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There are 7 ways to get from Santiago de Cuba to Cayo Santa María by train, bus, car or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Train, bus  •  14 h 54 min

  1. Take the train from Santiago de Cuba to Santa Clara
  2. Take the bus from Santa Clara to Cayo Santa María Viazul

$32 - $53

6 alternative options

Bus  •  15 h 10 min

  1. Take the bus from Santiago de Cuba to Santa Clara Viazul
  2. Take the bus from Santa Clara to Cayo Santa María Viazul

$40 - $66

Drive  •  9 h 20 min

  1. Drive from Santiago de Cuba to Cayo Santa María 391.4 miles

Fly Santiago to Havana, bus  •  12 h 11 min

  1. Fly from Santiago (SCU) to Havana (HAV) SCU - HAV
  2. Take the bus from La Habana to Santa Clara
  3. Take the bus from Santa Clara to Cayo Santa María

$151 - $372

Fly Santiago to Camaguey, train, bus  •  18 h 12 min

  1. Fly from Santiago (SCU) to Camaguey (CMW) SCU - CMW
  2. Take the train from Camaguey to Cienfuegos
  3. Take the bus from Cienfuegos to Cayo Santa María

$262 - $1,055

Train to Holguin, fly to Havana, bus  •  14 h 24 min

  1. Take the train from Santiago de Cuba to Cacocum
  2. Fly from Holguin (HOG) to Havana (HAV) HOG - HAV
  3. Take the bus from La Habana to Santa Clara
  4. Take the bus from Santa Clara to Cayo Santa María

$146 - $520

Train to Manzanillo, fly to Santa Clara, bus  •  9 h 31 min

  1. Take the train from Santiago de Cuba to Manzanillo
  2. Fly from Manzanillo (MZO) to Santa Clara (SNU) MZO - SNU
  3. Take the bus from Santa Clara to Cayo Santa María

$72 - $242

Questions & Answers

The cheapest way to get from Santiago de Cuba to Cayo Santa María is to train and bus which costs $30 - $55 and takes 14 h 54 min.

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The quickest way to get from Santiago de Cuba to Cayo Santa María is to train and fly and bus which costs $70 - $250 and takes 9 h 31 min.

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No, there is no direct bus from Santiago de Cuba to Cayo Santa María. However, there are services departing from Santiago de Cuba and arriving at Cayo Santa María via Santa Clara. The journey, including transfers, takes approximately 15 h 10 min.

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The distance between Santiago de Cuba and Cayo Santa María is 443 km. The road distance is 626.2 km.

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The best way to get from Santiago de Cuba to Cayo Santa María without a car is to train and bus which takes 14 h 54 min and costs $30 - $55.

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It takes approximately 14 h 54 min to get from Santiago de Cuba to Cayo Santa María, including transfers.

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Santiago de Cuba to Cayo Santa María bus services, operated by Viazul, depart from Santiago de Cuba station.

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The quickest flight from Santiago Airport to Havana Airport is the direct flight which takes 1 h 25 min.

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Santiago de Cuba to Cayo Santa María bus services, operated by Viazul, arrive at Cayo Santa María station.

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Yes, the driving distance between Santiago de Cuba to Cayo Santa María is 626 km. It takes approximately 9 h 20 min to drive from Santiago de Cuba to Cayo Santa María.

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Map of how to get from Santiago de Cuba to Cayo Santa María.
Launch map view
  • Distance: 277 miles
  • Duration: 14 h 54 min

What companies run services between Santiago de Cuba and Cayo Santa María, Sancti Spíritus, Cuba?

You can take a bus from Santiago de Cuba to Cayo Santa María via Santa Clara in around 15 h 10 min.

Airlines
Cubana de Aviación
Website
cubana.cu
Flights from Santiago to Havana
Ave. Duration
1 h 31 min
When
Every day
Estimated price
$130 - $550
Flights from Santiago to Camaguey via Havana
Ave. Duration
8 h 25 min
When
Monday and Friday
Estimated price
$230 - $1,100
Flights from Holguin to Havana
Ave. Duration
1 h 30 min
When
Every day
Estimated price
$110 - $650
Air Caraïbes
Website
aircaraibes.com
Flights from Santiago to Havana
Ave. Duration
1 h 27 min
When
Wednesday and Sunday
Estimated price
$130 - $420
Blue Panorama Airlines
Website
blue-panorama.com
Flights from Santiago to Havana
Ave. Duration
1 h 25 min
When
Monday
Estimated price
$70 - $300
Flights from Holguin to Havana
Ave. Duration
1 h 25 min
When
Saturday
Estimated price
$65 - $290
American Airlines
Website
aa.com
Flights from Santiago to Camaguey via Santo Domingo, Miami
Ave. Duration
7 h 10 min
When
Tuesday
Estimated price
$240 - $1,000
Flights from Santiago to Camaguey via Havana, Miami
Ave. Duration
7 h 55 min
When
Every day
Estimated price
$230 - $1,100
Sunwing Airlines
Website
sunwing.ca
Flights from Manzanillo to Santa Clara
Ave. Duration
1 h
When
Wednesday
Estimated price
$30 - $180
Train operators
Ferrocarriles de Cuba
Website
en.wikipedia.org
Train from Santiago de Cuba to Santa Clara
Ave. Duration
11 h 1 min
Frequency
On demand
Estimated price
$25 - $40
Schedules at
seat61.com
Train from Camaguey to Cienfuegos
Ave. Duration
4 h 14 min
Frequency
On demand
Estimated price
$9 - $14
Schedules at
seat61.com
Train from Santiago de Cuba to Cacocum
Ave. Duration
2 h 34 min
Frequency
On demand
Estimated price
$7 - $11
Schedules at
seat61.com
Train from Santiago de Cuba to Manzanillo
Ave. Duration
3 h 40 min
Frequency
On demand
Estimated price
$11 - $17
Schedules at
seat61.com
Bus operators
Viazul
Phone
+ 53 (07) 8836092
Email
sales@viazul.com
Website
viazul.com
Bus from Santa Clara to Cayo Santa María
Ave. Duration
2 h 25 min
Frequency
Once daily
Estimated price
$7 - $17
Schedules at
viazul.com
Bus from Santiago de Cuba to Santa Clara
Ave. Duration
11 h 45 min
Frequency
Once daily
Estimated price
$30 - $50
Schedules at
viazul.com
Bus from La Habana to Santa Clara
Ave. Duration
3 h 45 min
Frequency
Twice daily
Estimated price
$14 - $21
Schedules at
viazul.com
Book at
viazul.com
Bus from Cienfuegos to Cayo Santa María
Ave. Duration
4 h 10 min
Frequency
Once daily
Estimated price
$10 - $20
Schedules at
viazul.com

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More Questions & Answers

Air Caraïbes, Blue Panorama Airlines and Cubana de Aviación offer flights from Santiago Airport to Havana Airport.

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There are two+ hotels available in Cayo Santa María. Prices start at $100 USD per night.

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The best way to get from Santiago de Cuba to Santiago Airport is to line 212 bus which takes 24 min and costs .

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