There are 5 ways to get from Santiago to Cusco by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly  •  6 h

  1. Fly from Santiago (SCL) to Cuzco (CUZ) SCL - CUZ

$192 - $846

Cheapest option

Bus, Tour  •  43 h 19 min

  1. Take the bus from Santiago to Tacna
  2. Take the bus from Tacna to Arequipa
  3. Take the Tour from Arequipa to Cusco

$161 - $282

3 alternative options

Bus, train  •  3 days 0 h

  1. Take the bus from Santiago to Tacna
  2. Take the bus from Tacna to Arequipa
  3. Take the train from Arequipa to Cusco - Wanchaq

$301 - $6,162

Bus  •  3 days 2 h

  1. Take the bus from Santiago to Mendoza
  2. Take the bus from Mendoza to Camaná
  3. Take the bus from Camaná to Chivay
  4. Take the bus from Chivay to Cusco

Drive  •  36 h 32 min

  1. Drive from Santiago to Cusco 1806.9 miles

$290 - $440

Questions & Answers

No, there is no direct bus from Santiago to Cusco. However, there are services departing from Santiago and arriving at Cusco via Tacna and Arequipa. The journey, including transfers, takes approximately 43 h 19 min.

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The distance between Santiago and Cusco is 2221 km. The road distance is 2891.1 km.

Get driving directions

The best way to get from Santiago to Cusco without a car is to bus and Tour which takes 43 h 19 min and costs .

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It takes approximately 6 h to get from Santiago to Cusco, including transfers.

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Santiago to Cusco bus services, operated by Expreso Internacional Ormeño, depart from Santiago station.

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The best way to get from Santiago to Cusco is to fly which takes 6 h and costs . Alternatively, you can bus and Tour, which costs and takes 43 h 19 min.

Mode details

The quickest flight from Santiago Airport to Cuzco Airport is the direct flight which takes 3 h 25 min.

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Santiago to Cusco bus services, operated by Peru Hop, arrive at Cusco station.

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Cusco is 1 h behind Santiago. It is currently 10:06 PM in Santiago and 8:06 PM in Cusco.

Yes, the driving distance between Santiago to Cusco is 2891 km. It takes approximately 36 h 32 min to drive from Santiago to Cusco.

Get driving directions

Map of how to get from Santiago to Cusco.
Launch map view
  • Distance: 1387.9 miles
  • Duration: 6 h

What companies run services between Santiago, Chile and Cusco, Peru?

LATAM Chile and Avianca - Aerovías del Continente Americano S.A. fly from Santiago to Cusco hourly. Alternatively, you can take a bus from Santiago to Cusco via Tacna and Arequipa in around 43 h 19 min.

Airlines
LATAM Chile
Website
latam.com
Flights from Santiago to Cuzco
Ave. Duration
3 h 25 min
When
Tuesday, Wednesday and Friday
Estimated price
$360 - $950
Flights from Santiago to Cuzco via Lima
Ave. Duration
6 h 15 min
When
Every day
Estimated price
$360 - $950
Avianca - Aerovías del Continente Americano S.A.
Website
avianca.com
Flights from Santiago to Cuzco via Lima
Ave. Duration
7 h 25 min
When
Every day
Estimated price
$220 - $1,300
Train operators
PeruRail
Phone
51-84-581414
Email
reservas@perurail.com
Website
perurail.com
Train from Arequipa to Cusco - Wanchaq
Ave. Duration
40 h 58 min
Frequency
Once a week
Estimated price
$210 - $6,000
Schedules at
perurail.com
Book at
pax1.perurail.com
VIP
$210 - $6,000
Regular
$600 - $850
Bus operators
Oltursa
Website
oltursa.pe
Bus from Tacna to Arequipa
Ave. Duration
5 h 30 min
Frequency
Once daily
Estimated price
$10 - $50
Schedules at
oltursa.pe
Book at
oltursa.pe
Double VIP
$30 - $50
Bed
$14 - $19
VIP
$21 - $30
Peru Hop
Phone
+51 1 2422140
Email
info@peruhop.com
Bus from Arequipa to Cusco
Ave. Duration
11 h 45 min
Frequency
Once daily
Estimated price
$70 - $120
Schedules at
peruhop.com
Book at
peruhop.com
Cata International
Cruz del Sur
Phone
+51 1 311-5050
Website
cruzdelsur.com.pe
Bus from Mendoza to Camaná
Ave. Duration
2 days 2 h
Frequency
Once a week
Estimated price
$140 - $200
Schedules at
cruzdelsur.com.pe
4M
Phone
+51 54 452296
Email
informes@4m-expresss.com
Website
busperu4m.com
Bus from Chivay to Cusco
Ave. Duration
9 h 45 min
Frequency
3 times a week
Estimated price
$65
Schedules at
busperu4m.com

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More Questions & Answers

Avianca - Aerovías del Continente Americano S.A. and LATAM Chile offer flights from Santiago Airport to Cuzco Airport.

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There are 1342+ hotels available in Cusco. Prices start at $18 USD per night.

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The best way to get from Santiago to Santiago Airport is to Colectivo which takes 30 min and costs .

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