Japan Railways Shinkansen operates a train from Shin-Yokohama Station to Shinjuku every 15 minutes. Tickets cost $14 - $21 and the journey takes 11 min. Japan Railways (JR) also services this route every 10 minutes.
How to get from Shin-Yokohama Station to Shinjuku
From Shin-Yokohama train to Shinagawa then train to Shinjuku(Jr). 33 min ¥2195. From Shin-Yokohama Station taxi to Shinjuku. 26 min ¥14144. From Shin-Yokohama Station drive to Shinjuku. 26 min ¥438.