There are 6 ways to get from Santiago to Bolivia by plane, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly  •  6 h 17 min

  1. Fly from Santiago (SCL) to Santa Cruz (VVI) SCL - VVI

$192 - $693

Cheapest option

Bus Turbus  •  2 days 6 h

  1. Take the bus from Santiago Alameda to Calama Santiago
  2. Take the bus from Calama to Santa Cruz de la Sierra

$66 - $166

4 alternative options

Bus via Teniente Luis Uribe / Sotomayor  •  41 h 48 min

  1. Take the bus from Santiago to Antofagasta
  2. Take the bus from Antofagasta to Santa Cruz

$71 - $126

Bus  •  44 h 2 min

  1. Take the bus from Santiago to Antofagasta Santiago
  2. Take the bus from Antofagasta to Santa Cruz

$87 - $143

Bus Pluss Chile  •  2 days 6 h

  1. Take the bus from Santiago - San Borja to Calama
  2. Take the bus from Calama to Santa Cruz de la Sierra

$87 - $137

Drive  •  31 h 2 min

  1. Drive from Santiago to Santa Cruz de la Sierra 1556.8 miles

$250 - $380

Questions & Answers

The cheapest way to get from Santiago to Bolivia is to bus which costs $70 - $130 and takes 41 h 48 min.

More details

The quickest way to get from Santiago to Bolivia is to fly which costs $190 - $700 and takes 6 h 17 min.

More details

The distance between Santiago and Bolivia is 1909 km. The road distance is 2490.9 km.

Get driving directions

It takes approximately 6 h 17 min to get from Santiago to Bolivia, including transfers.

More details

No, there is no direct bus from Santiago to Bolivia. However, there are services departing from PA448 - Avenida Matta Esq. / San Diego and arriving at Santa Cruz - Ex Terminal via Santiago Alameda, Calama and Santa Cruz Airport - El Trompillo. The journey, including transfers, takes approximately 2 days 6 h.

More details

What companies run services between Santiago, Chile and Bolivia?

LATAM Chile and Aerolíneas Argentinas fly from Santiago to Santa Cruz de la Sierra once daily. Alternatively, you can take a bus from Santiago to Santa Cruz de la Sierra via Antofagasta, Teniente Luis Uribe / Sotomayor, Paihuano / Av. Pedro Aguirre Cerda, Antofagasta, and Santa Cruz in around 41 h 48 min.

Airlines
LATAM Chile
Website
latam.com
Flights from Santiago to Santa Cruz
Ave. Duration
3 h 15 min
When
Tuesday, Thursday and Sunday
Estimated price
$250 - $1,400
Aerolíneas Argentinas
Website
aerolineas.com.ar
Flights from Santiago to Santa Cruz via Buenos Aires Ministro Pistarini
Ave. Duration
6 h 5 min
When
Every day
Estimated price
$270 - $1,100
Bus operators
Trans Salvador
Phone
591-2-5270280
Email
central@trans-salvador.com
Website
trans-salvador.com
Bus from Antofagasta to Santa Cruz
Ave. Duration
25 h
Frequency
Twice daily
Estimated price
$40 - $80
Book at
ticketsbolivia.com.bo
Semi Bed
$40 - $55
Premium
$55 - $70
Bus from Calama to Santa Cruz de la Sierra
Ave. Duration
31 h 30 min
Frequency
3 times a week
Estimated price
$35 - $65
Schedules at
trans-salvador.com
Book at
ticketsbolivia.com.bo
Semi Bed
$35 - $50
Premium
$50 - $60
Expreso Norte
Website
expresonorte.cl
Bus from Santiago to Antofagasta
Ave. Duration
17 h 57 min
Frequency
5 times a day
Estimated price
$45 - $65
Schedules at
expresonorte.cl
Bus from Santiago - San Borja to Calama
Ave. Duration
21 h
Frequency
Twice daily
Estimated price
$50 - $75
Schedules at
expresonorte.cl
Pluss Chile
Phone
+56 (2) 26419926
Email
info@plusschile.cl
Website
plusschile.cl
Bus from Santiago to Antofagasta
Ave. Duration
17 h 46 min
Frequency
3 times a day
Estimated price
$52
Schedules at
plusschile.cl
Book at
altanetpasajes.cl
Bus from Santiago - San Borja to Calama
Ave. Duration
22 h
Frequency
Every 2 hours
Estimated price
$52
Schedules at
plusschile.cl
Book at
altanetpasajes.cl
Buses Evans
Website
busesevans.com
Bus from Santiago - Terminal San Borja to Antofagasta
Ave. Duration
14 h 55 min
Frequency
Once daily
Schedules at
busesevans.com
Turbus
Website
turbus.cl
Bus from Santiago Alameda to Calama
Ave. Duration
20 h 45 min
Frequency
4 times a day
Estimated price
$30 - $100
Schedules at
turbus.cl
2nd Class
$30 - $70
Premium
$70 - $100
1st Class
$90 - $130

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