Japan Railways Limited Express operates a train from Shinjuku to Shinano Ōmachi-eki 5 times a week. Tickets cost $55 - $70 and the journey takes 3 h 31 min. Alternatively, Access Shinshu operates a bus from Shinjuku to Shinano Ōmachi-eki 5 times a day. Tickets cost $43 and the journey takes 4 h 45 min.
From Shinjuku(Jr) train to Shinano-Omachi. 3 h 31 min ¥7017. From Bus terminal Shinjuku, Tokyo bus to Shinano-Omachi. 4 h 45 min ¥4850. From Higashi-Shinjuku subway to Buster Shinjuku, bus to Kami-Suwa, train to Matsumoto, then train to Shinano-Omachi. 7 h 15 min ¥5091. From Shinjuku drive to Shinano Ōmachi-eki. 3 h 20 min ¥3643.