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How to get fromSeffner to Chicagoby plane, bus (Greyhound, Flixbus), train (Amtrak), car, train or bus

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There are 7 ways to get from Seffner to Chicago by plane, bus (Greyhound, Flixbus), train (Amtrak), car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Tampa to Chicago Midway International Airport

    best
    1. Fly from Tampa (TPA) to Chicago Midway International Airport (MDW)plane plane TPA - MDW
    6h 6m
    $108–501
  2. Bus

    1. Take the bus from Tornado Bus Co - Plant City, FL to Circle K - Gainesville, FLbus bus
    2. Take the bus from Gainesville to Atlanta - Civic Center MARTA Stationbus bus
    3. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus
    27h 6m
    $304–629
  3. Train (Amtrak)

    1. Take the train from Tampa to Chicago Union Stationtrain train Floridian
    41h 17m
    $525–1,141
  4. Drive 1,128.1 mi

    1. Drive from Seffner to Chicagocar car 1,128.1 mi
    19h 47m
    $206–298
  5. Fly Tampa to Chicago O'Hare International Airport

    1. Fly from Tampa (TPA) to Chicago O'Hare International Airport (ORD)plane plane TPA - ORD
    6h 29m
    $128–461
  6. Fly Tampa to General Mitchell International Airport, train

    1. Fly from Tampa (TPA) to General Mitchell International Airport (MKE)plane plane TPA - MKE
    2. Take the train from Milwaukee to Chicago Union Stationtrain train
    8h 34m
    $201–925
  7. Bus to Sarasota–Bradenton International Airport, fly to Chicago Midway International Airport

    1. Take the bus from Tampa Bus Station to Sarasota Cattlemen Transfer Centerbus bus
    2. Fly from Sarasota–Bradenton International Airport (SRQ) to Chicago Midway International Airport (MDW)plane plane SRQ - MDW
    9h 4m
    $185–875

Tampa (TPA) to Chicago Midway International Airport (MDW) flights

Calendar53Weekly Planes
Duration4h 7mAverage Duration
Ticket$100Cheapest Price
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Questions & Answers

What companies run services between Seffner, FL, USA and Chicago, IL, USA?

Southwest Airlines flies from Tampa (TPA) to Chicago Midway International Airport (MDW) every 4 hours. Alternatively, you can take a vehicle from Seffner to Chicago Bus Station via Tornado Bus Co - Plant City, FL, Circle K - Gainesville, FL, Gainesville, Atlanta - Civic Center MARTA Station, Civic Center Station, Garnett Station, and Atlanta Bus Station in around 27h 6m.

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