Rome2Rio

How to get fromSeattle to St. Louis (Region)by plane, bus (Flixbus, Greyhound), train (Amtrak), car, shuttle or train

Find Transport to St. Louis (Region)

See all options

There are 7 ways to get from Seattle to St. Louis (Region) by plane, bus (Flixbus, Greyhound), train (Amtrak), car, shuttle, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Seattle-Tacoma International Airport

    best
    1. Fly from Seattle-Tacoma International Airport (SEA) to Lambert–St. Louis International Airport (STL)plane plane SEA - STL
    6h 27m
    $229–1,109

  2. Bus

    1. Take the bus from Seattle Greyhound to Spokanebus bus
    2. Take the bus from Spokane to Billingsbus bus
    3. Take the bus from Billings, MT to Cheyenne, WYbus bus
    4. Take the bus from Cheyenne to Denver Union Stationbus bus
    5. Take the bus from Denver Union Station to St Louis Bus Stationbus bus
    2d 1h
    $429–794

  3. Train (Amtrak)

    1. Take the train from Seattle to Chicago Union Stationtrain train Empire Builder
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    2d 3h
    $711–1,529

  4. Drive 2,078.8 mi

    1. Drive from Seattle to St. Louis (Region)car car 2,078.8 mi
    33h 3m
    $380–548

  5. Shuttle to Bellingham International Airport, fly

    1. Take a shuttle bus from Seattle, WA - Convention Center to Bellingham Airportshuttle bus
    2. Fly from Bellingham International Airport (BLI) to Lambert–St. Louis International Airport (STL)plane plane BLI - STL
    10h 20m
    $303–1,364

  6. Fly from Paine Field County Airport

    1. Fly from Paine Field County Airport (PAE) to Lambert–St. Louis International Airport (STL)plane plane PAE - STL
    10h 5m
    $330–1,529

  7. Train to Portland International Airport, fly

    1. Take the train from Seattle to Portlandtrain train
    2. Fly from Portland International Airport (PDX) to Lambert–St. Louis International Airport (STL)plane plane PDX - STL
    9h 44m
    $357–1,515

Seattle to St. Louis (Region) by bus

Calendar1Weekly Buses
Duration2d 1hAverage Duration
Ticket$429Cheapest Price
See schedules

Questions & Answers

What companies run services between Seattle, WA, USA and St. Louis (Region), MO, USA?

Alaska Airlines, Inc., Southwest Airlines, and two other airlines fly from Seattle-Tacoma International Airport (SEA) to Lambert–St. Louis International Airport (STL) every 2 hours. Alternatively, you can take a bus from Seattle Greyhound to St Louis Bus Station via Spokane, Billings, Billings, MT, Cheyenne, and Denver Union Station in around 2d 1h.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers

Trips from Seattle

Trips to St. Louis (Region)

Popular routes