Sunday
- Estimated price
- €70–150
- Website
- vueling.com
Flights from Catania–Fontanarossa Airport to Santander Airport via Barcelona
- Ave. Duration
- 6h 5m
- When
- Tuesday, Thursday, Friday, and Sunday
- Estimated price
- €65–260
Flights from Palermo Airport to Santander Airport via Barcelona
- Ave. Duration
- 6h 40m
- When
- Tuesday, Friday, and Sunday
- Estimated price
- €90–310
Flights from Palermo Airport to Santander Airport via Madrid
- Ave. Duration
- 11h 55m
- When
- Thursday and Sunday
- Estimated price
- €95–320
Flights from Catania–Fontanarossa Airport to Bilbao Airport via Barcelona
- Ave. Duration
- 5h 25m
- When
- Sunday
- Estimated price
- €70–150
Flights from Catania–Fontanarossa Airport to Bilbao Airport via Rome
- Ave. Duration
- 6h 50m
- When
- Wednesday
- Estimated price
- €70–150
- Website
- ryanair.com
Flights from Catania–Fontanarossa Airport to Santander Airport via Bologna
- Ave. Duration
- 8h 15m
- When
- Sunday
- Estimated price
- €85–290
Flights from Catania–Fontanarossa Airport to Santander Airport via Charleroi
- Ave. Duration
- 10h 55m
- When
- Monday and Saturday
- Estimated price
- €100–310
Flights from Palermo Airport to Santander Airport via Charleroi
- Ave. Duration
- 11h 10m
- When
- Saturday
- Estimated price
- €110–350
- Website
- volotea.com
Flights from Catania–Fontanarossa Airport to Bilbao Airport via Rome
- Ave. Duration
- 5h 15m
- When
- Monday and Friday
- Estimated price
- €65–240
- Website
- flyulendo.com
Flights from Catania–Fontanarossa Airport to Bilbao Airport via Rome
- Ave. Duration
- 6h 20m
- When
- Monday and Friday
- Estimated price
- €45–200
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Palermo Centrale to Roma Termini
- Ave. Duration
- 11h 29m
- Frequency
- Once daily
- Estimated price
- €35–110
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Roma Termini to Marseille St Charles
- Ave. Duration
- 16h 12m
- Frequency
- Once a week
- Estimated price
- €45–70
- Website
- https://www.trenitalia.com/en.html
- Phone
- +34 91 232 03 20
- Website
- renfe.com
Train from Marseille St Charles to Madrid-Puerta de Atocha-Almudena Grandes
- Ave. Duration
- 7h 48m
- Frequency
- Once daily
- Estimated price
- €90–130
- Website
- https://www.renfe.com/es/en
Train from Madrid Chamartín to Santander
- Ave. Duration
- 4h 20m
- Frequency
- Twice daily
- Estimated price
- €40–95
- Website
- https://www.renfe.com/es/en
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Palermo to Florence Villa Constanza Bus Station
- Ave. Duration
- 17h 20m
- Frequency
- Twice daily
- Estimated price
- €50–120
- Website
- https://www.flixbus.co.uk
Bus from Florence Villa Constanza Bus Station to Bordeaux
- Ave. Duration
- 17h 10m
- Frequency
- Once daily
- Estimated price
- €65–160
- Website
- https://www.flixbus.co.uk
Bus from Bordeaux to Santander
- Ave. Duration
- 6h 5m
- Frequency
- Once daily
- Estimated price
- €22–60
- Website
- https://www.flixbus.co.uk
Bus from Genoa to Nice Airport
- Ave. Duration
- 2h 45m
- Frequency
- Every 2 hours
- Estimated price
- €10–20
- Website
- https://www.flixbus.co.uk
Bus from Nice Airport to Bilbao
- Ave. Duration
- 16h 40m
- Frequency
- 3 times a week
- Estimated price
- €55–150
- Website
- https://www.flixbus.co.uk
- Phone
- (+39) 0923 98.11.20
- Website
- autoservizisalemi.it
Bus from Palermo to Florence Villa Constanza Bus Station
- Ave. Duration
- 15h
- Frequency
- Twice a week
- Estimated price
- €35–55
- Schedules at
- autoservizisalemi.it
Bus from Palermo Via Tommaso Fazello to Milano, San Donato M3
- Ave. Duration
- 19h 10m
- Frequency
- Once a week
- Estimated price
- €50–75
- Schedules at
- autoservizisalemi.it
- Phone
- +34 910 207 007
- alsa@alsa.es
- Website
- alsa.com
Bus from Bilbao Intermodal to Santander E.A.
- Ave. Duration
- 1h 40m
- Frequency
- Hourly
- Estimated price
- €8–15
- Website
- https://www.alsa.com/en/
Bus from Vitoria-Gasteiz to Santander E.A.
- Ave. Duration
- 2h 30m
- Frequency
- 5 times a day
- Estimated price
- €13
- Website
- https://www.alsa.com/en/
- Phone
- 07001 8282
- booking@union-ivkoni.com
- Website
- union-ivkoni.com
Bus from Milano, Autostazione Lampugnano to Vitoria Gasteiz Central Bus Station
- Ave. Duration
- 23h 30m
- Frequency
- Once a week
- Estimated price
- €60–95
- Website
- https://union-ivkoni.com/en
- Phone
- +39 010 209 4591
- booking@gnv.it
- Website
- gnv.it
Car ferry from Port of Palermo to Port of Genoa
- Ave. Duration
- 20h 45m
- Frequency
- Once daily
- Estimated price
- €60–120
- Website
- https://www.gnv.it/en
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More Questions & Answers
Sicily to Santander bus services, operated by FlixBus, arrive at Florence Villa Constanza Bus Station.
Sicily to Santander train services, operated by Trenitalia Intercity, arrive at Roma Termini station.
There are 1935+ hotels available in Santander.

































