Rome2Rio

How to get fromSeattle to St. Louisby plane, bus (Flixbus, Greyhound), train (Amtrak), car or bus

Find Transport to St. Louis

See all options

There are 5 ways to get from Seattle to St. Louis by plane, bus (Flixbus, Greyhound), train (Amtrak), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Seattle-Tacoma International Airport

    best
    1. Fly from Seattle-Tacoma International Airport (SEA) to Lambert–St. Louis International Airport (STL)plane plane SEA - STL
    6h 21m
    $199–859

  2. Bus

    1. Take the bus from Seattle Bus Station to Spokane Stationbus bus
    2. Take the bus from Spokane to Billingsbus bus
    3. Take the bus from Billings, MT to Cheyenne, WYbus bus
    4. Take the bus from Cheyenne to Denver Union Stationbus bus
    5. Take the bus from Denver Union Station to St Louis Bus Stationbus bus
    47h 5m
    $328–707

  3. Train (Amtrak)

    1. Take the train from Seattle to Chicago Union Stationtrain train Empire Builder
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    2d 3h
    $235–1,436

  4. Drive 2,078.8 mi

    1. Drive from Seattle to St. Louiscar car 2,078.8 mi
    33h 9m
    $380–548

  5. Bus to Bellingham International Airport, fly

    1. Take the bus from Seattle, WA - Convention centre to Bellingham Airportbus bus
    2. Fly from Bellingham International Airport (BLI) to Lambert–St. Louis International Airport (STL)plane plane BLI - STL
    10h 30m
    $243–989

Seattle to St. Louis by bus

Calendar1Weekly Buses
Duration47h 5mAverage Duration
Ticket$328Cheapest Price
See schedules

Questions & Answers

What companies run services between Seattle, WA, USA and St. Louis, MO, USA?

Alaska Airlines, Inc., Southwest Airlines, and two other airlines fly from Seattle-Tacoma International Airport (SEA) to Lambert–St. Louis International Airport (STL) every 3 hours. Alternatively, you can take a bus from Seattle Bus Station to St Louis Bus Station via Spokane, Billings, Billings, MT, Cheyenne, and Denver Union Station in around 47h 5m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers

Trips from Seattle

Trips to St. Louis

Popular routes